1. Letter from the guest editors

   • Peter S. McPherson
   • Hanna M. Pappius

   EditorialNotes Pages: 1 - 1

2. An appreciation

   • Hanna M. Pappius

   Announcement Pages: 3 - 4

3. Building a cathedral

   • Matthew W. Spence

   OriginalPaper Pages: 5 - 13

4. Design and serendipity in the path to prostaglandins

   • Flavio Coceani

   OriginalPaper Pages: 15 - 18

5. Novel eicosanoid pathways

   • Cecil R. Pace-Asciak

   OriginalPaper Pages: 19 - 26

6. Lysosomal membrane proteomics and biogenesis of lysosomes

   • Richard D. Bagshaw
   • Don J. Mahuran
   • John W. Callahan

   OriginalPaper Pages: 27 - 41

7. Enzyme replacement therapy of fabry disease

   • Joe T. R. Clarke
   • R. Mark Iwanochko

   OriginalPaper Pages: 43 - 50

8. Cortical spreading depression modifies components of the inflammatory cascade

   • Charlie S. Thompson
   • Antoine M. Hakim

   OriginalPaper Pages: 51 - 57

9. How astrocytes feed hungry neurons

   • Luc Pellerin

   OriginalPaper Pages: 59 - 72

10. Peptide motifs

    • Peter S. McPherson
    • Brigitte Ritter

    OriginalPaper Pages: 73 - 87

11. Lipid signaling in neural plasticity, brain repair, and neuroprotection

    • Nicolas G. Bazan

    OriginalPaper Pages: 89 - 103