1. A Pharmacokinetic/Pharmacodynamic Approach to Predict the Cumulative Cortisol Suppression of Inhaled Corticosteroids

   • Bernd Meibohm
   • Günther Hochhaus
   • Hartmut Derendorf

   OriginalPaper 01 April 1999 Pages: 127 - 147

2. Mixed Effect Modeling of Sumatriptan Pharmacokinetics During Drug Development: II. From Healthy Subjects to Phase 2 Dose Ranging in Patients

   • Valérie F. Cosson
   • Eliane Fuseau

   OriginalPaper 01 April 1999 Pages: 149 - 171

3. Do Plasma Concentrations Obtained from Early Arterial Blood Sampling Improve Pharmacokinetic/Pharmacodynamic Modeling?

   • Ton M. Beaufort
   • Johannes H. Proost
   • J. Mark K. H. Wierda

   OriginalPaper 01 April 1999 Pages: 173 - 190

4. Construction of an Optimal Destructive Sampling Design for Noncompartmental AUC Estimation

   • Francois Vandenhende
   • Muriel Comblain
   • Bruno Boulanger

   OriginalPaper 01 April 1999 Pages: 191 - 212

5. Constructing a Prediction Interval for Time to Reach a Threshold Concentration Based on a Population Pharmacokinetic Analysis: An Application to Basiliximab in Renal Transplantation

   • France Mentré
   • John Kovarik
   • Christophe Gerbeau

   OriginalPaper 01 April 1999 Pages: 213 - 230

6. Announcements

   Announcement 01 April 1999 Pages: 231 - 232