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Combination Cancer Therapy pp 209–230Cite as

Combinations of Chemotherapy and G3139, an Antisense Bcl-2 Oligonucleotide

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Apoptosis, or programmed cell death, is essential for maintaining homeostasis in multicellular organisms (1). It plays an important role in many physiological processes, especially in the immune and nervous systems, and in development (2,3). Deregulation of apoptosis can lead to autoimmune diseases, cancer, and the clinical manifestations of acquired immunodeficiency syndrome (AIDS) (2).

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Authors and Affiliations

  1. Department of Medical Oncology/Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, NY

    Luba Benimetskaya PhD, Sridhar Mani MD & C. A. Stein MD, PhD

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  1. Luba Benimetskaya PhD
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  2. Sridhar Mani MD
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  3. C. A. Stein MD, PhD
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Editors and Affiliations

  1. Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY

    Gary K. Schwartz MD

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Benimetskaya, L., Mani, S., Stein, C.A. (2005). Combinations of Chemotherapy and G3139, an Antisense Bcl-2 Oligonucleotide. In: Schwartz, G.K. (eds) Combination Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1385/1-59259-864-1:209

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