Abstract
The connectome is a wiring diagram mapping all the neural connections in the brain. At the cellular level, it provides a map of the neurons and synapses within a part or all of the brain of an organism. In recent years, significant advances have been made in the study of the connectome via network science and graph theory. This analysis is fundamental to understand neurotransmission (fast synaptic transmission) networks. However, neurons use other forms of communication as neuromodulation that, instead of conveying excitation or inhibition, change neuronal and synaptic properties. This additional neuromodulatory layers condition and reconfigure the connectome. In this paper, we propose that multilayer adaptive networks, in which different synaptic and neurochemical layers interact, are the appropriate framework to explain neuronal processing. Then, we describe a simplified multilayer adaptive network model that accounts for these extra-layers of interaction and analyse the emergence of interesting computational capabilities.
Similar content being viewed by others
References
O. Sporns, G. Tononi, R. Kötter, PLoS Computat. Biol. 1, e42 (2005)
A.M. Zador, J. Dubnau, H.K. Oyibo, H. Zhan, G. Cao, I.D. Peikon, PLoS Biol. 10, e1001411 (2012)
A. Horn, D. Ostwald, M. Reisert, F. Blankenburg, NeuroImage 102, 142 (2014)
D.J. Felleman, D.C. Van Essen, Cereb. Cortex 1, 1 (1991)
W. Gerstner, W. Kistler, R. Naud, L. Paninski, Neuronal Dynamics (Cambridge University Press, Cambridge, UK, 2014)
C. Bargmann, E. Marder, Nat. Methods 10, 483 (2013)
C. Bargmann, BioEssays 34, 458 (2012)
V. Brezina, Philos. Trans. R. Soc. B 365, 2363 (2010)
E. Marder, Neuron 76, 1 (2012)
D. Bucher, E. Marder, Cell 155, 482 (2013)
J.G. White, E. Southgate, J.N. Thomson, S. Brenner, Philos. Trans. R. Soc. Lond. B 314, 1 (1986)
L.R. Varshney, B.L. Chen, E. Paniagua, D.H. Hall, D.B. Chklovskii, PLoS Computat. Biol. 7, e1001066 (2011)
S. Achard, E. Bullmore, PLoS Computat. Biol. 3, e17 (2007)
A.P. Alivisatos, M. Chun, G.M. Church, R.J. Greenspan, M.L. Roukes, R. Yuste, Neuron 74, 970 (2012)
A.F. Alexander-Bloch, P.E. Vértes, R. Stidd, F. Lalonde, L. Clasen, J. Rapoport, J. Giedd, E.T. Bullmore, N. Gogtay, Cereb. Cortex 23, 127 (2013)
S.T. Baker, D.I. Lubman, M. Yücel, N.B. Allen, S. Whittle, B.D. Fulcher, A. Zalesky, A. Fornito, J. Neurosci. 35, 9078 (2015)
L. Barnett, C.L. Buckley, S. Bullock, Phys. Rev. E 79, 051914 (2009)
V. Nicosia, P.E. Vértes, W.R. Schafer, V. Latora, E.T. Bullmore, PNAS 110, 7880 (2013)
E.K. Towlson, P.E. Vértes, S.E. Ahnert, W.R. Schafer, E.T. Bullmore, J. Neurosci. 33, 6380 (2013)
F. Nadim, D. Bucher, Curr. Opin. Neurobiol. 29, 48 (2014)
F. Fröhlich, Network Neuroscience (Academic Press, London, 2016)
A. Fornito, A. Zalesky, E. Bullmore, Fundamentals of Brain Network Analysis (Academic Press, London, 2016)
H. Sayama, I. Pestov, J. Schmidt, B.J. Bush, C. Wong, J. Yamanoi, T. Gross, Comput. Math. Appl. 65, 1645 (2013)
O.V. Maslennikov, V.I. Nekorkin, Physics-Uspekhi 60, 694 (2017)
M. Wiedermann, J.F. Donges, J. Heitzig, W. Lucht, J. Kurths, Phys. Rev. E 91, 052801 (2015)
T. Aoki, L.E.C. Rocha, T. Gross, Phys. Rev. E 93, 040301 (2016)
T. Aoki, K. Yawata, T. Aoyagi, Phys. Rev. E 91, 012908 (2015)
M. Kivelä, A. Arenas, M. Barthelemy, J.P. Gleeson, Y. Moreno, M.A. Porter, J. Complex Netw. 2, 203 (2014)
M. De Domenico, C. Granell, M.A. Porter, A. Arenas, Nat. Phys. 12, 901 (2016)
M. De Domenico, Gigascience 6, 1 (2017)
G. Menichetti, D. Remondini, P. Panzarasa, R.J. Mondragón, G. Bianconi, PLoS One 9, e97857 (2014)
N. Kopell, H.J. Gritton, M.A. Whittington, M.A. Kramer, Neuron 83, 1319 (2014)
N. Daur, F. Nadim, D. Bucher, Curr. Opin. Neurobiol. 41, 1 (2016)
B. Bentley, R. Branicky, C.L. Barnes, Y.L. Chew, E. Yemini, E.T. Bullmore, P.E. Vértes, W.R. Schafer, PLoS Computat. Biol. 12, e1005283 (2016)
A.L. Hodgkin, A.F. Huxley, J. Physiol. 117, 500 (1952)
W.S. McCulloch, W. Pitts, Bull. Math. Biophys. 5, 115 (1943)
X. Li, Q. Chen, F. Xue, Philos. Trans. R. Soc. A 375, 20160286 (2017)
O.V. Maslennikov, D.S. Shchapin, V.I. Nekorkin, Philos. Trans. R. Soc. A 375, 20160288 (2017)
J.M. Fellous, C. Linster, Neural Comput. 10, 771 (1998)
A.J. Yu, Computational models of neuromodulation, in Encyclopedia of Computational Neuroscience, edited by D. Jaeger, R. Jung (Springer, New York, 2014)
K. Doya, Nat. Neurosci. 11, 410 (2008)
K. Doya, Neural Netw. 15, 495 (2002)
R. Holca-Lamarre, J. Lücke, K. Obermayer, Front. Comput. Neurosci. 11, 54 (2017)
G.J. Gutierrez, E. Marder, eNeuro 1, ENEURO.0009-14 (2014)
T. O’Leary, A.H. Williams, J.S. Caplan, E. Marder, PNAS 110, E2645 (2013)
E. Marder, M.L. Goeritz, A.G. Otopalik, Curr. Opin. Neurobiol. 31, 156 (2015)
J.A. Reggia, E. Ruppin, D. Glanzman (eds.), Disorders of Brain, Behavior and Cognition: the Neurocomputational Perspective (Elsevier Science, Amsterdam, 1999)
R. Chaudhuri, I. Fiete, Nat. Neurosci. 19, 394 (2016)
S. Tonegawa, M. Pignatelli, D.S. Roy, T.J. Ryan, Curr. Opin. Neurobiol. 35, 101 (2015)
T.J. Ryan, D.S. Roy, M. Pignatelli, A. Arons, S. Tonegawa, Science 348, 1007 (2015)
H.K. Titley, N. Brunel, C. Hansel, Neuron 95, 19 (2017)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hernández, A., Amigó, J.M. Multilayer adaptive networks in neuronal processing. Eur. Phys. J. Spec. Top. 227, 1039–1049 (2018). https://doi.org/10.1140/epjst/e2018-800037-y
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1140/epjst/e2018-800037-y