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Impact of Anti-tacking Agents on Properties of Gas-Entrapped Membrane and Effervescent Floating Tablets

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Abstract

Tackiness caused by the gas-entrapped membrane (Eudragit®RL 30D) was usually observed during storage of the effervescent floating tablets, leading to failure in floatation and sustained release. In this work, common anti-tacking agents (glyceryl monostearate (GMS) and talc) were used to solve this tackiness problem. The impact of anti-tacking agent on the properties of free films and corresponding floating tablets was investigated. GMS was more effective than talc in reducing tackiness of the film. Addition and increasing amount of anti-tacking agents lowered the film mechanical strength, but the coating films were still strong and flexible enough to resist the generated gas pressure inside the floating tablet. Wettability and water vapor permeability of the film decreased with increasing level of anti-tacking agents as a result of their hydrophobicity. No interaction between anti-tacking agents and polymer was observed as confirmed by Fourier transform infrared spectroscopy, powder X-ray diffractometry, and differential scanning calorimetry studies. Increasing amount of anti-tacking agents decreased time to float and tended to retard drug release of the floating tablets. Floating properties and drug release were also influenced by type of anti-tacking agents. The obtained floating tablets still possessed good floating properties and controlled drug release even though anti-tacking agent had some effects. The results demonstrated that the tackiness problem of the floating tablets could be solved by incorporating anti-tacking agent into the gas-entrapped membrane.

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Acknowledgments

This work was financially supported by the Thailand Research Fund (Grant no. DBG5280007), the Royal Golden Jubilee Ph.D. Program (Grant No. PHD/0340/2551) under the Thailand Research Fund (TRF), Thailand.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok-Nakhonsawan Road, Phitsanulok, 65000, Thailand

    Worawut Kriangkrai & Srisagul Sungthongjeen

  2. Department of Manufacturing Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand

    Satit Puttipipatkhachorn

  3. Center of Excellence in Innovative Drug Delivery and Nanomedicine, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand

    Satit Puttipipatkhachorn

  4. Department of Pharmaceutical Technology and Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand

    Pornsak Sriamornsak

  5. Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand

    Thaned Pongjanyakul

Authors
  1. Worawut Kriangkrai
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  2. Satit Puttipipatkhachorn
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  3. Pornsak Sriamornsak
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  4. Thaned Pongjanyakul
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  5. Srisagul Sungthongjeen
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Correspondence to Srisagul Sungthongjeen.

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Kriangkrai, W., Puttipipatkhachorn, S., Sriamornsak, P. et al. Impact of Anti-tacking Agents on Properties of Gas-Entrapped Membrane and Effervescent Floating Tablets. AAPS PharmSciTech 15, 1357–1369 (2014). https://doi.org/10.1208/s12249-014-0161-4

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  • DOI: https://doi.org/10.1208/s12249-014-0161-4

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