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Aggregation effects in solutions of model oligopeptides and other amphiphilic polymers

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Abstract

The problems of the aggregation behavior of amphiphilic macromolecules in solution are discussed. The cases of electrically neutral and polyelectrolyte chains are examined. The effect of chain parameters, interaction parameters, and external factors—temperature, solvent quality, medium pH, and solution ionic strength—on the structure and stability of the aggregates is analyzed. As examples, two systems are selected: (i) a solution of model oligopeptides with different chain architectures that contain hydrophobic alanine and negatively charged polar aspartic acid and (ii) a solution of HP copolymers in which hydrophobic (H) groups are located in the backbone and polar (P) side groups have a rigid bond to the backbone. The micelles formed by the oligopeptides are thermodynamically stabilized after the addition of a univalent salt; in addition, the effect heavily depends on the pH of a medium and the size of the added cations. For the second system, the regions of stability of aggregates of different geometries are determined and the corresponding phase diagram is constructed as a function of the surface tension and bending modulus of the surface of the aggregate. The problems related to the kinetics of coalescence of the aggregates are discussed.

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Authors and Affiliations

  1. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninskii pr. 29, Moscow, 119991, Russia

    A. V. Subbotin

  2. Institut Charles Sadron, 6 rue Boussingault, 67083, Strasbourg CEDEX, France

    A. N. Semenov

Authors
  1. A. V. Subbotin
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  2. A. N. Semenov
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Correspondence to A. V. Subbotin.

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Original Russian Text © A.V. Subbotin, A.N. Semenov, 2012, published in Vysokomolekulyarnye Soedineniya, Ser. C, 2012, Vol. 54, No. 7, pp. 1000–1012.

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Subbotin, A.V., Semenov, A.N. Aggregation effects in solutions of model oligopeptides and other amphiphilic polymers. Polym. Sci. Ser. C 54, 36–47 (2012). https://doi.org/10.1134/S1811238212030010

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