Neural Development and Stem Cells

1. Front Matter

   Pages i-x

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2. Defining Neural Stem Cells and Their Role in Normal Development of the Nervous System

   • Sally Temple

   Pages 1-28

3. Neural Stem Cells in the Adult Brain

   • Daniel A. Lim, Arturo Alvarez-Buylla

   Pages 29-47

4. Cellular and Molecular Properties of Multipotent Neural Stem Cells Throughout Ontogeny

   • Larysa Halyna Pevny

   Pages 49-65

5. Multipotent Stem Cells in the Embryonic Nervous System

   • Ali Jalali, Michael Bonaguidi, Caitilin Hamill, John A. Kessler

   Pages 67-95

6. Regulation of Neural Stem Cell Death

   • Rizwan S. Akhtar, Kevin A. Roth

   Pages 97-122

7. Neuronal Progenitor Cells of the Mammalian Neonatal Anterior Subventricular Zone

   • Douglas L. Falls, Marla B. Luskin

   Pages 123-142

8. Glial Restricted Precursors

   • Mark Noble, Margot Mayer-Pröschel

   Pages 143-188

9. PNS Precursor Cells in Development and Cancer

   • Houman D. Hemmati, Tanya A. Moreno, Marianne Bronner-Fraser

   Pages 189-217

10. Stem Cells of the Adult Olfactory Epithelium

    • James E. Schwob, Woochan Jang

    Pages 219-233

11. Retinal Stem Cells

    • Ani V. Das, Jackson James, Sreekumaran Edakkot, Iqbal Ahmad

    Pages 235-247

12. Transdifferentiation in the Nervous System

    • Ying Liu, Mahendra S. Rao

    Pages 249-265

13. Neural Progenitor Cells of the Adult Human Brain

    • Steven A. Goldman

    Pages 267-297

14. Embryonic Stem Cells and Neurogenesis

    • Robin L. Wesselschmidt, John W. McDonald

    Pages 299-341

15. Mobilization of Neural Precursors in the Adult Central Nervous System

    • Theo D. Palmer, Fred H. Gage

    Pages 343-369

16. Neural Stem Cells and Transplant Therapy

    • Jaime Imitola, Yang D. Teng, Vaclav Ourednik, Kook In Park, Richard L. Sidman, Evan Y. Snyder

    Pages 371-419

17. Back Matter

    Pages 421-454

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Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system. It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Perhaps the most important advance in our understanding of stem cell behavior has been the realization that regionalization of stem cells occurs early in development and this bias toward differentiation in phe- types of neurons or cells characteristic of a particular part of the brain appears to persist even after prolonged culture. We have therefore included additional chapters on olf- tory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone–derived neural stem cells. It is also now clear from an analysis of mutants and transgenics where the death or self-renewal pa- way is altered that cell death regulates stem cell number. As a consequence, this second edition includes a separate chapter on cell death that summarizes the important changes in the death pathway that occur as stem cells mature. The existing chapters in the book have also been extensively revised and updated by experts who have generously c- tributed their time and expertise. The chapters have been organized along the lines of our understanding of how the nervous system develops (Fig. 1, on p. vi).

• Nervous System
• behavior
• brain
• cell
• cell death
• development
• neural stem cells
• neurons
• stem cells

• National Institute on Aging, Baltimore

  Mahendra S. Rao

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