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Factors Affecting Prognosis of Patients with Giant Cell Tumors of the Mobile Spine: Retrospective Analysis of 102 Patients in a Single Center

  • Bone and Soft Tissue Sarcomas
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Giant cell tumor (GCT) of the mobile spine is a benign tumor, but it can be potentially aggressive. There is not much published information on GCT of the mobile spine as a result of rarity of the disease, and there are controversies over prognostic factors of the condition.

Methods

A retrospective analysis of GCT of the mobile spine was performed by survival analysis. Recurrence-free survival (RFS) was defined as the interval between the date of surgery and the date of recurrence. The postoperative RFS rate was estimated by the Kaplan–Meier method. Factors with P values of ≤0.1 were subjected to multivariate analysis for RFS by proportional hazard analysis. P values of ≤0.5 were considered statistically significant.

Results

A total of 102 patients with GCT of the mobile spine were included in the study. The mean follow-up period was 39.9 (median 26.0, range 2–153) months. Thirty-eight patients developed recurrence. The univariate and multivariate analysis suggested that age less than 40 years, total spondylectomy either by en bloc or piecemeal method, and administration of bisphosphonate were independent favorable prognostic factors. Subgroup analysis by excluding patients before the year 2000 further confirmed our findings.

Conclusions

The removal of the entire osseous compartment either by en bloc or piecemeal method in combination with the long-term use of bisphosphonate could significantly reduce the recurrence rate of GCT of the mobile spine. Age less than 40 years is a favorable prognostic factor for GCT in the mobile spine.

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Acknowledgment

This study was supported in part by the National Natural Science Foundation of China (Grant 81102036).

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Authors and Affiliations

  1. Spine Tumor Center, Changzheng Hospital, Second Military Medical University, Shanghai, China

    Wei Xu MD, Yu Wang MD, Shuai Han MD, Su Chen MD, Leqin Xu MD, Xinghai Yang MD, Tielong Liu MD & Jianru Xiao MD

  2. Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai, China

    Xiang Li MD

  3. Department of Orthopedics, No. 411 Hospital of PLA, Shanghai, China

    Wending Huang MD

Authors
  1. Wei Xu MD
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  2. Xiang Li MD
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  3. Wending Huang MD
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  4. Yu Wang MD
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  5. Shuai Han MD
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  6. Su Chen MD
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  7. Leqin Xu MD
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  8. Xinghai Yang MD
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  10. Jianru Xiao MD
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Corresponding author

Correspondence to Jianru Xiao MD.

Additional information

Wei Xu, Xiang Li and Wending Huang contributed equally to this study, and all should be considered first author.

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Xu, W., Li, X., Huang, W. et al. Factors Affecting Prognosis of Patients with Giant Cell Tumors of the Mobile Spine: Retrospective Analysis of 102 Patients in a Single Center. Ann Surg Oncol 20, 804–810 (2013). https://doi.org/10.1245/s10434-012-2707-6

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  • DOI: https://doi.org/10.1245/s10434-012-2707-6

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