Abstract
Biological warfare (BW) agents also cause natural human or animal diseases. The natural forms of these agents can often be treated successfully by using specific antimicrobial agents (for example, see Table 1 and Table 2). In many cases, the antimicrobial susceptibilities and perhaps the most efficacious therapy of the resultant infections are well-documented in the scientific literature. For some agents, however, natural susceptibilities and treatments are poorly documented, as is the case for human glanders. And although the development of antimicrobial resistance is a major concern, even for naturally acquired disease, it is far more of a concern for infectious agents developed as biological warfare agents, as recent advances in genetic engineering make intentional production of multiple antibiotic-resistant strains achievable at the microbiology graduate student level.
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References
Mandell, G., Bennett, J., and Dolin, R., (eds.) (2000) Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 5th ed. Churchill Livingstone, New York, pp. 236–253.
Alvarez-Elcoro, S. and Enzler, M. (1999) The macrolides: erythromycin, clarithromycin, and azithromycin. Mayo. Clin. Proc. 74, 613–634.
Patel, R. (1998) Antifungal agents. Part I. Amphotericin B preparations and flucytosine. Mayo. Clin. Proc. 73, 1205–25.
Kasten, M. (1999) Clindamycin, metronidazole, and chloramphenicol. Mayo. Clin. Proc. 74, 825–833.
Edson, R. and Terrell, C. (1999) The aminoglycosides. Mayo. Clin. Proc. 74, 519–528.
Estes, L. (1998) Review of pharmacokinetics and pharmacodynamics of antimicrobial agents. Mayo. Clin. Proc. 73, 1114–1122.
Virk, A. and Steckelberg, J. (2000) Clinical aspects of antimicrobial resistance. Mayo. Clin. Proc. 75, 200–214.
Thompson, R. and Wright, A. (1998) General principles of antimicrobial therapy. Mayo. Clin. Proc. 73, 995–1006.
Cockerill, F. (1998) Conventional and genetic laboratory tests used to guide antimicrobial therapy. Mayo. Clin. Proc. 73, 1007–1021.
Smilack, J. (1999) The tetracyclines. Mayo. Clin. Proc. 74, 727–729.
Hellinger, W. and Brewer, N. (1999) Carbapenems and monobactams: imipenem, meropenem, and aztreonam. Mayo. Clin. Proc. 74, 420–434.
Wright, A. (1999) The penicillins. Mayo. Clin. Proc. 74, 290–307.
Keating, M. (1999) Antiviral agents for non-human immunodeficiency virus infections. Mayo. Clin. Proc. 74, 1266–1283.
Louie, M. and Cockerill, F. (2001) Susceptibility Testing: Phenotypic and Genotypic Tests for Bacteria and Mycobacteria. Infect. Dis. Clin. N. Am. 15.
Doganay, M. and Aydin, N. (1991) Antimicrobial susceptibility of Bacillus anthracis. Scand. J. Infect. Dis. 23, 333–335.
Odendaal, M., Pieterson, P., de, V. V., and Botha, A. (1991) The antibiotic sensitivity patterns of Bacillus anthracis isolated from the Kruger National Park. Onderstepoort. J. Vet. Res. 58, 17–19.
Lightfoot, N. F., Scott, R. J., and Turnbull, P. C. (1990) Antimicrobial susceptibility of Bacillus anthracis: proceedings of the international workshop on anthrax. Salisbury Med. Bull. 68, 95–98.
Heine, H., Dicks, R., and Andrews, G. (2001) In vitro activity of oratavancin (LY33328), levofloxacin, meropenem, GAR936 and linezolid against strains of Bacillus anthracis. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL. 173.
Heine, H., Dicks, R., and Byrne, W. (2000) In vitro activity of daptomycin, sparfloxacin, quinupristin-dalfopristin and other antibiotics against Bacillus anthracis. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto. 167.
Lalitha, M. and Thomas, M. (1997) Penicillin resistance in Bacillus anthracis. Lancet 349, 1522.
Patra, G., Vaissaire, J., Weber-Levy, M., Le, D. C., and Mock, M. (1998) Molecular characterization of Bacillus strains involved in outbreaks of anthrax in France in 1997. J. Clin. Microbiol. 36, 3412–3414.
Bradaric, N. and Punda-Polic, V. (1992) Cutaneous anthrax due to penicillin-resistant Bacillus anthracis transmitted by an insect bite. Lancet 340, 306, 307.
Inglesby, T., O’Toole, T., Henderson, D., et al. (2002) Anthrax as a biological weapon, 2002: updated recommendations for management. JAMA 287, 2236–2252.
Chen, Y., Succi, J., and Koehler, T. M. (2001) Silent β-lactamase Genes in Bacillus anthracis. 4th International Conference on Anthrax. Annapolis, MD.
