Volume 14, Issue 4, December 2012

ISSN: (Print) 1550-7416 (Online)

In this issue (30 articles)

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  1. No Access

    Research Article

    Evaluation of an Innovative Population Pharmacokinetic-Based Design for Behavioral Pharmacodynamic Endpoints

    Anders Viberg, Giovanni Martino, Etienne Lessard, Jennifer M. A. Laird Pages 657-663
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  2. No Access

    Regulatory Note

    Statistics on BCS Classification of Generic Drug Products Approved Between 2000 and 2011 in the USA

    Anil K. Nair, Om Anand, Nam Chun, Dale P. Conner, Mehul U. Mehta… Pages 664-666
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    Research Article

    Effect of Device Design on the In Vitro Performance and Comparability for Capsule-Based Dry Powder Inhalers

    Jagdeep Shur, Sau Lee, Wallace Adams, Robert Lionberger, James Tibbatts… Pages 667-676
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    Review Article

    Crystalline Nanosuspensions as Potential Toxicology and Clinical Oral Formulations for BCS II/IV Compounds

    Filippos Kesisoglou, Amitava Mitra Pages 677-687
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    Review Article

    Engineered Nanoparticulate Drug Delivery Systems: The Next Frontier for Oral Administration?

    Roudayna Diab, Chiraz Jaafar-Maalej, Hatem Fessi, Philippe Maincent Pages 688-702
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    Review Article

    Characterization of Supersaturatable Formulations for Improved Absorption of Poorly Soluble Drugs

    Ping Gao, Yi Shi Pages 703-713
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    Review Article

    Absorption, Distribution, Metabolism, and Excretion (ADME) Studies of Biotherapeutics for Autoimmune and Inflammatory Conditions

    Yulia Vugmeyster, John Harrold, Xin Xu Pages 714-727
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  8. Research Article

    Phosphorothioate Oligonucleotide Quantification by μ-Liquid Chromatography-Mass Spectrometry

    Robert Erb, Katharina Leithner, Andreas Bernkop-Schnürch… Pages 728-737
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    Review Article

    Bioequivalence Requirements in the European Union: Critical Discussion

    Alfredo García-Arieta, John Gordon Pages 738-748
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    Review Article

    Guidelines for the Quality Control of Population Pharmacokinetic–Pharmacodynamic Analyses: an Industry Perspective

    P. L. Bonate, A. Strougo, A. Desai, M. Roy, A. Yassen… Pages 749-758
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    Commentary

    Drug Repurposing: Far Beyond New Targets for Old Drugs

    T. I. Oprea, J. Mestres Pages 759-763
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    Research Article

    Rationalizing Structure and Target Relationships between Current Drugs

    Ye Hu, Jürgen Bajorath Pages 764-771
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  13. No Access

    Research Article

    A One-Step Solid Phase Extraction Method for Bioanalysis of a Phosphorothioate Oligonucleotide and Its 3′ n-1 Metabolite from Rat Plasma by uHPLC–MS/MS

    Buyun Chen, Michael Bartlett Pages 772-780
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    Review Article

    Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics

    Xin Xu, Yulia Vugmeyster Pages 781-791
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    Review Article

    International Veterinary Bioequivalence Guideline Similarities and Differences Between Australia, Canada, Europe, Japan, New Zealand and the United States

    Chantal Lainesse Pages 792-798
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    Review Article

    ADME of Antibody–Maytansinoid Conjugates

    Hans K. Erickson, John M. Lambert Pages 799-805
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    Research Article

    Variation of Stratum Corneum Biophysical and Molecular Properties with Anatomic Site

    Diar Mohammed, Paul J. Matts, Jonathan Hadgraft, Majella E. Lane Pages 806-812
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  18. Review Article

    Metrics for the Evaluation of Bioequivalence of Modified-Release Formulations

    Laszlo Endrenyi, Laszlo Tothfalusi Pages 813-819
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    Review Article

    Monoamine Transporter Structure, Function, Dynamics, and Drug Discovery: A Computational Perspective

    Sankar Manepalli, Christopher K. Surratt, Jeffry D. Madura… Pages 820-831
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  20. No Access

    Research Article

    Functional and Molecular Aspects of Biotin Uptake via SMVT in Human Corneal Epithelial (HCEC) and Retinal Pigment Epithelial (D407) Cells

    Aswani Dutt Vadlapudi, Ramya Krishna Vadlapatla, Dhananjay Pal… Pages 832-842
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