Skip to main content
Log in

Periodic orbits in glycolytic oscillators: From elliptic orbits to relaxation oscillations

  • Regular Article
  • Published:
The European Physical Journal E Aims and scope Submit manuscript

Abstract.

We consider the Sel’kov model of glycolytic oscillator for a quantitative study of the limit cycle oscillations in the system. We identify a region of parameter space where perturbation theory holds and use both Linstedt Poincaré technique and harmonic balance to obtain the shape and frequency of the limit cycle. The agreement with the numerically obtained result is excellent. We also find a different extreme, where the limit cycle is of the relaxation oscillator variety, has a large time period and it is seen that, as a particular parameter in the model is varied, the time period increases indefinitely. We characterize this divergence numerically. A calculational method is devised to capture the divergence approximately.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. A.T. Winfree, The Geometry of Biological Time (Springer, New York, 2001)

  2. A. Goldbeter, Nature (London) 420, 238 (2002)

    Article  ADS  Google Scholar 

  3. E.E. Sel’kov, Eur. J. Biochem. 4, 79 (1968)

    Article  Google Scholar 

  4. E. Di Cera, P.E. Phillipson, J. Wyman, Proc. Natl. Acad. Sci. U.S.A. 86, 142 (1989)

    Article  MathSciNet  ADS  Google Scholar 

  5. J. Yang, L. Yang, Z. Qu, J.N. Weisi, J. Biol. Chem. 283, 36321 (2008)

    Article  Google Scholar 

  6. S. Kar, D.S. Ray, J. Theor. Biol. 237, 58 (2005)

    Article  MathSciNet  Google Scholar 

  7. S. Kar, D.S. Ray, Phys. Rev. Lett. 90, 238102 (2003)

    Article  ADS  Google Scholar 

  8. F.A. Chandra, G. Buzi, J.C. Doyle, American Control Conference, ACC ’09 (2009), pp. 319-324

  9. P. Ruoff, M.K. Christensen, J. Wolf, R. Heinrich, J. Biol. Chem. 106, 179 (2003)

    Google Scholar 

  10. P. Goel, A. Sherman, SIAM J. Appl. Dyn. Syst. 8, 1664 (2009)

    Article  MathSciNet  ADS  MATH  Google Scholar 

  11. S. Danø, M.F. Madsen, P.G. Sørensen, Proc. Natl. Acad. Sci. U.S.A. 104, 12732 (2007)

    Article  ADS  Google Scholar 

  12. V.K. Vanag, D.G. Míguez, I.R. Epstein, J. Chem. Phys. 125, 194515 (2006)

    Article  ADS  Google Scholar 

  13. T. Mair, C. Warnke, K. Tsuji, S.C. Muller, J. Biophys. 88, 639 (2005)

    Article  Google Scholar 

  14. P.O. Westermark, A. Lansner, J. Biophys. 85, 126 (2003)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T. Roy.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Roy, T., Bhattacharjee, J.K. & Mallik, A.K. Periodic orbits in glycolytic oscillators: From elliptic orbits to relaxation oscillations. Eur. Phys. J. E 34, 19 (2011). https://doi.org/10.1140/epje/i2011-11019-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1140/epje/i2011-11019-6

Keywords

Navigation