Penn, C. C. and Klotz, S. A. (1998) Bacillus anthracis and other aerobic spore formers, in Infectious Diseases. 2nd ed. (Blacklow, N. R., ed.), Saunders, Philadelphia, PA, pp. 1747–1750.
Centers for Disease Control and Prevention. (2001) Update: investigation of bioterrorism-related anthrax and interim guidelines for exposure management and antimicrobial therapy, October 2001. [erratum appears in MMWR Morb. Mortal. Wkly. Rep. (2001) 50(43), 962]. MMWR Morb. Mortal. Wkly Rep. 50, 909–919.
Kim, H., Choi, E., and Kim, B. (1993) A macrolide-lincosamide-streptogramin B resistance determinant from Bacillus anthracis 590: cloning and expression of ermJ. J. Gen. Microbiol. 139, 601–607.
Pomerantsev, A., Sukovatova, L., and Marinin, L. (1993) [Characterization of a Rif-R population of Bacillus anthracis]. Antibiot. Khimioter. 38, 34–38.
Pomerantsev, A., Shishkova, N., and Marinin, L. (1992) [Comparison of therapeutic effects of antibiotics of the tetracycline group in the treatment of anthrax caused by a strain inheriting tet-gene of plasmid pBC16]. Antibiot. Khimioter. 37, 31–34.
Stepanov, A. V., Marinin, L. I., Pomerantsev, A. P., and Staritsin, N. A. (1996) Development of novel vaccines against anthrax in man. J. Biotechnol. 44, 155–160.
Brook, I., Elliott, T., Pryor, H., et al. (2001) In vitro resistance of Bacillus anthracis Sterne to doxycycline, macrolides and quinolones. Int. J. Antimicrob. Agents 18, 559–562.
Choe, C., Bouhaouala, S., Brook, I., Elliot, T., and Knudson, G. (2000) In vitro development of resistance to ofloxacin and doxycycline in Bacillus anthracis Sterne. Antimicrob. Agents Chemother. 44, 1766.
Stevens, D., Gibbons, A., Bergstrom, R., and Winn, V. (1988) The Eagle effect revisited: efficacy of clindamycin, erythromycin, and penicillin in the treatment of streptococcal myositis. J. Infect. Dis. 158, 23–28.
Russell, N. and Pachorek, R. (2000) Clindamycin in the treatment of streptococcal and staphylococcal toxic shock syndromes. Ann. Pharmacother. 34, 936–939.
Stevens, D., Bryant, A., and Hackett, S. (1995) Antibiotic effects on bacterial viability, toxin production, and host response. Clin. Infect. Dis. 20(Suppl. 2), S154–157.
Abramova, F. A., Grinberg, L. M., Yampolskaya, O. V., and Walker, D. H. (1993) Pathology of inhalational anthrax in 42 cases from the Sverdlovsk outbreak of 1979. Proc. Natl. Acad. Sci. USA 90, 2291–2294.
Hurewitz, A., Wu, C., Mancuso, P., and Zucker, S. (1993) Tetracycline and doxycycline inhibit pleural fluid metalloproteinases. A possible mechanism for chemical pleurodesis. Chest 103, 1113–1117.
Loebstein, R., Addis, A., Ho, E., et al. Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled study. Antimicrob. Agents Chemother. 42, 1336–1339.
AAP (2003) Redbook: Report of the Committee on Infectious Diseases. 26th ed. Am. Acad. Peds., pp. 693–694.
Burkhardt, J., Walterspiel, J., and Schaad, U. (1997) Quinolone arthropathy in animals versus children. Clin. Infect. Dis. 25, 1196–1204.
Friedlander, A., Welkos, S., Pitt, M., et al. (1993) Postexposure prophylaxis against experimental inhalation anthrax. J. Infect. Dis. 167, 1239–1243.
Henderson, D. W., Peacock, S., and Belton, F. C. (1956) Observations on the prophylaxis of experimental pulmonary anthrax in the monkey. J. Hyg. 54, 28–36.
Kortepeter, M., Christopher, G., Cieslak, T., et al. (eds.) (2001) Medical Management of Biological Casualties Handbook. 4th ed. United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, p. 34.
King, A. (2001) Recommendations for susceptibility tests on fastidious organisms and those requiring special handling. J. Antimicrob. Chemother. 48(Suppl. 1), 77–80.
Hall, W. H. (1990) Modern chemotherapy for brucellosis in humans. [see comments]. Rev. Infect. Dis. 12, 1060–1099.
Mortensen, J. E., Moore, D. G., Clarridge, J. E., and Young, E. J. (1986) Antimicrobial susceptibility of clinical isolates of Brucella. Diag. Microbiol. Infect. Dis. 5, 163–169.
Mateu-de-Antonio, E. and Martin, M. (1995) In vitro efficacy of several antimicrobial combinations against Brucella canis and Brucella melitensis strains isolated from dogs. Vet. Microbiol. 45, 1–10.
