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Meiotic segregation of chromosomes 13 and 14 in sperm of heterozygous Robertsonian translocation der(13;14)(q10;q10) carriers

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Abstract

Meiotic segregation of chromosomes 13 and 14 was assessed by fluorescence in situ hybridization on sperm of five heterozygous carriers of the most frequent Robertsonian translocation der(13;14). Alternate segregation mode was predominant (mean 78.2 ± 5.7%). The prevalence of balanced sperm varied from 69.4 to 86.5%. Adjacent segregation mode was detected in 18.64 ± 4.90% of sperm; 3:0 mode was detected in 2.48 ± 1.20% of sperm. These results are informative for reproductive counseling of Robertsonian translocation der(13;14) carriers providing information for assessment of probability of receiving normal/balanced embryos in assisted reproduction cycles.

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Authors and Affiliations

  1. Center of Molecular and Cell Research, National University of Kyiv-Mohyla Academy, ul. Grigoriya Skovorody 2, Kyiv, 04655, Ukraine

    L. Y. Pylyp & N. M. Bilko

  2. Clinic of Reproductive Medicine “Nadiya”, ul. Maksima Krivonosa 19, Kyiv, 01025, Ukraine

    L. A. Spinenko & V. D. Zukin

Authors
  1. L. Y. Pylyp
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  2. L. A. Spinenko
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  3. V. D. Zukin
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  4. N. M. Bilko
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Correspondence to L. Y. Pylyp.

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Original Russian Text © L.Y. Pylyp, L.A. Spinenko, V.D. Zukin, N.M. Bilko, 2014, published in Tsitologiya i Genetika, 2014, Vol. 48, No. 3, pp. 48–53.

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Pylyp, L.Y., Spinenko, L.A., Zukin, V.D. et al. Meiotic segregation of chromosomes 13 and 14 in sperm of heterozygous Robertsonian translocation der(13;14)(q10;q10) carriers. Cytol. Genet. 48, 175–179 (2014). https://doi.org/10.3103/S0095452714030086

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  • DOI: https://doi.org/10.3103/S0095452714030086

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