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Molecular Properties and Physiological Roles of Ion Channels in the Immune System

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Abstract

The discovery of a diverse and unique set of ion channels in T lymphocytes has led to a rapidly growing body of knowledge about their functional roles in the immune system. Here we review the biophysical and molecular characterization of K+, Ca2+, and Cl− channels in T lymphocytes. Potent and specific blockers, especially of K+ channels, have provided molecular tools to elucidate the involvement of voltage- and calcium-activated potassium channels in T-cell activation and cell-volume regulation. Their unique and differential expression makes lymphocyte K+ channels excellent pharmaceutical targets for modulating immune system function. This review surveys recent progress at the biophysical, molecular, and functional roles of the ion channels found in T lymphocytes.

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  1. Department of Physiology and Biophysics, University of California, Irvine, Irvine, California, 92697

    Michael D. Cahalan, Heike Wulff & K. George Chandy

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Cahalan, M.D., Wulff, H. & Chandy, K.G. Molecular Properties and Physiological Roles of Ion Channels in the Immune System. J Clin Immunol 21, 235–252 (2001). https://doi.org/10.1023/A:1010958907271

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