Bosch, J., Linares, J., Lopez de Goicoechea, M. J., Ariza, J., Cisnal, M. C., and Martin, R. (1986) In-vitro activity of ciprofloxacin, ceftriaxone and five other antimicrobial agents against 95 strains of Brucella melitensis. J. Antimicrob. Chemother. 17, 459–461.
Memish, Z., Mah, M. W., Al Mahmoud, S., Al Shaalan, M., and Khan, M. Y. (2000) Brucella bacteraemia: clinical and laboratory observations in 160 patients. J. Infect. 40, 59–63.
Trujillano-Martin, I., Garcia-Sanchez, E., Fresnadillo, M., Garcia-Sanchez, J., Garcia-Rodriguez, J., and Montes, M. I. (1999) In vitro activities of five new antimicrobial agents against Brucella melitensis. Int. J. Antimicrob. Agents 12, 185, 186.
Kinsara, A., Al-Mowallad, A., and Osoba, A. (1999) Increasing resistance of Brucellae to co-trimoxazole. Antimicrob. Agents Chemother. 43, 1531.
Lubani, M. M., Dudin, K. I., Sharda, D. C., et al. (1989) A multicenter therapeutic study of 1100 children with brucellosis. Ped. Infect. Dis. J. 8, 75–78.
Ariza, J., Bosch, J., Gudiol, F., Linares, J., Viladrich, P. F., and Martin, R. (1986) Relevance of in vitro antimicrobial susceptibility of Brucella melitensis to relapse rate in human brucellosis. Antimicrob. Agents Chemother. 30, 958–960.
Landinez, R., Linares, J., Loza, E., Martinez-Beltran, J., Martin, R., and Baquero, F. (1992) In vitro activity of azithromycin and tetracycline against 358 clinical isolates of Brucella melitensis. Eur. J. Clin. Microbiol. Infect. Dis. 11, 265–267.
Rolain, J., Maurin, M., and Raoult, D. Bactericidal effect of antibiotics on Bartonella and Brucella spp.: clinical implications. J. Antimicrob. Chemother. 46, 811–814.
Trujillano-Martin, I., Garcia-Sanchez, E., Martinez, I., Fresnadillo, M., Garcia-Sanchez, J., and Garcia-Rodriguez, J. (1999) In vitro activities of six new fluoroquinolones against Brucella melitensis. Antimicrob. Agents Chemother. 43, 194, 195.
Garcia-Rodriguez, J., Garcia, S. J., and Trujillano, I. (1991) Lack of effective bactericidal activity of new quinolones against Brucella spp. Antimicrob. Agents Chemother. 35, 756–759.
Akova, M., Gur, D., Livermore, D., Kocagoz, T., and Akalin, H. (1999) In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs. Antimicrob. Agents Chemother. 43, 1298–1300.
Colmenero, J. D., Fernandez-Gallardo, L. C., Agundez, J. A., Sedeno, J., Benitez, J., and Valverde, E. (1994) Possible implications of doxycycline-rifampin interaction for treatment of brucellosis. Antimicrob. Agents Chemother. 38, 2798–2802.
Montejo, J. M., Alberola, I., Glez-Zarate, P., et al. (1993) Open, randomized therapeutic trial of six antimicrobial regimens in the treatment of human brucellosis. Clin. Infect. Dis. 16, 671–676.
al-Sibai, M., Halim, M., el-Shaker, M., Khan, B., and Qadri, S. (1992) Efficacy of ciprofloxacin for treatment of Brucella melitensis infections. Antimicrob. Agents Chemother. 36, 150–152.
Qadri, S. M., Akhtar, M., Ueno, Y., and al-Sibai, M. B. (1989) Susceptibility of Brucella melitensis to fluoroquinolones. Drugs Under Exp. Clin. Res. 15, 483–485.
(1986) Joint FAO/WHO expert committee on brucellosis. World Health Org. Tech. Rep. Ser. 740, 1–132.
Figueroa, D. R., Rojas, R. L., and Marcano, T. E. (1995) [Brucellosis in pregnancy: course and perinatal results]. Ginecol. Obstet. Mex. 63, 190–195.
Jacobs, F., Abramowicz, D., Vereerstraeten,.P, Le, C. J., Zech, F., and Thys, J. (1990) Brucella endocarditis: the role of combined medical and surgical treatment. Rev. Infect. Dis. 12, 740–744.
Gorelov, V., Gubina, E., Grekova, N., and Skavronskaia, A. (1991) [The possibility of creating a vaccinal strain of Brucella abortus 19-BA with multiple antibiotic resistance]. Zh. Mikrobiol. Epidemiol. Immunobiol. 9, 2–4.
Vasi’lev, N., Oborin, V., Vasi’lev, P., Glushkova, O., Kravets, I., and Levchuk, B. (1989) [Sensitivity spectrum of Francisella tularensis to antibiotics and synthetic antibacterial drugs]. Antibiot. Khimioter. 34, 662–665.
