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Current Issues in Statistics and Models for Ecotoxicological Risk Assessment

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Abstract

A review is given on statistical and modelling issues in ecotoxicology. The issues discussed are:

1. How to estimate an (almost) no effect concentration chemicals in the laboratory.

2. Combining single-species acceptable effect levels to an acceptable effect level for a multi-species ecosystem.

3. The combined effect of exposure to several chemicals.

4. Bioavailability in the natural environment and food-web models.

Most current procedures in setting standards allow the environmental concentration to be above the acceptable effect concentration for a small fraction of the species. It is shown that a considerable part of the fraction of the affected species will suffer a severe effect.

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REFERENCES

  • Aldenberg, T. and W. Slob (1993).Confidence limits for hazardous concentrations based on the logistically distributed NOEC toxicity data. Ecotoxicology and Environmental Safety 25: 48–63.

    Google Scholar 

  • Aldenberg, T. and J. Jaworska (2000).Uncertainty of the hazardous concentration and fraction affected for normal species sensitivity distributions.Ecotoxicology and Environmental Safety 46:1–18.

    Google Scholar 

  • Cabana, G. and J.B. Rasmussen (1994).Modelling food chain structure and contaminant bioaccumulation using stable nitrogen isotopes.Nature 372:255–257.

    Google Scholar 

  • Cairns Jr., J.(1992).The threshold problem in ecotoxicology.Ecotoxicology 1:3–16.

    Google Scholar 

  • Campfens, J. and D. Mackay (1997).Fugacity-based model of PCB bioaccumulation in complex aquatic food webs.Environmental Science and Technology 31:577–583.

    Google Scholar 

  • Chapman, P. F., M. Crane, J.A. Wiles, F. Noppert and E.C. McIndoe (1995).Asking the right questions:ecotoxicology and statistics.In:Report of a workshop held at Royal Holloway University of London, Egham, Surrey, United Kingdom, SETAC Eds,32 p.

    Google Scholar 

  • Chapman, P.M., R.S. Caldwell and P.F. Chapman (1996).A warning:NOECs are inappropriate for regulatory use.Environmental and Toxicological Chemistry 15:77–79.

    Google Scholar 

  • Cuppen, J.G.M., P.J. van den Brink, H. van de Woude, N. Zwaardemaker and T.C.M Brock (1997).Sensitivity of macrophyte dominated freshwater microcosms to chronic levels of the herbicide linuron.II Community metabolism and invertebrates.Ecotoxicology and Environmental Safety 38:25–35.

    Google Scholar 

  • De March, B.G.E.(1987).Simple similar action and independent action-two similar models for the joint effects of toxicants applied as mixtures.Aquatic Toxicology 9:291–304.

    Google Scholar 

  • Di Toro, D.M., C.S. Zarba, D.J. Hansen, W.J. Berry, R.C. Schwartz, C.E. Cowan, S.P. Pavlou, H.E. Allen, N.A. Thomas and P.R. Paquin (1991).Technical basis for establishing sediment quality criteria for nonionic organic chemicals using equilibrium partitioning. Environmental Toxicology and Chemistry 10:1541–1583.

    Google Scholar 

  • Drescher, K. and W. Boedeker (1995).Assessment of the combined effects of substances-the relationship between concentration addition and independent action.Biometrics 51: 716–730.

    Google Scholar 

  • ECB (1996).Technical Guidance Document in Support of Commission Directive 93/67/EEC on risk Assessment for New Notified Substances and the Commission Regulation (EC)No. 1488/94 on Risk Assessment for Existing Substances,EC Catalogue Numbers CR-48-96-001,002,003,004-EN-C.Office for Official Publications of the European Community, 2 Rue Mercier,L-2965 Luxembourg.

  • Gerstl, Z.(1990).Estimation of organic chemical sorption by soils.Journal of Contaminant Hydrology 6:357–375.

    Google Scholar 

  • Groten, J.P., E.D. Schoen and V.J. Feron (1996)Use of factorial designs in combination toxicity studies. Food and Chemical Toxicology 34:1083–1089.

