Skip to main content
SpringerLink
Log in

Association between Helicobacter. pylori and coronary artery disease

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

The high prevalence of both Helicobacter.pylori infection and coronary atherosclerosis in our country prompted us to assess the probable association between both conditions. This cross-sectional study recruited 153 patients scheduled to undergo coronary artery angiography. Patients were divided into two groups on the basis of coronary angiography results. Sixty-nine patients had coronary atherosclerosis and the 84 remaining patients were normal. Characteristics and pre-angiographic serum levels of triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein, and Helicobacter.pylori IgG antibody were assessed in the patients and compared between the groups. Helicobacter.pylori infection occurred in 88 (57.51%) patients: 40 (58%) in the atherosclerotic group and 48 (57.1%) in the control group with no significant differences (P=0.918). Our multivariable analysis revealed that Helicobacter.pylori infection was not an independent predictive factor for coronary artery disease (P =0.915). Also, the prevalence of atherosclerosis risk factors with respect to the seropositive and seronegative Helicobacter.pylori infection was assessed in the case group, which showed no significant difference. Furthermore, the prevalence of seropositive Helicobacter.pylori infection in terms of the number of diseased coronary vessels was evaluated, this demonstrated no significant association between the number of the diseased vessels and Helicobacter.pylori infection. This study demonstrated that Helicobacter.pylori infection was not an independent predictive factor of atherosclerosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Tabatabaei Yazdi SA, Rezaei A, Bordbar Azari J, Hejazi A, Shakeri MT, Karimi Shahri M. Prevalence of Atherosclerotic Plaques in Autopsy Cases with Noncardiac Death. Iranian Journal of Pathology 2009; 4: 101–104

    Google Scholar 

  2. Kadar A, Glasz T. Development of atherosclerosis and plaque biology. Cardiovasc Surg 2001; 9:109–21

    Article  CAS  PubMed  Google Scholar 

  3. Pasceri V, Cammarota G, Patti G, Cuoco L, Gasbarrini A, Grillo RL, Fedeli G, Gasbarrini G, Maseri A. Association of virulent Helicobacter pylori strains with ischaemic heart disease. Circulation 1998; 97:1675–9

    CAS  PubMed  Google Scholar 

  4. Ridker PM, Danesh J, Youngman L, Collins R, Stampfer MJ, Peto R, Hennekens CH. A prospective study of Helicobacter pylori seropositivity and the risk for future myocardial infarction among socioeconomically similar U.S. men. Ann Intern Med 2001; 135:184–8

    CAS  PubMed  Google Scholar 

  5. Stone AF, Risley P, Markus HS, Butland BK, Strachan DP, Elwood PC, Mendall MA. Ischaemic heart disease and Cag A strains of Helicobacter pylori in the Caerphilly heart disease study. Heart 2001; 86: 506–9

    Article  CAS  PubMed  Google Scholar 

  6. Patel P, Mendall MA, Carrington D, Strachan DP, Leatham E, Molineaux N, J Levy, C Blakeston, C A Seymour, A J Camm, T C Northfield. Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. BMJ 1995; 311: 711–714

    CAS  PubMed  Google Scholar 

  7. Murray LJ, Bamford KB, Kee F, McMaster D, Cambien F, Dallongeville J, Evans A. Infection with virulent strains of Helicobacter pylori is not associated with ischaemic heart disease: evidence from a populationbased case-control study of myocardial infarction. Atherosclerosis 2000; 149:379–85

    Article  CAS  PubMed  Google Scholar 

  8. Zhu J, Quyyumi AA, Muhlestein JB, Nieto FJ, Horne BD, Zalles-Ganley A, Anderson JL, Epstein SE. Lack of association of Helicobacter pylori infection with coronary artery disease and frequency of acute myocardial infarction or death. Am J Cardiol 2002; 89:155–8

    Article  CAS  PubMed  Google Scholar 

  9. Bazzazi H, Ramezani M.A, Bazoori M, Mohamadi Bondarkheili A, ArabAhmadi M, Ghaemi E. Seroepidemiology of Helicobacter Pylori infection in Patients with coronary syndrome in Gorgan. Medical Laboratory Journal 2007; 1: 33–37