Kudelina, R. and Olsufiev, N. (1980) Sensitivity to macrolide antibiotics and lincomycin in Francisella tularensis holarctica. J. Hyg. Epidemiol. Microbiol. Immunol. 24, 84–91.
Ikaheimo, I., Syrjala, H., Karhukorpi, J., Schildt, R., and Koskela, M. (2000) In vitro antibiotic susceptibility of Francisella tularensis isolated from humans and animals. J. Antimicrob. Chemother. 46, 287–290.
Scheel, O., Hoel, T., Sandvik, T., and Berdal, B. P. (1993) Susceptibility pattern of Scandinavian Francisella tularensis isolates with regard to oral and parenteral antimicrobial agents. APMIS 101, 33–36.
Maurin, M., Mersali, N., and Raoult, D. (2000) Bactericidal activities of antibiotics against intracellular Francisella tularensis. Antimicrob. Agents Chemother. 44, 3428–2431.
Baker, C., Hollis, D., and Thornsberry, C. (1985) Antimicrobial susceptibility testing of Francisella tularensis with a modified Mueller-Hinton broth. J. Clin. Microbiol. 22, 212–215.
Tynkevich, N., Pavlovich, N., and Ryzhko, I. (1990) [Comparative study of the effectiveness of amikacin and streptomycin in experimental tularemia]. Antibiot. Khimioter. 35, 35–37.
Enderlin, G., Morales, L., Jacobs, R. F., and Cross, J. T. (1994) Streptomycin and alternative agents for the treatment of tularemia: review of the literature. Clin. Infect. Dis. 19, 42–47.
Cross, J. T. and Jacobs, R. F. (1993) Tularemia: treatment failures with outpatient use of ceftriaxone. Clin. Infect. Dis. 17, 976–980.
Syrjala, H., Schildt, R., and Raisainen, S. (1991) In vitro susceptibility of Francisella tularensis to fluoroquinolones and treatment of tularemia with norfloxacin and ciprofloxacin. Eur. J. Clin. Microbiol. Infect. Dis. 10, 68–70.
Johansson, A., Berglund, L., Gothefors, L., Sjostedt, A., and Tarnvik, A. (2000) Ciprofloxacin for treatment of tularemia in children. Ped. Infect. Dis. J. 19, 449–453.
Sawyer, W. D., Dangerfield, H. G., Hogge, A. L., and Crozier, D. (1966) Antibiotic prophylaxis and therapy of airborne tularemia. Bacteriol. Rev. 30, 542–550.
Russell, P., Eley, S. M., Fulop, M. J., Bell, D. L., and Titball, R. W. (1998) The efficacy of ciprofloxacin and doxycycline against experimental tularaemia. J. Antimicrob. Chemother. 41, 461–465.
Dennis, D. T., Inglesby, T. V., Henderson, D. A., et al. (2001) Tularemia as a biological weapon: medical and public health management. JAMA 285, 2763–2773.
Alibek, K. (1999) Biohazard. Random House, New York, pp. 157, 160.
Pavlov, V., Mokrievich, A., and Volkovoy, K. (1996) Cryptic plasmid pFNL10 from Francisella novicida-like F6168: the base of plasmid vectors for Francisella tularensis. FEMS Immunol. Med. Microbiol. 13, 253–256.
Kuoppa, K., Forsberg, A., and Norqvist, A. (2001) Construction of a reporter plasmid for screening in vivo promoter activity in Francisella tularensis. FEMS Microbiol. Lett. 205, 77–81.
Kenny, D. J., Russell, P., Rogers, D., Eley, S. M., and Titball, R. W. (1999) In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp. Antimicrob. Agents Chemother. 43, 2773–2775.
Heine, H. S., England, M. J., Waag, D. M., and Byrne, W. R. (2001) In vitro antibiotic susceptibilities of Burkholderia mallei (causative agent of glanders) determined by broth microdilution and E-test. Antimicrob. Agents Chemother. 45, 2119–2121.
Al-Izzi, S. A. and Al-Bassam, L. S. (1989) In vitro susceptibility of Pseudomonas mallei to antimicrobial agents. Comp. Immunol. Microbiol. Infect. Dis. 12, 5–8.
Srinivasan, A., Kraus, C., De, S. D., et al. (2001) Glanders in a military research microbiologist. N. Engl. J. Med. 345, 256–258.
Russell, P., Eley, S., Ellis, J., et al. (2000) Comparison of efficacy of ciprofloxacin and doxycycline against experimental melioidosis and glanders. J. Antimicrob. Chemother. 45, 813–818.
Batmanov, V., Iliukhin, V., Lozovaia, N., and Iakovlev, A. (1996) [Recovery rate in chemotherapy of glanders]. Antibiot. Khimioter. 41, 30–34.
