Abstract
A methanol extract of Combretum micranthum leaves was studied for anti-inflammatory activity in rats and mice using the carrageenan-induced rat paw oedema and the acetic acid-induced vascular permeability in mice. The effect of the extract on cellular-type inflammation was also investigated in the cotton pellet granuloma in rats. The extract (50, 100 mg/kg) significantly (P < 0.05) inhibited oedema production induced by carrageenan in rats. Increased vascular permeability caused by acetic acid injection was also inhibited by the extract, within the same dose range. C. micranthum extract (100 mg/kg) inhibited granuloma formation in rats to a similar degree as indomethacin (5 mg/kg). These results provide evidence for the anti-inflammatory property of C. micranthum leaves.
This is a preview of subscription content, log in via an institution to check access.
REFERENCES
Bassene, E., Olschwang, D. and Pousset, J. L. (1987). African medicinal plants. XXIII. Flavonoids of Combretum micranthum G. Don (Kinkeliba), Plant Med. Phytother. 21, 173–175.
Benoit, F., Valentin, A., Pelissier, Y., et al. (1996). In vitro antimalarial activity of vegetal extracts used in west African traditional medicine, Am. J. Trop. Med. Hygiene 54, 67–71.
Comley, J. C. W. (1990). New macrofilaricidal leads from plants? Trop. Med. Parasitol. 41, 1–9.
D'Agostino, M., Biagi, C., De Feo, V., et al. (1990). Flavonoids of Combretum micranthum.Fitoterapia 61, 477.
Di Carlo, F. J., Haynes, L. J., Sliver, N. J., et al. (1964). Reticuloendothelial system stimulants of botanical origin, J. Reticuloendothelial Soc. 1, 224.
Di Rosa, M., Giroud, J. P. and Willoughby, D. A. (1971). Studies of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine, J. Pathol. 104, 15–29.
Le Grand, A. (1989). Anti-infectious phytotherapy of the tree-savanna Senegal (West Africa). III: A review of the phytochemical substances and antimicrobial activity of 43 species, J. Ethnopharmacol. 25, 315–338.
Le Grand, A. and Wondergem, P. A. (1987). Antiinfective phytotherapy of the savanna forests of Senegal (West Africa) I. An inventory, J. Ethnopharmacol. 21, 109–125.
Mossa, J. S., Rafatullah, S., Galal, A. M., et al. (1995). Pharmacological studies of Rhus retinorrhaea, Int. J. Pharmacogn. 33, 242–246.
Olajide, O. A., Awe, S. O. and Makinde, J. M. (1999). Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-inducedoedema and granuloma tissue formation in rats and mice, J. Ethnopharmacol. 66, 113–117.
Olajide, O. A., Awe, S. O., Makinde, J. M., et al. (2000). Studies on the anti-in' ammatory, antipyretic and analgesic properties of Alstonia boonei stem bark, J. Ethnopharmacol. 71, 179–186.
Swingle, K. F. and Shideman, F. E. (1972). Phases of inflammatory response to subcutaneous implantation of cotton pellet and other modi" cations by certain anti-in' ammatory agents, J. Pharmacol. Exp. Ther. 183, 226–234.
Tignokpa, M., Laurens, A., Mboup, S. et al. (1986). Popular medicinal plants of the markets of Dakar (Senegal), Int. J. Crude Drug Res. 24, 75–80.
Trease, G. E. and Evans, M. C. (1983). Textbook of Pharmacognosy, 12th edn, pp. 43–383. Ballière-Tidal, London.
Whittle, B. A. (1964) The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesic, Brit. J. Pharmacol. Chemother. 22, 246–253.
Winter, C. A., Risley, E. A. and Nuss, C.W. (1962). Carrageenan induced oedema in the hind paw of the rat as an assay for anti-inflammatory drugs, Proc. Soc. Exp. Biol. Med. 111, 544–547.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Olajide, O.A., Makinde, J.M. & Okpako, D.T. Evaluation of the anti-inflammatory property of the extract of Combretum micranthum G. Don (Combretaceae). Inflammopharmacology 11, 293–298 (2003). https://doi.org/10.1163/156856003322315631
Issue Date:
DOI: https://doi.org/10.1163/156856003322315631