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Recent advances in the development of ultrafast electronic circular dichroism for probing the conformational dynamics of biomolecules in solution

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Abstract

Conformational dynamics of biomolecules, which can span very large time scales ranging from seconds down to femtoseconds, play a key role in their function. In this regard, the combination of the high temporal resolution of ultrafast pump–probe spectroscopy and the structural sensitivity of electronic circular dichroism (CD) spectroscopy provides an extremely promising tool to follow these dynamics with a "virtually" unlimited temporal resolution. However, although CD spectroscopy is a widely used tool in structural biology to determine the secondary structure of biomolecules in solution, transposition of these measurements to the time domain (TRCD), on the sub-picosecond time scale, remains very challenging due to their weak signals prone to pump-induced polarization artifacts. Recent advances in laser technologies and non-linear optics, however, offer new perspectives for the development of femtosecond TRCD set-ups. In this review, we present recent developments in ultrafast TRCD spectroscopy. We discuss the advantages and drawbacks of the few existing functional experimental set-ups for their use to access the conformational dynamics of biomolecules at ultrashort time scales.

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Fig. 1
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Adapted from X. Xie, J. D. Simon, Rev. Sci. Instrum. 60, 2614 (1989) with the permission of AIP Publishing

Fig. 5

Reproduced from E. Chen, R. A. Goldbeck, D. S. Kliger, Methods 52, 3 (2010) with the permission of Elsevier

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Reproduced from Trifonov A., Buchvarov I., Lorh A., Würthner F., Fiebig T. Rev. Sci. Instrum. 81, 043,104 (2010) with the permission of AIP Publishing

Fig. 7

Reproduced with permission from Oppermann M., Bauer B., Rossi T., Zinna F., Helbing J., Lacour J., Chergui M. Optica 6, 56 (2019), https://doi.org/10.1364/OPTICA.6.000056 © The Optical Society

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Reproduced with permission from Hache F., Niezborala C., J. Opt. Soc. Am. 23, 2418 (2006), https://doi.org/10.1364/JOSAB.23.002418 © The Optical Society

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Copyright 2013 American Chemical Society

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Reproduced from H. Rhee, J. S. Choi, D. J. Starling, J. C. Howelld, M. Cho, Chem. Sci., 4, 4107 (2013) with permission from the Royal Society of Chemistry

Fig. 12

Reproduced from H. Rhee, J. S. Choi, D. J. Starling, J. C. Howelld, M. Cho, Chem. Sci., 4, 4107 (2013) with permission from the Royal Society of Chemistry

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Acknowledgements

The authors thank F. Wien from DISCO beamline at Synchrotron Soleil for his assistance for the SRCD measurement of G-quadruplexes (proposals 20170318 and 20201655).

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  1. Laboratoire d’Optique et Biosciences, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128, Palaiseau, France

    Pascale Changenet & François Hache

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  1. Pascale Changenet
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  2. François Hache
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Correspondence to Pascale Changenet.

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The original online version of this article was revised due to some minor errors in the equations 2, 15, 16 and 17.

Ultrafast Phenomena from attosecond to picosecond timescales: theory and experiments. Guest editors: Franck Lépine, Lionel Poisson.

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Changenet, P., Hache, F. Recent advances in the development of ultrafast electronic circular dichroism for probing the conformational dynamics of biomolecules in solution. Eur. Phys. J. Spec. Top. 232, 2117–2129 (2023). https://doi.org/10.1140/epjs/s11734-022-00679-3

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