Abstract
The results of conducted research studies suggest that heredity and early fetal and neonatal development play a causal role in autism. The objective was to determine a relationship between pre-, peri-, and neonatal factors and autism. The relationship between genders and individual risk factors for autism was also examined. A case-control study was conducted among 288 children (96 cases with childhood or atypical autism and 192 controls individually matched to cases by the year of birth, sex, and general practitioners). Data on autism diagnosis and other medical conditions were acquired from physicians. All other information on potential autism risk factors were collected from mothers. Autism risk was significantly higher when mothers were taking medications (OR=2.72, 95%CI: 1.47-5.04) and smoked during pregnancy (OR=3.32, 95%CI: 1.12-9.82). It was also significantly associated with neonatal dyspnea (OR=3.20, 95%CI: 1.29-8.01) and congenital anomalies (OR=7.17, 95%CI: 2.23-23.1). In gender analysis only congenital anomalies were significantly associated with autism for girls but all of mentioned factors stayed independent risk factors for boys.
Similar content being viewed by others
References
Lauritsen M., Ewald H., The genetics of autism, Acta Psychiat. Scand., 2001, 103(6), 411–427
Gupta A.R., State M.W., Recent advances in the genetics of autism, Biol. Psychiat., 2007, 61(4), 429–437
Bailey A., Le Couteur A., Gottesman I., Bolton P., Simonoff E., Yuzda E., et al., Autism as a strongly genetic disorder, evidence from a British twin study, Psychol. Med., 1995, 25(1), 63–77
Bilder D., Pinborough-Zimmerman J., Miller J., McMahon W., Prenatal perinatal and neonatal factors associated with autism spectrum disorders, Pediatrics, 2009, 123(5), 1293–1300
Buchmayer S., Johansson S., Johansson A., Hultman C.M., Sparén P., Cnattingius S., Can association between preterm birth and autism be explained by maternal or neonatal morbidity?, Pediatrics, 2009, 124(5), e817–825
Juul-Dam N., Townsend J., Courchesne E., Prenatal perinatal and neonatal factors in autism pervasive developmental disorder-not otherwise specified and the general population, Pediatrics, 2001, 107(4), e63
Reichenberg A., Gross R., Weiser M., Bresnahan M., Silverman J., Harlap S., et al., Advancing paternal age and autism, Arch. Gen. Psychiat., 2006, 63(9), 1026–1032
Shelton J.F., Tancredi D.J., Hertz-Picciotto I., Independent and dependent contributions of advanced maternal and paternal ages to autism risk, Autism Res., 2010, 3(1), 30–39
Mrozek-Budzyn D., Kiełtyka A., Majewska R., Lack of association between measles-mumps-rubella vaccination and autism in children, a case-control study, Pediatr. Infect. Dis. J., 2010, 29(5), 397–400
Fombonne E., The prevalence of autism, JAMA, 2003, 289(1), 87–89
Hultman C.M., Sparén P., Cnattingius S., Perinatal risk factors for infantile autism, Epidemiology, 2002, 13(4), 417–423
Maimburg R.D., Vaeth M,, Perinatal risk factors and infantile autism, Acta Psychiatr. Scand., 2006, 114(4), 257–264
Ozgen H., Hellemann G.S., Stellato R.K., Lahuis B., van Daalen E., Staal W.G., et al., Morphological Features in Children with Autism Spectrum Disorders, A Matched Case-Control Study, J. Autism Dev. Disord., 2011, 41(1), 23–31
Dawson S., Glasson E.J., Dixon G., Bower C., Birth defects in children with autism spectrum disorders, a population-based nested case-control study, Am. J. Epidemiol., 2009, 169(11), 1296–1303
Ploeger A., Raijmakers M.E., van der Maas H.L., Galis F., The association between autism and errors in early embryogenesis, what is the causal mechanism?, Biol. Psychiat. 2010, 67(7), 602–607
Lauritsen M.B., Mors O., Mortensen P.B., Ewald H., Medical disorders among inpatients with autism in Denmark according to ICD-8, a nationwide register-based study, J. Autism Dev. Disord., 2002, 32(2), 115–119
Wier M.L., Yoshida C.K., Odouli R., Grether J.K., Croen L.A., Congenital anomalies associated with autism spectrum disorders, Dev. Med. Child Neurol., 2006, 48(6), 500–507
Libbey J.E., Sweeten T.L., McMahon W.M., Fujinami R.S., Autistic disorder and viral infections, J. Neurovirol., 2005, 11(1) 1–10