    Google Scholar 

  10. Dunn BE, Cohen H, Blaser MJ. Helicobacter pylori. Clin Microbiol Rev 1997; 10:720–41

    CAS  PubMed  Google Scholar 

  11. Thoreson AC, Borre M, Andersen LP, Jorgensen F, Kiilerich S, Scheibel J, Rath J, Krogfelt KA.. Helicobacter pylori detection in human biopsies: a competitive PCR assay with internal control reveals false results. FEMS Immunol Med Microbiol 1999; 24: 201–8

    Article  CAS  PubMed  Google Scholar 

  12. Arias E, Martinetto H, Schultz M, Ameriso S, Rivera S, Lossetti O, Sevlever G. Seminested Polymerase Chain Reaction (PCR) for Detecting Helicobacter pylori DNA in Carotid Atheromas. Diagn Mol Pathol 2006; 15:174–179

    Article  CAS  PubMed  Google Scholar 

  13. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002; 347: 1175–86

    Article  CAS  PubMed  Google Scholar 

  14. Rahnama B, Zadegan N, Fatahi E, Samadi Khah J. Survey On The Association Of Seropositivity Of H.Pylori IgG With Acute Myocardial Infarction. Journal of Kerman University of Medical Sciences 2001; 8: 66–73 [abstract in English]

    Google Scholar 

  15. Aghajani CM, Abbasian M. Association of Helicobacter pylori infection and its Cag A-positive strains with coronary heart disease. Journal of Tebe Jonob 2002; 1: 62–65 [abstract in English]

    Google Scholar 

  16. Folsom AR, Nieto FJ, Sorlie P, Chambless LE, Graham DY. Helicobacter pylori seropositivity and coronary heart disease incidence: Atherosclerosis Risk In Communities (ARIC) Study Investigators. Circulation 1998; 98: 845–850

    CAS  PubMed  Google Scholar 

  17. Stollberger C, Molzer G, Finsterer J. Seroprevalence of antibodies to microorganisms known to cause arterial and myocardial damage in patients with or without coronary stenosis. Clin Diagn Lab Immunol 2001; 8: 997–1002

    CAS  PubMed  Google Scholar 

  18. Tasi CJ, Huang TY. Relation of Helicobacter pylori infection and angiographically demonstrated coronary artery disease. Dig Dis Sci 2000; 45:1227–32

    Article  Google Scholar 

  19. Carlsson J, Miketic S, Brom J, Ross R, Bachmann H, Tebbe U. Prior cytomegalovirus, Chlamydia pneumoniae or Helicobacter pylori infection and the risk of restenosis after percutaneous transluminal coronary angioplasty. Int J Cardiol 2000; 73:165–71

    Article  CAS  PubMed  Google Scholar 

  20. Biagi P, Fabbrini D, Bocchini S. Seroprevalence of Helicobacter pylori infection in a group of hospitalized geriatric patients. Panminerva Med 2000; 42:183–6[Abs]

    CAS  PubMed  Google Scholar 

  21. Danesh J, Wong Y, Ward M, Muir J. Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease. Heart 1999; 81:245–7

    CAS  PubMed  Google Scholar 

  22. Mendall MA, Goggin PM, Molineaux N, Levy J, Toosy T, Strachan D, Camm AJ, Northfield TC. Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J 1994; 71:43–79

    Article  Google Scholar 

  23. Alkout AM, Ramsay EJ, Mackenzie DA, Weir DM, Bentley AJ, Elton RA, Sutherland S, Busuttil A, Blackwell CC. Quantitative assessment of IgG antibodies of Helicobacter pylori and outcome of ischaemic heart disease. FEMS Immunol Med Microbiol 2002; 29:271–4

    Article  Google Scholar 

  24. Pellicano R, Mazzarello MG, Morelloni S, Allegri M, Arena V, Ferrari M, Rizzetto M, Ponzetto A. Acute myocardial infarction and Helicobacter pylori seropositivity. Int J Clin Lab Res 1999; 29:141–4

    Article  CAS  PubMed  Google Scholar 

  25. Danesh J, Youngman L, Clark S, Parish S, Peto R, Collins R. Helicobacter pylori infection and early onset myocardial infarction: case-control and sibling pairs study. Br Med J 1999; 319:1157–62

    CAS  Google Scholar 

  26. Pieniazek P, Karczewska E, Duda A, Tracz W, Pasowicz M, Konturek SJ. Association of Helicobacter pylori infection with coronary heart disease. J Physiol Pharmacol 1999; 50:743–51

