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Linkage disequilibrium analysis for microsatellite loci in six cattle breeds

  • Animal Genetics
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Abstract

Autosomal microsatellites are valuable tools for investigating genetic diversity and population structure and making conservation decisions to preserve valuable breeds of domestic animals. We carried out a linkage disequilibrium analysis using 29 microsatellite markers in six cattle populations: Suksun, Istoben, Yaroslavl, Kholmogory, Grey Ukrainian and Pechora type of Khologory cattle. We discovered a significant linkage disequilibrium between microsatellites INRA037 and CSRM60 in Grey Ukrainian cattle.

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References

  1. Lander, E.S. and Botstein, D., Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps, Genetics, 1989, vol. 121, no. 1, pp. 185–190.

    CAS  PubMed Central  PubMed  Google Scholar 

  2. Lander, E. and Kruglyak, L., Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results, Nat. Genet., 1995, vol. 11, no. 3, pp. 241–247.

    Article  CAS  PubMed  Google Scholar 

  3. Georges, M., Nielsen, D., Mackinon, M., et al., Mapping quantitative trait loci controlling milk production in dairy cattle by exploiting progeny testing, Genetics, 1995, vol. 139, no. 2, pp. 907–920.

    CAS  PubMed Central  PubMed  Google Scholar 

  4. Weller, J.I., Introduction to QTL detection and marker-assisted selection, in Biotechnology’s Role in the Genetic Improvement of Farm Animals (Proc. Symp. Agric. Res. 20), Savoy, IL: American Society of Animal Science, 1996, pp. 259–275.

    Google Scholar 

  5. Hayes, B.J., Moen, T., and Goddard, M.E., Dissection of complex traits in livestock and aquaculture species, AgBiotechNet, 2005, vol. 7, ABN 136, p. 10.

  6. Trifonova, E.A., Linkage disequilibrium of the MTHFR gene in populations of Northern Eurasia and among patients with coronary atherosclerosis, Cand. Sci. (Med.) Dissertation, Tomsk: Research Institute of Medical Genetics, 2009.

    Google Scholar 

  7. Patil, N., Berno, A.J., Hinds, D.A., et al., Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21, Science, 2001, vol. 294, no. 5547, pp. 1719–1723.

    Article  CAS  PubMed  Google Scholar 

  8. Shifman, S., Kuypers, J., Kokoris, M., et al., Linkage disequilibrium patterns of the human genome across populations, Hum. Mol. Genet., 2003, vol. 12, no. 7, pp. 771–776.

    Article  CAS  PubMed  Google Scholar 

  9. Rana, N.A., Ebenezer, N.D., Webster, A.R., et al., Recombination hotspots and block structure of linkage disequilibrium in the human genome exemplified by detailed analysis of PGM1 on lp31, Hum. Mol. Genet., 2004, vol. 13, no. 24, pp. 3089–3102.

    Article  CAS  PubMed  Google Scholar 

  10. Linkage Disequilibrium and Association Mapping: Analysis and Applications, Collins, A.R., Ed., vol. 376 of Methods in Molecular Biology, Totowa, NJ: Humana, 2007.

    Google Scholar 

  11. Akul’chenko, Yu.S., Elaboration and application of the genome-wide genetic association analysis of complex traits, Doctoral (Biol.) Dissertation, Novosibirsk: Institute of Cytology and Genetics, 2010.

    Google Scholar 

  12. Aksenovich, T.I., Mapping of genes, determining human disease distribution, Med. Genet., 2006, no. 2, pp. 11–15.

    Google Scholar 

  13. Tenesa, A., Knott, S.A., Ward, D., et al., Estimation of linkage disequilibrium in a sample of the United Kingdom dairy cattle population using unphased genotypes, J. Anim. Sci., 2003, vol. 81, no. 3, pp. 617–623.

    CAS  PubMed  Google Scholar 

  14. Bolormaa, S., Hayes, B.J., Savin, K., et al., Genomewide association studies for feedlot and growth traits in cattle, J. Anim. Sci., 2011, vol. 89, no. 6, pp. 1–37.

    Article  Google Scholar 

  15. Khatkar, M.S., Thomson, P.C., Tammen, I., et al., Linkage disequilibrium on chromosome 6 in Australian Holstein-Friesian cattle, Genet. Sel. Evol., 2006, vol. 38, no. 5, pp. 463–477.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Du, F.-X., Clutter, A.C., and Lohuis, M.M., Characterizing linkage disequilibrium in pig population, Int. J. Biol. Sci., 2007, vol. 3, no. 3, pp. 166–178.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Bozkaya, F. and Kurar, E., Linkage disequilibrium between MHC-linked microsatellite loci in white karaman, awassi and merinolandschaf sheep breeds, Fyrat Univ. Saglik Bilimlery Dergisi, 2005, vol. 19, no. 1, pp. 57–61.

    Google Scholar 

  18. Andreescu, C., Avendano, S., Brown, S., et al., Linkage disequilibrium in related breeding lines of chickens, Genetics, 2007, vol. 177, no. 4, pp. 2161–2169.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Chernyshova, A., Identification of genetic markers, linked with susceptibility to diabetes mellitus type 1, on chromosomes 1, 2, 5 and 16, Cand. Sci. (Biol.) Dissertation, Moscow: State Research Institute of Genetics and Breeding of Industrial Microorganisms, 2007.