    Google Scholar 

  • Hart, A.(2001).Probabilistic risk assessment for pesticides in Europe:Implementation and Research Needs.Report on the European workshop on Probabilistic Risk Assessment for the Environmental Impacts of Plant Protection Products (EUPRA).Central Science Laboratory. Sand Hutton, UK.www.eupra.com

    Google Scholar 

  • Health Council (1991).Ecotoxicological extrapolation methods.The Netherlands Health Council Report 1991/03,The Hague,The Netherlands.

  • Health Council (1993).Secondary Poisoning.Toxic substances in the food chain (in Dutch). The Netherlands Health Council Report 1993/04,The Hague,The Netherlands.

  • Hoekstra, J.A. and P.H. van Ewijk (1993).Alternatives for the No-Observed-Effect Level. Environmental and Toxicological Chemistry 12:187–194.

    Google Scholar 

  • Huang, P.M.(1980).Adsorption processes in soil.In:Hutzinger, O.(Ed.),The handbook of environmental chemistry,Vol.2A:reactions and processes.Springer Verlag, Berlin.

    Google Scholar 

  • ISO (2003).Water quality–Guidance document on the statistical analysis of ecotoxicity data. ISO TC 147/SC 5N 0390 ISO/CD 20281,April 4,2003.

  • Jagoe, R.H. and M.C. Newman (1997).Bootstrap estimation of community NOEC values. Ecotoxicology 6:293–306.

    Google Scholar 

  • Karickhoff, S.W., D.S. Brown and T.A. Scott (1979).Sorption of hydrophobic pollutants on natural sediments Water research 13:241–248.

    Google Scholar 

  • Kooijman, S.A.L.M.(1987).A safety factor for LC50 values allowing for differences in sensitivity among species.Water Research 21:269–276.

    Google Scholar 

  • Kooijman, S.A.L.M.(2000).Dynamic Energy and Mass Budgets in Biological Systems. Cambridge University Press, Cambridge, UK.

    Google Scholar 

  • Kooijman, S.A.L.M. and J.J.M. Bedaux (1996).The analysis of aquatic toxicity data.VU University Press, Amsterdam.

    Google Scholar 

  • Könemann, H.(1981).Fish toxicity tests with mixtures of more than two chemicals:a proposal for a quantitative approach and experimental results.Toxicology 19:229–238.

    Google Scholar 

  • Lambert, S.M., P.E. Porter and H. Schlieferstein (1965).Movement and sorption of chemicals applied to the soil.Weeds 13:185–190.

    Google Scholar 

  • Loewe, S. and H. Muischnek (1926).Über Kombinationswirkungen.1.Mitteilung:Hilfsmittel der Fragestellung.Archiv für Experimentelle Pathologie und Pharmakologie 114:313–326.

    Google Scholar 

  • Morrison, H.A., F.A.P.C. Gobas, R. Lazar, D.M. Whittle and G.D. Haffner (1997). Development and verification of a benthic/pelagic food web bioaccumulation model for PCB congeners in Western Lake Erie.Environmental Science and Technology 31: 3267–3273.

    Google Scholar 

  • Narotsky, M.G., E.A. Weller, M.C. Vernon and R.J. Kavlock (1995).Nonadditive developmental toxicity in mixtures of trichloroethylene, di(2-ethylhexyl)phtalate,and heptachlor in a 5X5X5 design.Fundamental and Applied Toxicology 27:203–216.

    Google Scholar 

  • Newman, M.C., D.R. Ownby, L.C.A. Mézin, D.C. Powell, T.R.L. Christensen, S.B. Lerberg and B.A. Anderson (2000).Applying species sensitivity distributions in ecological risk assessment:assumptions of distribution type and sufficient number of species. Environmental Toxicology and Chemistry 19:508–515.

    Google Scholar 

  • OECD (1992).Report on the OECD workshop on effects assessment of chemicals in sediment. OECD Environment Monograph No.60.Paris, France.

  • Pack, S.(1993).A review of statistical data analysis and experimental design in OECD aquatic toxicity test guidelines.Shell Research Ltd, Sittingbourne Research Centre, Sittingbourne, Kent.