Ponzio N.M., Servatius R., Beck K., Marzouk A., Kreider T., Cytokine levels during pregnancy influence immunological profiles and neurobehavioral patterns of the offspring, Ann. NY Acad. Sci., 2007, 1107, 118–128
Brown A.S., Begg M.D., Gravenstein S., Schaefer C.A., Wyatt R.J., Bresnahan M., et al., Serologic evidence of prenatal influenza in the etiology of schizophrenia, Arch. Gen. Psychiat., 2004, 61(8), 774–780
Sorensen H.J., Mortensen E.L., Reinisch J.M., Mednick S.A., Association between prenatal exposure to bacterial infection and risk of schizophrenia, Schizophrenia Bull., 2009, 35(3), 631–637
Ashdown H., Dumont Y., Ng M., Poole S., Boksa P., Luheshi G.N., The role of cytokines in mediating effects of prenatal infection on the fetus, implications for schizophrenia, Mol. Psychiatr., 2006, 11(1), 47–55
Nahmias A.J., Nahmias S.B., Danielsson D., The possible role of transplacentally-acquired antibodies to infectious agents with molecular mimicry to nervous system sialic acid epitopes as causes of neuromental disorders, prevention and vaccine implications, Clin. Dev. Immunol., 2006, 13(2-4), 167–183
Atladóttir H.O., Thorsen P., Schendel D.E., Ostergaard L., Lemcke S., Parner E.T., Association of hospitalization for infection in childhood with diagnosis of autism spectrum disorders, a Danish cohort study, Arch. Pediatr. Adolesc. Med., 2010, 164(5), 470–7
Meyer U., Yee B.K., Feldon J., The neurodevelopmental impact of prenatal infections at different times of pregnancy, the earlier the worse?, Neuroscientist, 2007, 13(3), 241–256
Cannell J.J., Autism and vitamin D, Med. Hypotheses, 2008, 70(4), 750–759
Valko M., Morris H., Cronin M.T., Metals toxicity and oxidative stress, Curr. Med. Chem., 2005, 12(10), 1161–1208
Coen N., Mothersill C., Kadhim M., Wright E.G., Heavy metals of relevance to human health induce genomic instability, The J. Pathol., 2001, 195(3), 293–299
Fergusson D.M., Horwood L.J., Lynskey M.T., Maternal smoking before and after pregnancy, effects on behavioral outcomes in middle childhood, Pediatrics, 1993, 92(6), 815–822
Sebat J., Lakshmi B., Malhotra D., Troge J., Lese-Martin C., Walsh T., et al., Strong association of de novo copy number mutations with autism, Science, 2007, 316(5823), 445–449
Glasson E.J., Bower C., Petterson B., de Klerk N., Chaney G., Hallmayer J.F., Perinatal factors and the development of autism, a population study, Arch. Gen. Psychiat., 2004, 61(6) 618–627
Engels H., Brockschmidt A., Hoischen A., Landwehr C., Bosse K., Walldorf C., et al., DNA microarray analysis identifies candidate regions and genes in unexplained mental retardation, Neurology, 2007, 68(10) 743–750
Larsson H.J., Eaton W.W., Madsen K.M., Vestergaard M., Olesen A.V., Agerbo E., et al., Risk factors for autism, perinatal factors parental psychiatric history and socioeconomic status, Am. J. Epidemiol., 2005, 161(10), 916–925
Rice D., Barone S. Jr., Critical periods of vulnerability for the developing nervous system, evidence from humans and animal models, Environ. Health. Persp., 2000, 108(3), 511–533
Guillem P., Cans C., Guinchat V., Ratel M., Jouk P.S., Trends perinatal characteristics and medical conditions in pervasive developmental disorders, Dev. Med. Child Neurol., 2006, 48(11), 896–900
Baron-Cohen S., Knickmeyer R.C., Belmonte M.K., Sex differences in the brain, implications for explaining autism, Science, 2005, 310(5749), 819–823
Miller M.T., Strömland K., Ventura L., Johansson M., Bandim J.M., Gillberg C., Autism associated with conditions characterized by developmental errors in early embryogenesis, a mini review, Int. J. Dev. Neurosci., 2005, 23(2-3), 201–219
Rodier P.M., Converging evidence for brain stem injury in autism, Dev. Psychopathol., 2002, 14(3), 537–557
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Mrozek-Budzyn, D., Majewska, R. & Kieltyka, A. Prenatal, perinatal and neonatal risk factors for autism - study in Poland. cent.eur.j.med 8, 424–430 (2013). https://doi.org/10.2478/s11536-013-0174-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.2478/s11536-013-0174-5