1. Thoughts on current guidelines for managing patients with acute coronary syndromes

   • Joseph S. Alpert

   Editor’s Commentary Pages: 81 - 84

2. Recent clinical trials in valvular heart diseases

   • Maurice Enriquez-Sarano

   Invited Commentary Pages: 85 - 87

3. Web alert

   News Pages: 88 - 90

4. Literature alert

   Abstract Pages: 91 - 94

5. The renin-angiotensin system in mitral regurgitation: A typical example of tissue activation

   • Louis J. Dell'Italia

   OriginalPaper Pages: 97 - 103

6. The long-term outcome of mitral valve repair for mitral valve prolapse

   • Dania Mohty
   • Maurice Enriquez-Sarano

   OriginalPaper Pages: 104 - 110

7. Aortic valve sclerosis as a marker of active atherosclerosis

   • Kelley R. Branch
   • Kevin D. O’Brien
   • Catherine M. Otto

   OriginalPaper Pages: 111 - 117

8. The long-term outcome of balloon valvuloplasty for mitral stenosis

   • Bernard Iung
   • Alec Vahanian

   OriginalPaper Pages: 118 - 124

9. Mechanistic insights into functional mitral regurgitation

   • Robert A. Levine
   • Judy Hung
   • Gus J. Vlahakes

   OriginalPaper Pages: 125 - 129

10. Clinical trials report

    • Jesse Weinberger

    BriefCommunication Pages: 133 - 134

11. Innovative strategies in the management of acute stroke

    • Lawrence R. Wechsler

    OriginalPaper Pages: 135 - 140

12. Mechanisms of cardioembolic stroke

    • Marco R. Di Tullio
    • Shunichi Homma

    OriginalPaper Pages: 141 - 148

13. Evaluation and management of acute ischemic stroke

    • Birgitte H. Bendixen
    • Lenore Ocava

    OriginalPaper Pages: 149 - 157

14. Management of hemorrhagic stroke

    • Stanley Tuhrim

    OriginalPaper Pages: 158 - 163

15. Prevention of ischemic stroke

    • Jesse Weinberger

    OriginalPaper Pages: 164 - 171