    Google Scholar 

  20. Bulmer, M.G., The effect of selection on genetic variability, Am. Nat., 1971, vol. 105, no. 943, pp. 201–211.

    Article  Google Scholar 

  21. Sved, J., Linkage disequilibrium and homozygosity of chromosome segments in finite populations, Theor. Popul. Biol., 2001, vol. 2, no. 2, pp. 125–141.

    Article  Google Scholar 

  22. Farnir, F., Coppieters, W., Arranz, J., et al., Extensive genome-wide linkage disequilibrium in cattle, Genome Res., 2000, vol. 10, no. 2, pp. 220–227.

    Article  CAS  PubMed  Google Scholar 

  23. Bishop, M.D., Kappes, S.M., Keele, J.W., et al., A genetic linkage map for cattle, Genetics, 1994, vol. 136, no. 2, pp. 619–639.

    CAS  PubMed Central  PubMed  Google Scholar 

  24. Toldo, S.S., Fries, R., Steffen, P., et al., Physically mapped, cosmid-derived microsatellite markers as anchor loci on bovine chromosomes, Mamm. Genome, 1993, vol. 4, no. 12, pp. 720–727.

    Article  CAS  PubMed  Google Scholar 

  25. Steffen, P., Eggen, A., Dietz, A.B., et al., Isolation and mapping of polymorphic microsatellites in cattle, Anim. Genet., 1993, vol. 24, no. 2, pp. 121–124.

    Article  CAS  PubMed  Google Scholar 

  26. Kaukinen, J. and Varvio, S.L., Eight polymorphic bovine microsatellites, Anim. Genet., 1993, vol. 24, no. 2, p. 148.

    Google Scholar 

  27. Brezinsky, L.S., Kemp, J., and Teale, A.J., ILSTS005: a polymorphic bovine microsatellite, Anim. Genet., 1993a, vol. 24, no. 1, p. 73.

    Google Scholar 

  28. Vaiman, D., Mercier, D.L., Moazami-Goudarzi, K., et al., A set of 99 cattle microsatellites: characterisation, synteny mapping, and polymorphism, Mamm. Genome, 1994, vol. 5, no. 5, p. 288–297.

    Article  CAS  PubMed  Google Scholar 

  29. Vaiman, D., Osta, R., Mercier, D., et al., Characterization of five new bovine microsatellite repeats, Anim. Genet., 1992, vol. 23, no. 6, pp. 537–541.

    Article  CAS  PubMed  Google Scholar 

  30. Barendse, W., Armitage, S.M., Kossarek, L.M., et al., A genetic linkage map of the bovine genome, Nat. Genet., 1994, vol. 6, no. 3, pp. 227–235.

    Article  CAS  PubMed  Google Scholar 

  31. Brezinsky, L.S., Kemp, J., and Teale, A.J., ILSTS006: a polymorphic bovine microsatellite, Anim. Genet., 1993b, vol. 24, no. 1, p. 73.

    Google Scholar 

  32. Georges, M. and Massey, J.M., Polymorphic DNA markers in Bovidae, Patent WO 92/13102, 1992.

    Google Scholar 

  33. Thieven, U., Solinos-Toldo, S., Friedl, R., et al., Polymorphic CA-microsatellites for the integration of the bovine genetic and physical map, Mamm. Genome, 1997, vol. 8, no. 1, pp. 52–55.

    Article  CAS  PubMed  Google Scholar 

  34. Moore, S.S. and Byrne, K., Characterisation of 65 bovine microsatellites, Mamm. Genome, 1994, vol. 5, no. 2, pp. 84–90.

    Article  CAS  PubMed  Google Scholar 

  35. Mommens, G.W., Coppieters, A., van de Weghe, A., et al., Dinucleotide repeat polymorphism at the bovine MM12E6 and MM8D3 loci, Anim. Genet., 1994, vol. 25, no. 5, p. 368.

    Article  CAS  PubMed  Google Scholar 

  36. Moore, S.S. and Byrne, K., Dinucleotide polymorphism at the bovine calmodulin independent adenylcyclase locus, Anim. Genet., 1993, vol. 24, no. 2, p. 150.

    Google Scholar 

  37. Ivanov, P.L, Zemskova, E.Yu., Turakulov, R., and Efremov, I.A., Study of potentially linked variants of the chromosomal DNA polymorphism in relation to forensic application of molecular-genetic individualizing systems CD4, vWA, and WFII, Sud.-Med. Ekspert., 2005, no. 2, pp. 29–34.

    Google Scholar 

  38. McKay, S.D., Schnabel, R.D., Murdoch, B.M., et al., Whole genome linkage disequilibrium maps in cattle, BMC Genet., 2007, vol. 8, no. 74, pp. 1–12.

    Google Scholar 

  39. Kiseleva, T.Yu., Podoba, B.E., Zabludovskii, E.E., et al., Analysis of 30 microsatellite markers in six cattle populations, S-kh. Biol., 2010, no. 6, pp. 20–25.

    Google Scholar 

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Correspondence to T. Yu. Kiselyova.

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Original Russian Text © T.Yu. Kiselyova, J. Kantanen, N.I. Vorobyov, B.E. Podoba, V.P. Terletsky, 2014, published in Genetika, 2014, Vol. 50, No. 4, pp. 464–473.

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Kiselyova, T.Y., Kantanen, J., Vorobyov, N.I. et al. Linkage disequilibrium analysis for microsatellite loci in six cattle breeds. Russ J Genet 50, 406–414 (2014). https://doi.org/10.1134/S1022795414040048

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