Manzeniuk, I., Dorokhin, V., and Svetoch, E. (1994) [The efficacy of antibacterial preparations against Pseudomonas mallei in in-vitro and in-vivo experiments]. Antibiot. Khimioter. 39, 26–30.
Eickhoff, T. C., Bennett, J. V., Hayes, P. S., and Feeley, J. (1970) Pseudomonas pseudomallei: susceptibility to chemotherapeutic agents. J. Infect. Dis. 121, 95–102.
Kenny, D., Russell, P., Rogers, D., Eley, S., and Titball, R. (1999) In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp. Antimicrob. Agents Chemother. 43, 2773–2775.
Sookpranee, T., Sookpranee, M., Mellencamp, M. A., and Preheim, L. C. (1991) Pseudomonas pseudomallei, a common pathogen in Thailand that is resistant to the bactericidal effects of many antibiotics. Antimicrob. Agents Chemother. 35, 484–489.
Dance, D. A., Wuthiekanun, V., Chaowagul, W., and White, N. J. (1989) The antimicrobial susceptibility of Pseudomonas pseudomallei. Emergence of resistance in vitro and during treatment. J. Antimicrob. Chemother. 24, 295–309.
Cheong, Y. M., Joseph, P. G., and Koay, A. S. (1987) In-vitro susceptibility of Pseudomonas pseudomallei isolated in Malaysia to some new cephalosporins and a quinolone. SE Asian J. Trop. Med. Public Health 18, 94–96.
McEniry, D. W., Gillespie, S. H., and Felmingham, D. (1988) Susceptibility of Pseudomonas pseudomallei to new β-lactam and aminoglycoside antibiotics. J. Antimicrob. Chemother. 21, 171–175.
Jenney, A. W., Lum, G., Fisher, D. A., and Currie, B. J. (2001) Antibiotic susceptibility of Burkholderia pseudomallei from tropical northern Australia and implications for therapy of melioidosis. Int. J. Antimicrob. Agents 17, 109–113.
Koay, A. S., Rohani, M. Y., and Cheong, Y. M. (1997) In-vitro susceptibility of Burkholderia pseudomallei to cefoperazone-sulbactam combination. Med. J. Malaysia 52, 158–160.
Moore, R. A., DeShazer, D., Reckseidler, S., Weissman, A., and Woods, D. E. (1999) Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei. [see comments]. Antimicrob. Agents Chemother. 43, 465–470.
Godfrey, A. J., Wong, S., Dance, D. A., Chaowagul, W., and Bryan, L. E. (1991) Pseudomonas pseudomallei resistance to β-lactam antibiotics due to alterations in the chromosomally encoded β-lactamase. Antimicrob. Agents Chemother. 35, 1635–1640.
Lumbiganon, P., Tattawasatra, U., Chetchotisakd, P., Wongratanacheewin, S., and Thinkhamrop, B. (2000) Comparison between the antimicrobial susceptibility of Burkholderia pseudomallei to trimethoprim-sulfamethoxazole by standard disk diffusion method and by minimal inhibitory concentration determination. J. Med. Assoc. Thailand 83, 856–860.
White, N. J., Dance, D. A., Chaowagul, W., Wattanagoon, Y., Wuthiekanun, V., and Pitakwatchara, N. (1989) Halving of mortality of severe melioidosis by ceftazidime. [see comments]. Lancet 2, 697–701.
Suputtamongkol, Y., Rajchanuwong, A., Chaowagul, W., et al. (1994) Ceftazidime vs. amoxicillin/clavulanate in the treatment of severe melioidosis. Clin. Infect. Dis. 19, 846–853.
Chetchotisakd, P., Porramatikul, S., Mootsikapun, P., Anunnatsiri, S., and Thinkhamrop, B. (2001) Randomized, double-blind, controlled study of cefoperazone-sulbactam plus cotrimoxazole versus ceftazidime plus cotrimoxazole for the treatment of severe melioidosis. Clin. Infect. Dis. 33, 29–34.
Currie, B., Fisher, D., Howard, D., et al. (2000) Endemic melioidosis in tropical northern Australia: a 10-year prospective study and review of the literature. Clin. Infect. Dis. 31, 981–986.
Stephens, D., Fisher, D., and Currie, B. (2002) An audit of the use of granulocyte colony-stimulating factor in septic shock [in process citation]. Intern. Med. J. 32, 143–148
Rajchanuvong, A., Chaowagul, W., Suputtamongkol, Y., Smith, M. D., Dance, D. A., and White, N. J. (1995) A prospective comparison of co-amoxiclav and the combination of chloramphenicol, doxycycline, and co-trimoxazole for the oral maintenance treatment of melioidosis. Trans. Royal Soc. Trop. Med. Hyg. 89, 546–549.
