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Effects of NO-synthase inhibitors on maturation mouse oocytes in cumulus-oocyte complexes

  • Gametogenesis
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Abstract

We studied the effects of various NO-synthase inhibitors on meiotic maturation of mouse oocytes in vitro in cumulus-oocyte complexes isolated from follicles of varying sizes. Selective and nonselective inhibitors of NO-synthase isoforms suppressed meiotic maturation of oocytes to varying degrees, which was expressed in a decreased number of oocytes at metaphase II. The results obtained suggest that the role of inducible form of NO-synthase (iNOS) increases with the development of follicles and oocytes.

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Authors and Affiliations

  1. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, ul. Bogomol’tsa 4, Kiev, 01024, Ukraine

    T. Yu. Voznesenskaya & T. V. Blashkiv

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  1. T. Yu. Voznesenskaya
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  2. T. V. Blashkiv
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Original Russian Text © T.Yu. Voznesenskaya, T.V. Blashkiv, 2006, published in Ontogenez, 2006, Vol. 37, No. 6, pp. 465–468.

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Voznesenskaya, T.Y., Blashkiv, T.V. Effects of NO-synthase inhibitors on maturation mouse oocytes in cumulus-oocyte complexes. Russ J Dev Biol 37, 389–392 (2006). https://doi.org/10.1134/S1062360406060087

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  • DOI: https://doi.org/10.1134/S1062360406060087

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