    CAS  PubMed  Google Scholar 

  27. Kanbay M, Gur G, Yucel M, Muderrisoglu H. Helicobacter pylori sero prevalence in patients with coronary artery disease. Digestive Diseases and Sciences 2005 Nov;50(11):2071–2074

    Article  PubMed  Google Scholar 

  28. Kowalski M, Kunturek PC, Karczewska E, Karczewska E, Kluczka A, Grove R, Kranig W, Nasseri R, Thale J, Hahn EG, Konturek SJ. Prevalence of helicobacter pylori infection in coronary artery disease and effect of its eradication on coronary lumen reduction after perecutaneous coronary angioplasty. Digest Liver Dis 2001:33:222–9

    Article  CAS  Google Scholar 

  29. Marrollo M, Latella G, Melideo D, Storelli E, Iannarelli R, Stornelli P, Valenti M, Caprilli R. Increased prevalence of Helicobacter pylori in patients with diabetes mellitus. Dig Liver Dis 2001; 33: 21–29

    Article  CAS  PubMed  Google Scholar 

  30. Lip GH, Wise R, Beevers G. Association of Helicobacter pylori infection with coronary heart disease: Study shows association between H. pylori infection and hypertension. BMJ 1996; 312: 250–251

    CAS  PubMed  Google Scholar 

  31. Harvey R, Lane A, Murray L, Harvey I, Nair P, Donovan J. Effect of Helicobacter pylori infection on blood pressure: A community based cross sectional study. BMJ 2001; 323: 264–265

    Article  CAS  PubMed  Google Scholar 

  32. Ekesbo R, Nilsson PM, Lindholm LH, Persson K, Wadstrom T. Combined seropositivity for H. pylori and C. pneumoniae is associated with age, obesity and social factors. J Cardiovasc Risk 2000; 7:191–195

    CAS  PubMed  Google Scholar 

  33. Niemela S, Karttunen T, Korhonen T, Laara E, Karttunen R, Ikaheimo M, Kesäniemi YA. Could Helicobacter pylori infection increase the risk of coronary heart disease by modifying serum lipid concentrations? Heart1996; 75: 573–575

    Article  CAS  PubMed  Google Scholar 

  34. Lu YH, Yen HW, Lin TH, Huang CH, Lee KT, Wang WM, Wu DC, Voon WC, Lai WT, Sheu SH. Changes of coronary risk factors after eradication of Helicobacter pylori infection. Kaohsiung J Med Sci 2002; 18:266–72. [Abs]

    PubMed  Google Scholar 

  35. Singh RK, McMahon AD, Patel H, Packard CJ, Rathbone BJ, Samani NJ. Prospective analysis of the association of infection with CagA bearing strains of Helicobacter pylori and coronary heart disease. Heart 2002; 88:43–6

    Article  CAS  PubMed  Google Scholar 

  36. Pellicano R, Parravicini PP, Bigi R, Gandolfo N, Aruta E, Gai V, Figura N, Angelino P, Rizzetto M, Ponzetto A. Infection by Helicobacter pylori and acute myocardial infarction. Do cytotoxic strains make a difference? New Microbiol 2002; 25:315–21

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Infectious Diseases Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, 1411713138, Tehran, Iran

    Setareh Davoudi & Nasrin Rahimian

  2. Cardiovascular Surgery Department, Tehran Heart Center, Tehran University of Medical Sciences, 1411713138, Tehran, Iran

    Abbas Salehi Omran

  3. Pathology & Laboratory Medicine Department, Tehran Heart Center, Tehran University of Medical Sciences, 1411713138, Tehran, Iran

    Mohammad Ali Boroumand

  4. Clinical research Department, Tehran Heart Center, Tehran University of Medical Sciences, 1411713138, Tehran, Iran

    Soheil Saadat

Authors
  1. Setareh Davoudi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abbas Salehi Omran
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohammad Ali Boroumand
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nasrin Rahimian
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Soheil Saadat
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Abbas Salehi Omran.

About this article

Cite this article

Davoudi, S., Omran, A.S., Boroumand, M.A. et al. Association between Helicobacter. pylori and coronary artery disease. cent.eur.j.med 6, 107–112 (2011). https://doi.org/10.2478/s11536-010-0051-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2478/s11536-010-0051-4

Keywords

Search

Navigation