In this issue (22 articles)

1. Commentary

   Lipotoxicity impairs incretin signalling

   V. Poitout Pages 231-233

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2. Review

   Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

   D. L. Eizirik, M. Miani, A. K. Cardozo Pages 234-241

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3. Systematic Review

   Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis

   D. Umpierre, P. A. B. Ribeiro, B. D. Schaan, J. P. Ribeiro Pages 242-251

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4. Article

   Worse glycaemic control in LADA patients than in those with type 2 diabetes, despite a longer time on insulin therapy

   C. D. Andersen, L. Bennet, L. Nyström, U. Lindblad, E. Lindholm, L. Groop… Pages 252-258

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5. 

   Article

   A urinary peptide biomarker set predicts worsening of albuminuria in type 2 diabetes mellitus

   S. S. Roscioni, D. de Zeeuw, M. E. Hellemons, H. Mischak, P. Zürbig… Pages 259-267

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6. 

   Article

   Associations between longevity of parents and glucose regulation in their offspring: the KORA S4/F4 Study

   B. Kowall, A. Peters, B. Thorand, W. Rathmann, C. Meisinger Pages 268-274

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7. 

   Article

   Prediction and classification of cardiovascular disease risk in older adults with diabetes

   K. J. Mukamal, J. R. Kizer, L. Djoussé, J. H. Ix, S. Zieman… Pages 275-283

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8. Article

   Improved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomised Finnish Diabetes Prevention Study (DPS)

   J. Lindström, M. Peltonen, J. G. Eriksson, P. Ilanne-Parikka, S. Aunola… Pages 284-293

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9. 

   Short Communication

   Effect of time of day and fasting duration on measures of glycaemia: analysis from the Whitehall II Study

   A. Hulmán, K. Færch, D. Vistisen, J. Karsai, T. A. Nyári, A. G. Tabák… Pages 294-297

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10. Article

    Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

    A. Albrechtsen, N. Grarup, Y. Li, T. Sparsø, G. Tian, H. Cao, T. Jiang… Pages 298-310

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11. 

    Article

    Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology

    F. Bernhard, K. Landgraf, N. Klöting, A. Berthold, P. Büttner, D. Friebe… Pages 311-322

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12. 

    Article

    Common variant in the HMGA2 gene increases susceptibility to nephropathy in patients with type 2 diabetes

    S. Alkayyali, M. Lajer, H. Deshmukh, E. Ahlqvist, H. Colhoun, B. Isomaa… Pages 323-329

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13. Article

    Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouse

    S. Zertal-Zidani, K. Busiah, A. Edelman, M. Polak, R. Scharfmann Pages 330-339

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14. 

    Article

    The human L-type calcium channel Ca_v1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes

    T. M. Reinbothe, S. Alkayyali, E. Ahlqvist, T. Tuomi, B. Isomaa… Pages 340-349

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15. Article

    Adaptive changes of human islets to an obesogenic environment in the mouse

    S. Gargani, J. Thévenet, J. E. Yuan, B. Lefebvre, N. Delalleau, V. Gmyr… Pages 350-358

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16. 

    Article

    Syntaxin-3 regulates newcomer insulin granule exocytosis and compound fusion in pancreatic beta cells

    D. Zhu, E. Koo, E. Kwan, Y. Kang, S. Park, H. Xie, S. Sugita, H. Y. Gaisano Pages 359-369

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17. Article

    Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes

    S. Liu, G. Kilic, M. S. Meyers, G. Navarro, Y. Wang, J. Oberholzer… Pages 370-381

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18. 

    Article

    Human blood outgrowth endothelial cells improve islet survival and function when co-transplanted in a mouse model of diabetes

    V. Coppens, Y. Heremans, G. Leuckx, K. Suenens… Pages 382-390

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19. Article

    Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial

    K. C. Herold, S. E. Gitelman, S. M. Willi, P. A. Gottlieb, F. Waldron-Lynch… Pages 391-400

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20. 

    Article

    Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes

    W. Zheng, X. Feng, L. Qiu, Z. Pan, R. Wang, S. Lin, D. Hou, L. Jin, Y. Li Pages 401-411

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