Chetchotisakd, P., Chaowagul, W., Mootsikapun, P., Budhsarawong, D., and Thinkamrop, B. (2001) Maintenance therapy of melioidosis with ciprofloxacin plus azithromycin compared with cotrimoxazole plus doxycycline. Am. J. Trop. Med. Hyg. 64, 24–27.
Samuel, M. and Ti, T. (2001) Interventions for treating melioidosis. Cochrane Database Sys. Rev. CD001263.
Apisarnthanarak, A. and Little, J. (2002) The role of cefoperazone-sulbactam for treatment of severe melioidosis. Clin. Infect. Dis. 34, 721–723.
Simpson, A., Suputtamongkol, Y., Smith, M., et al. (1999) Comparison of imipenem and ceftazidime as therapy for severe melioidosis. Clin. Infect. Dis. 29, 381–387.
Currie, B. J., Fisher, D. A., Anstey, N. M., and Jacups, S. P. (2000) Melioidosis: acute and chronic disease, relapse and re-activation. Trans. Royal Soc. Trop. Med. Hyg. 94, 301–304.
Chanteau, S., Ratsitorahina, M., Rahalison, L., et al. (2000) Current epidemiology of human plague in Madagascar. Microb. Infect. 2, 25–31.
Frean, J. A., Arntzen, L., Capper, T., Bryskier, A., and Klugman, K. P. (1996) In vitro activities of 14 antibiotics against 100 human isolates of Yersinia pestis from a southern African plague focus. Antimicrob. Agents Chemother. 40, 2646, 2647.
Lyamuya, E. F., Nyanda, P., Mohammedali, H., and Mhalu, F. S. (1992) Laboratory studies on Yersinia pestis during the 1991 outbreak of plague in Lushoto, Tanzania. J. Trop. Med. Hyg. 95, 335–338.
Smith, M. D., Vinh, D. X., Nguyen, T. T., Wain, J., Thung, D., and White, N. J. (1995) In vitro antimicrobial susceptibilities of strains of Yersinia pestis. Antimicrob. Agents Chemother. 39, 2153, 2154.
Rasoamanana, B., Coulanges, P., Michel, P., and Rasolofonirina, N. (1989) Sensibilite de Yersinia pestis aux antibiotiques: 277 souches isolees a Madagascar entre 1926 et 1989. Archives de l Institut Pasteur de Madagascar 56, 37–53.
Galenko, G., Akiev, A., and Tarasova, V. (1992) [Antibiotic sensitivity of plague microbe strains from foreign countries]. Antibiot. Khimioter. 37, 23, 24.
Heine, H. (2002) In Unpublished data, Y. pestis MIC Data. (J. B. W., ed.), Fort Detrick, MD.
Galimand, M., Guiyoule, A., Gerbaud, G., et al. (1997) Multidrug resistance in Yersinia pestis mediated by a transferable plasmid. N. Engl. J. Med. 337, 677–680.
Guiyoule, A., Gerbaud, G., Buchrieser, C., et al. (2001) Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis. Emerg. Infect. Dis. 7, 43–48.
(1994) Human plague—United States, 1993–1994. MMWR Morb. Mortal. Wkly. Rep. 43, 242–246.
Welty, T., Grabman, J., Kompare, E., et al. (1985) Nineteen cases of plague in Arizona. A spectrum including ecthyma gangrenosum due to plague and plague in pregnancy. W. J. Med. 142, 641–646.
Byrne, W. R., Welkos, S. L., Pitt, M. L., et al. (1998) Antibiotic treatment of experimental pneumonic plague in mice. Antimicrob. Agents Chemother. 42, 675–681.
Inglesby, T., Dennis, D., Henderson, D., et al. (2000) Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense. JAMA 283, 2281–2290.
Crook, L. D. and Tempest, B. (1992) Plague. A clinical review of 27 cases. Arch. Int. Med. 152, 1253–1256.
Russell, P., Eley, S. M., Green, M., et al. (1998) Efficacy of doxycycline and ciprofloxacin against experimental Yersinia pestis infection. [see comments]. J. Antimicrob. Chemother. 41, 301–305.
Bonacorsi, S. P., Scavizzi, M. R., Guiyoule, A., Amouroux, J. H., and Carniel, E. (1994) Assessment of a fluoroquinolone, three beta-lactams, two aminoglycosides, and a cycline in treatment of murine Yersinia pestis infection. [erratum appears in Antimicrob. Agents Chemother. (1994) 38(7), 1694]. Antimicrob. Agents Chemother. 38, 481–486.
Ryzhko, I., Shcherbaniuk, A., Tsuraeva, R., et al. (1997) [A comparative study of fluoroquinolones and 3rd-generation cephalosporins in the prevention and treatment of experimental plague caused by Yersinia pestis strains typical and serologically atypical with respect to F1]. Antibiot. Khimioter. 42, 12–16.
