1. Pharmacodynamic Modeling of Sequence-Dependent Antitumor Activity of Insulin-like Growth Factor Blockade and Gemcitabine

   • Amit Khatri
   • Richard C. Brundage
   • Mark N. Kirstein

   Research Article 19 November 2011 Pages: 1 - 9

   

2. Absorption Enhancers: Applications and Advances

   • Bruce J. Aungst

   Review Article 22 November 2011 Pages: 10 - 18

3. Common Deficiencies with Bioequivalence Submissions in Abbreviated New Drug Applications Assessed by FDA

   • Qing Liu
   • Barbara M. Davit
   • Dale P. Conner

   Regulatory Note 01 December 2011 Pages: 19 - 22

   

4. Comparison of Intestinal Absorption and Disposition of Structurally Similar Bioactive Flavones in Radix Scutellariae

   • Chenrui Li
   • Li Zhang
   • Zhong Zuo

   Research Article 14 December 2011 Pages: 23 - 34

   

5. PEGylation of a Factor VIII–Phosphatidylinositol Complex: Pharmacokinetics and Immunogenicity in Hemophilia A Mice

   • Aaron Peng
   • Matthew P. Kosloski
   • Sathy V. Balu-Iyer

   Research Article 16 December 2011 Pages: 35 - 42

   

6. Synthesis and Pharmacological Characterization of a Novel Sigma Receptor Ligand with Improved Metabolic Stability and Antagonistic Effects Against Methamphetamine

   • Michael J. Seminerio
   • Matthew J. Robson
   • Rae R. Matsumoto

   Research Article 20 December 2011 Pages: 43 - 51

   

7. The Risk of Recurrence in Breast Cancer Patients Treated with Tamoxifen: Polymorphisms of CYP2D6 and ABCB1

   • L. K. Teh
   • N. I. Mohamed
   • J. Din

   Research Article 20 December 2011 Pages: 52 - 59

   

8. On Average: Data Exploration Based on Means Can Be Misleading

   • Adrian Dunne
   • Mila Etropolski
   • Partha Nandy

   Commentary 22 December 2011 Pages: 60 - 67

   

9. Effect of Cyclosporine and Rifampin on the Pharmacokinetics of Macitentan, a Tissue-Targeting Dual Endothelin Receptor Antagonist

   • Shirin Bruderer
   • Päivi Äänismaa
   • Jasper Dingemanse

   Research Article Open access 22 December 2011 Pages: 68 - 78

   

10. Modification of Disodium Cromoglycate Passage Across Lung Epithelium In Vitro Via Incorporation into Polymeric Microparticles

    • Mehra Haghi
    • Rania Salama
    • Paul M. Young

    Research Article 28 December 2011 Pages: 79 - 86

    

11. Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate

    • Stina Syvänen
    • Maarten Schenke
    • Elizabeth C. de Lange

    Research Article Open access 04 January 2012 Pages: 87 - 96

    

12. Disposition of Human Recombinant Lubricin in Naive Rats and in a Rat Model of Post-traumatic Arthritis After Intra-articular or Intravenous Administration

    • Yulia Vugmeyster
    • Qin Wang
    • Moisés A. Rivera-Bermúdez

    Research Article 07 January 2012 Pages: 97 - 104

    

13. Ligand-Binding Assays in the 21st Century Laboratory: Recommendations for an Automated Data Interchange Process

    • Sheldon S. Leung
    • Joel Usansky
    • David Rusnak

    Commentary 14 January 2012 Pages: 105 - 112

    

14. Ligand Binding Assays in the 21st Century Laboratory: Platforms

    • Franklin P. Spriggs
    • Zhandong Don Zhong
    • Chad Ray

    Commentary 19 January 2012 Pages: 113 - 118

15. Covariate Pharmacokinetic Model Building in Oncology and its Potential Clinical Relevance

    • Markus Joerger

    Review Article 25 January 2012 Pages: 119 - 132

16. Structure-Based Virtual Screening for Drug Discovery: a Problem-Centric Review

    • Tiejun Cheng
    • Qingliang Li
    • Stephen H. Bryant

    Review Article Open access 27 January 2012 Pages: 133 - 141

    

17. Ligand Binding Assays in the 21st Century Laboratory: Automation

    • Ago B. Ahene
    • Chris Morrow
    • John Derent

    Commentary 01 February 2012 Pages: 142 - 153