    Google Scholar 

  • Posthuma, L., G.W. Suter II and T.P. Traas (2002).Species Sensitivity Distributions in Ecotoxicology.CRC Press LLC, Boca Raton.

    Google Scholar 

  • Romijn, C.A.F.M., R. Luttik and J.H. Canton (1994).Presentation of a general algorithm to include effect assessment on secondary poisoning in the derivation of environmental quality criteria.2.Terrestrial food chains.Ecotoxicology and Environmental Safety 27:107–127.

    Google Scholar 

  • Romijn, C.A.F.M., R. Luttik, D. van de Meent, W. Slooff and J.H. Canton (1993).Presentation of a general algorithm to include effect assessment on secondary poisoning in the derivation of environmental quality criteria.2.Aquatic food chains.Ecotoxicology and Environmental Safety 26:61–85.

    Google Scholar 

  • Russell, R.W., F.A.P.C. Gobas and G.D. Haffner (1999).Maternal transfer and in ovo exposure of organochlorines in oviparous organisms.A model and field verification.Environmental Science and Technology 33:416–420.

    Google Scholar 

  • Sabljic, A., H. Gusten, H. Verhaar and J. Hermens (1995).QSAR modeling of soil sorption. Improvements and systematics of log KOC vs. log KOW correlations.Chemosphere 31: 4489–4514.

    Google Scholar 

  • Sharpe, S. and D. Mackay (2000).A framework for evaluating bioaccumulation in food webs. Environmental Science and Technology 34:2373–2379.

    Google Scholar 

  • Shaw, J.L. and P.J. Manning (1996).Evaluating macroinvertebrate population and community level effects in outdoor microcosms:use of in situ bioassays and multivariate analysis. Environmental Toxicology and Chemistry 15:508–617.

    Google Scholar 

  • Sijm, D.T.H.M. and A. van der Linde (1995).Size-dependent bioconcentration kinetics of hydrophobic organic chemicals in fish based on diffusive mass transfer and allometric relationships.Environmental Science and Technology 29:2769–2777.

    Google Scholar 

  • Slooff, W., J.A.M. van Oers and D. de Zwart (1986).Margins of uncertainty in ecotoxicological hazard assessment.Environmental Toxicology and Chemistry 5:841–852.

    Google Scholar 

  • Sprague, J.B.(1970).Measurement of pollutant toxicity to fish.II Utilizing and applying bioassay results.Water Research 4:3–32.

    Google Scholar 

  • Starodub, M.E., P.A. Miller, G.M. Ferguson, J.P. Giesy and R.E. Willes (1996).A risk-based protocol to develop acceptable concentrations of bioaccumulative organic chemicals in sediment for the protection of piscivorous wildlife.Toxicology and Environmental Chemistry 54:243–259.

    Google Scholar 

  • Stumm, W.(1987).Aquatic surface chemistry:chemical processes at the particle-water interface. J.Wiley and Sons, New York.

    Google Scholar 

  • Traas, T.P., J.A. Stäb, P.R.G. Kramer, W.P. Cofino and T. Aldenberg (1996a).Modeling and risk assessment of tributyltin accumulation in the food web of a shallow freshwater lake. Environmental Science and Technology 30:1227–1237.

    Google Scholar 

  • Traas, T.P., R. Luttik and R.H. Jongbloed (1996b).A probabilistic model for deriving soil quality criteria based on secondary poisoning of top predators.Ecotoxicology and Environmental Safety 34:264–278.

    Google Scholar 

  • Traas, T.P., J.H. Janse, T. Aldenberg and T.C.M. Brock (1998).A food web model for fate, direct and indirect effects of chlorpyrifos in freshwater microcosms.Aquatic Ecology 32: 179–190.

    Google Scholar 

  • Traas, T.P., A.P. van Wezel, J.L.M. Hermens, M. Zorn, A.G.M. van Hattum and C.J. van Leeuwen (in press).Prediction of environmental quality criteria for organic chemicals from internal effect concentrations and a food web model.Environmental Toxicology and Chemistry (in press).

  • van de Meent, D., T. Aldenberg, J.H. Canton, C.A.M. van Gestel and W. Slooff (1990).Desire for levels.Background study for the policy document "setting environmental quality standards for water and soil’.Report 670101 002,RIVM,Bilthoven.