Ryzhko, I., Samokhodkina, E., Tsuraeva, R., Shcherbaniuk, A., and Pasiukov, V. [Experimental evaluation of prospects for the use of β-lactams in plague infection caused by pathogens with plasmid resistance to penicillins]. Antibiot. Khimioter. 43, 11–15.
Becker, T. M., Poland, J. D., Quan, T. J., White, M. E., Mann, J. M., and Barnes, A. M. (1987) Plague meningitis—a retrospective analysis of cases reported in the United States, 1970–1979. W. J. Med. 147, 554–557.
Ryzhko, I., Shcherbaniuk, A., Samokhodkina, E., et al. (1994) [Virulence of rifampicin and quinolone resistant mutants of strains of plague microbe with Fra+ and Fra− phenotypes]. Antibiot. Khimioter. 39, 32–36.
Yeaman, M. R. and Baca, O. G. (1991) Mechanisms that may account for differential antibiotic susceptibilities among Coxiella burnetii isolates. Antimicrob. Agents Chemother. 35, 948–954.
Raoult, D., Torres, H., and Drancourt, M. (1991) Shell-vial assay: evaluation of a new technique for determining antibiotic susceptibility, tested in 13 isolates of Coxiella burnetii. Antimicrob. Agents Chemother. 35, 2070–2077.
Yeaman, M. R and Baca, O. G. (1990) Unexpected antibiotic susceptibility of a chronic isolate of Coxiella burnetii. Ann. NY Acad. Sci. 590, 297–305.
Yeaman, M. R,. Mitscher, L. A., and Baca, O. G. (1987) In vitro susceptibility of Coxiella burnetii to antibiotics, including several quinolones. Antimicrob. Agents Chemother. 31, 1079–1084.
Gikas, A., Spyridaki, I., Psaroulaki, A., Kofterithis, D., and Tselentis, Y. (1998) In vitro susceptibility of Coxiella burnetii to trovafloxacin in comparison with susceptibilities to pefloxacin, ciprofloxacin, ofloxacin, doxycycline, and clarithromycin. Antimicrob. Agents Chemother. 42, 2747, 2748.
Rolain, J., Maurin, M., and Raoult, D. (2001) Bacteriostatic and bactericidal activities of moxifloxacin against Coxiella burnetii. Antimicrob. Agents Chemother. 45, 301, 302.
Maurin, M. and Raoult, D. (1997) Bacteriostatic and bactericidal activity of levofloxacin against Rickettsia rickettsii, Rickettsia conorii, ‘Israeli spotted fever group rickettsia’ and Coxiella burnetii. J. Antimicrob. Chemother. 39, 725–730.
Keysary, A., Itzhaki, A., Rubinstein, E., Oron, C., and Keren, G. (1996) The in-vitro anti-rickettsial activity of macrolides. J. Antimicrob. Chemother. 38, 727–731.
Maurin, M. and Raoult, D. (1993) In vitro susceptibilities of spotted fever group rickettsiae and Coxiella burnetti to clarithromycin. Antimicrob. Agents Chemother. 37, 2633–2637.
Yeaman, M. R., Roman, M. J., and Baca, O. G. (1989) Antibiotic susceptibilities of two Coxiella burnetii isolates implicated in distinct clinical syndromes. Antimicrob. Agents Chemother. 33, 1052–1057.
Maurin, M., Benoliel, A. M., Bongrand, P., and Raoult, D. (1992) Phagolysosomal alkalinization and the bactericidal effect of antibiotics: the Coxiella burnetii paradigm. J. Infect. Dis. 166, 1097–1102.
Gikas, A., Kofteridis, D., Manios, A., Pediaditis, J., and Tselentis, Y. (2001) Newer macrolides as empiric treatment for acute Q fever infection. Antimicrob. Agents Chemother. 45, 3644–3646.
Perez-del-Molino, A., Aguado, J. M., Riancho, J. A., Sampedro, I., Matorras, P., and Gonzalez-Macias, J. (1991) Erythromycin and the treatment of Coxiella burnetii pneumonia. J. Antimicrob. Chemother. 28, 455–459.
Bertrand, A., Janbon, F., Jonquet, O., and Reynes, J. (1988) [Rickettsiaceae infections and fluoroquinolones]. Pathol. Biol. (Paris) 36, 493–495.
Maurin, M. and Raoult, D. (1999) Q fever. Clin. Microbiol. Rev. 12, 518–553.
Drancourt, M., Raoult, D., Xeridat, B., Milandre, L., Nesri, M., and Dano, P. (1991) Q fever meningoencephalitis in five patients. Eur. J. Epidemiol. 7, 134–138.
Fenollar, F., Fournier, P., Carrieri, M., Habib, G., Messana, T., and Raoult, D. Risks factors and prevention of Q fever endocarditis. Clin. Infect. Dis. 33, 312–316.
Raoult, D., Fenollar, F., and Stein, A. (2002) Q fever during pregnancy: diagnosis, treatment, and follow-up. Arch. Intern. Med. 162, 701–704.
