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Strengthen the circadian rhythms by the mathematical model of the SCN

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Abstract

The master clock, located in the suprachiasmatic nucleus, controls the circadian rhythms of mammals. Exposed to a natural light–dark cycle or under constant darkness, the circadian rhythms of the SCN are robust. Under special conditions, such as under constant light, after jet-lag and in aging, the rhythm is deteriorated due to being out of synchronization of the SCN neurons or the deteriorated rhythms in individual neurons. In the present article, we review the methods for strengthening the circadian rhythms (i.e., increasing the amplitude) of the SCN network based on the mathematical models, including the application of noise, the heterogeneity in the neuronal properties, and the heterogeneity in the network structure. These models shed light on the understanding the existence of heterogeneity in the SCN and provide alternatives to strengthen the SCN rhythm.

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Acknowledgements

This work is supported by the National Natural Science Foundation of China under Grant nos. 11875042 (C. Gu) and 11505114 (C.Gu), Natural Science Foundation of Shanghai (Grant no. 21ZR1443900), and the Shanghai Project for Construction of Top Disciplines under Grant no. USST-SYS01 (H. Yang and C. Gu).

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Authors and Affiliations

  1. Business School, University of Shanghai for Science and Technology, Shanghai, 200093, People’s Republic of China

    Changgui Gu, Jiahui Li, Jian Zhou & Huijie Yang

  2. School of Foreign Languages, Qingdao University, Qingdao, 266000, People’s Republic of China

    Man Wang

Authors
  1. Changgui Gu
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  2. Jiahui Li
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  3. Jian Zhou
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  4. Huijie Yang
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  5. Man Wang
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Correspondence to Changgui Gu.

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Gu, C., Li, J., Zhou, J. et al. Strengthen the circadian rhythms by the mathematical model of the SCN. Eur. Phys. J. Spec. Top. 231, 827–832 (2022). https://doi.org/10.1140/epjs/s11734-021-00310-x

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  • DOI: https://doi.org/10.1140/epjs/s11734-021-00310-x

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