  • Van den Berg M., L. Birnbaum, A.T.C. Bosveld, B. Brunström, P. Cook, M. Feeley, J.P. Giesy, A. Hanberg, R. Hasegawa, S.W. Kennedy, T. Kubiak, J.C. Laren, F.X.R. van Leeuwen, A.K. Djien Liem, C. Nolt, R.E. Peterson, L. Poellinger, S. Safe, D. Schrenk, D. Tillitt, M. Tysklind, M. Younes, F. Wærn and T. Zacharewski (1998).Toxic equivalency factors (TEFs)for PCBs,PCDDs,PCDFs for humans and wildlife.Environmental Health Perspective 106:775–92.

    Google Scholar 

  • Van den Brink, P.J.(1999).Ecological and statistical evaluation of effects of pesticides in freshwater model ecosystems.PhD Thesis Landbouwuniversiteit Wageningen, Wageningen, The Netherlands.

    Google Scholar 

  • Van den Brink, P.J., R.P.A. van Wijngaarden, W.G.H. Lucassen, T.C.M. Brock and P. Leeuwangh (1996).Effects of the insecticide Dursban ® 4 E (active ingredient chlorpyrifos)in outdoor experimental ditches.II.Invertebrate community response and recovery.Environmental Toxicology and Chemistry 15:1143–1153.

    Google Scholar 

  • Van den Brink, P.J., E.M. Hartgers, U. Fettweis, S.J.H. Crum, E. van Donk and T.C.M. Brock (1997).Sensitivity of macrophyte dominated freshwater microcosms to chronic levels of the herbicide linuron.I.Primary producers.Ecotoxicology and Environmental Safety 38:13–24.

    Google Scholar 

  • van der Hoeven, N.(1997).How to measure no effect,part III:Statistical aspects of NOEC and ECx estimates.Environmetrics 8:255–261.

    Google Scholar 

  • van der Hoeven, N.(2001).Estimating the 5-percentile of the species sensitivity distributions without any assumptions about the distribution.Ecotoxicology 10:25–34.

    Google Scholar 

  • van der Hoeven, N., F. Noppert and A. Leopold (1994).How to measure no effect? Towards a new measure of chronic toxicity in ecotoxicology? Report of workshop “How to measure no effect”,The Hague,September 9th,1994.

  • van der Hoeven, N., F. Noppert and A. Leopold (1997).How to measure no effect,part I: Towards a new measure of chronic toxicity in ecotoxicology.Introduction and workshop results.Environmetrics 8:241–248.

    Google Scholar 

  • van Straalen, N.M.(1997).How to measure no effect,part II:Threshold effects in ecotoxicology.Environmetrics 8:249–253.

    Google Scholar 

  • van Straalen, N.M. and C.A.J. Denneman (1989).Ecotoxicological Evaluation of Soil Quality Criteria.Ecotoxicology and Environmental Safety 18:241–251.

    Google Scholar 

  • van Wezel, A.P., T.P. Traas, M.E.J. van der Weiden, T.H. Crommentuijn and D.T.H.M. Sijm (2000).Environmental risk limits for polychlorinated biphenyls in the Netherlands: derivation with probabilistic food chain modeling.Environmental Toxicology and Chemistry19:2140–2153.

    Google Scholar 

  • Wagner, C. and H. Løkke (1991).Estimation of ecotoxicological protection levels for NOEC toxicity data.Water Research 25:1237–1242.

    Google Scholar 

  • Walker, C.H.(1990).Essay review, Kinetic models to predict bioaccumulation of pollutants. Functional Ecology 4:295–301.

    Google Scholar 

  • Warne, M.S.J. and D.W. Hawker (1995).The number of components in a mixture determines whether synergistic and antagonistic or additive toxicity predominates: the funnel hypothesis.Ecotoxicology and Environmental Safety 31:23–28.

    Google Scholar 

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van der Hoeven, N. Current Issues in Statistics and Models for Ecotoxicological Risk Assessment. Acta Biotheor 52, 201–217 (2004). https://doi.org/10.1023/B:ACBI.0000043442.05899.8c

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