Raoult, D. and Stein, A. (1994) Q fever during pregnancy—a risk for women, fetuses, and obstetricians. N. Engl. J. Med. 330, 371.
Levy, P. Y., Drancourt, M., Etienne, J., et al. (1991) Comparison of different antibiotic regimens for therapy of 32 cases of Q fever endocarditis. Antimicrob. Agents Chemother. 35, 533–537.
Raoult, D., Houpikian, P., Tissot Dupont, H., Riss, J. M., Arditi-Djiane, J., and Brouqui, P. (1999) Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine. Arch. Int. Med. 159, 167–173.
Raoult, D. (1993) Treatment of Q fever. Antimicrob. Agents Chemother. 37, 1733–1736.
Tigertt, W. D. and Benenson, A. S. (1956) Studies on Q fever in man. Trans. Assoc. Am. Phys. 69, 98–104.
Canonico, P. G., Kende, M., Luscri, B. J., and Huggins, J. W. (1984) In-vivo activity of antivirals against exotic RNA viral infections. J. Antimicrob. Chemother. 14(Suppl A), 27–41.
Lukaszewski, R. and Brooks, T. (2000) Pegylated alpha interferon is an effective treatment for virulent venezuelan equine encephalitis virus and has profound effects on the host immune response to infection. J. Virol. 74, 5006–5015.
McCormick, J., King, I., Webb, P., et al. (1986) Lassa fever. Effective therapy with ribavirin. N. Engl. J. Med. 314, 20–26.
Enria, D. A., Briggiler, A. M., Levis, S., Vallejos, D., Maiztegui, J. I., and Canonico, P. G. (1987) Tolerance and antiviral effect of ribavirin in patients with Argentine hemorrhagic fever. Antivir. Res. 7, 353–359.
Enria, D. A. and Maiztegui, J. I. (1994) Antiviral treatment of Argentine hemorrhagic fever. Antivir. Res. 23, 23–31.
Kilgore, P. E., Ksiazek, T. G., Rollin, P. E., et al. (1997) Treatment of Bolivian hemorrhagic fever with intravenous ribavirin. Clin. Infect. Dis. 24, 718–722.
Fisher-Hoch, S., Khan, J., Rehman, S., Mirza, S., Khurshid, M., and McCormick, J. (1995) Crimean Congo-haemorrhagic fever treated with oral ribavirin. Lancet 346, 472–475.
Kende, M., Lupton, H., Rill, W., Levy, H., and Canonico, P. (1987) Enhanced therapeutic efficacy of poly(ICLC) and ribavirin combinations against Rift Valley fever virus infection in mice. Antimicrob. Agents Chemother. 31, 986–990.
Yang, Z. Q., Zhang, T. M., Zhang, M. V., et al. (1991) Interruption study of viremia of patients with hemorrhagic fever with renal syndrome in the febrile phase. Chin. Med. J. 104, 149–153.
Mertz, G. J., Hjelle, B. L., and Bryan, R. T. (1997) Hantavirus infection. Adv. Int. Med. 42, 369–421.
Huggins, J. (1989) Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad-spectrum antiviral drug. Rev. Infect. Dis. 11(Suppl. 4), S750–761.
Bray, M., Driscoll, J., and Huggins, J. W. (2000) Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor. Antivir. Res. 45, 135–147.
Huggins, J., Zhang, Z. X., and Bray, M. (1999) Antiviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse model. J. Infect. Dis. 179(Suppl. 1), S240–247.
Borio, L., Inglesby, T., Peters, C., et al. (2002) Hemorrhagic fever viruses as biological weapons: medical and public health management. JAMA 287, 2391–2405.
De Clercq, E. (2001) Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections. Clin. Microbiol. Rev. 14, 382–397.
Bray, M., Martinez, M., Kefauver, D., West, M., and Roy, C. (2002) Treatment of aerosolized cowpox virus infection in mice with aerosolized cidofovir. Antivir. Res. 54, 129–142.
Bauer, D. (1965) Clinical experience with the antiviral drug marboran (1-methylisatin 3-thiosemicarbazone). Ann. NY Acad. Sci. 130, 110–117.
Koplan, J. P., Monsur, K. A., Foster, S. O., et al. (1975) Treatment of Variola major with adenine arabinoside. J. Infect. Dis. 131, 34–39.
Monsur, K., Hossain, M., Huq, F., Rahaman, M., and Haque, M. (1975) Treatment of Variola major with cytosine arabinoside. J. Infect. Dis. 131, 40–43.
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Woods, J.B. (2005). Antimicrobials for Biological Warfare Agents. In: Lindler, L.E., Lebeda, F.J., Korch, G.W. (eds) Biological Weapons Defense. Infectious Disease. Humana Press. https://doi.org/10.1385/1-59259-764-5:285
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