Abstract
This study simulates the effect of stenting in an image-based coronary model. Three-dimensional models of the coronary artery were created from computed tomography images of a coronary artery stenosis patient before and after stent implantation, and a realistic aorto-coronary differential pressure was imposed at the inlet of the computational vessels. The results show that the stent increased the flow rate several fold compared to that for the stenosis artery model, and that the hemodynamic values returned to near normal levels in the coronary artery model fitted with a stent. The results confirm that stenting significantly improves the hemodynamics of the artery.
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Davies, P., Shi, C., DePaola, N., Helmke, B., & Polacek, D. (2001). Hemodynamics and the focal origin of atherosclerosis. A spatial approach to endothelial structure, gene expression, and function. Annals of the New York Academy of Sciences, 947, 7–16.
Vernhet, H., Demaria, R., Oliva-Lauraire, M. C., Juan, J., Senac, J. P., & Dauzat, M. (2001). Changes in wall mechanics after endovascular stenting in rabbit aorta: comparison of three diffierent stent designs. American Journal of Roentgenology, 176, 803–807.
Vernhet, H., Juan, J. M., Demaria, R., Oliva-Lauraire, M. C., Senac, J. P., & Dauzat, M. (2000). Acute changes in aortic wall mechanical properties after stent placement in rabbits. Journal of Vascular and Interventional Radiology, 11, 634–638.
Rolland, P. H., Charifi, A. B., & Verrier, C. (1999). Hemodynamics and wall mechanics after stent placement in swine illiac arteries: Comparative results from six stent designs. Radiology, 213, 229–246.
Torii, R., Oshima, M., Kobayashi, T., Takagi, K., & Tezduyar, T. E. (2007). Influence of wall elasticity in patient-specific hemodynamic simulations. Computers & Fluids, 36, 160–168.
Takizawa, K., Schjodt, K., Puntel, A., Kostov, N., & Tezduyar, T. E. (2012). Patient-specific computer modeling of blood flow in cerebral arteries with aneurysm and stent. Computational Mechanics, 50, 675–686.
Fu, W., Gu, Z., Meng, X., Chu, B., & Qiao, A. (2010). Numerical simulation of hemodynamics in stented internal carotid aneurysm based on patient-specific model. Journal of Biomechanics, 43, 1337–1342.
Attili, A. K., & Cascade, P. N. (2006). CT and MRI of coronary artery disease: evidence-based review. AJR. American Journal of Roentgenology, 187, S483–S499.
Ene-Iordache, B., Mosconi, L., Remuzzi, G., & Remuzzi, A. (2001). Computational fluid dynamics of a vascular access case for hemodyalsis. Journal of Biomechanical Engineering, 123, 284–292.
van Langenhove, G., Wentzel, J. J., Krams, R., Slager, C. J., Hamburger, J. N., & Serruys, P. W. (2000). Helical velocity patterns in a human coronary artery. A three-dimensional computational fluid dynamic reconstruction showing the relation with local wall thickness. Circulation, 102, e22–e24.
Perktold, K., Hofer, M., Rappitsch, G., Loew, M., Kuban, B. D., & Friedman, M. H. (1998). Validated computation of physiologic flow in a realistic coronary artery branch. Journal of Biomechanics, 31, 217–228.
Steinman, D. A. (2002). Image-based CFD modeling in realistic arterial geometries. Annals of Biomedical Engineering, 30, 483–497.
Holzapfel, G., Stadler, M., & Schulze-Bauer, C. (2002). A layer-specific three-dimensional model for the simulation of balloon angioplasty using magnetic resonance imaging and mechanical testing. Annals of Biomedical Engineering, 30, 753–767.
Kiousis, D., Gasser, T., & Holzapfel, G. (2007). A numerical model to study the interaction of vascular stents with human atherosclerotic lesions. Annals of Biomedical Engineering, 35, 1857–1869.
Gijsen, F., Migliavacca, F., & Schievano, S. (2008). Simulation of stent deployment in a realistic human coronary artery. Biomedical Engineering Online, 7, 23.
Berger, S. A., Goldsmith, W., & Lewis, E. R. (1996). Introduction to bioengineering. New York: Oxford University Press.
Gould, K. L. (1978). Pressure-flow characteristics of coronary stenoses in unsedated dogs at rest and during coronary vasodilation. Circulation Research, 43, 242–253.
Gould, K. L., Lipscomb, K., & Hamilton, G. W. (1974). Physiologic basis for assessing critical coronary stenosis. Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve. American Journal of Cardiology, 33, 87–94.
Piek, J. J., Boersma, E., & di Mario, C. (2000). Angiographical and Doppler flow-derived parameters for assessment of coronary lesion severity and its relation to the result of exercise electrocardiography. DEBATE study group. Doppler Endpoints Balloon Angioplasty Trial Europe. European Heart Journal, 21, 466–474.
Ku, D. N., Giddens, D. P., Zarins, C. K., & Glagov, S. (1985). Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress. Arteriosclerosis, 5, 293–302.
Botnar, R., Rappitsch, G., Scheidegger, M. B., Liepsch, D., Perktold, K., & Boesiger, P. (2000). Hemodynamics in the carotid artery bifurcation: a comparison between numerical simulations and in vitro MRI measurements. Journal of Biomechanics, 33, 137–144.
Ethier, C. R., Steinman, D. A., Zhang, X., Karpik, S. R., & Ojha, M. (1998). Flow waveform effects on end-to-side anastomotic flow patterns. Journal of Biomechanics, 31, 609–617.
Hughes, P. E., & How, T. V. (1995). Flow structures at the proximal side-to-end anastomosis. Influence of geometry and flow division. Journal of Biomechanical Engineering, 117, 224–236.
Hyun, S., Kleinstreuer, C., & Archie, J. P. (2000). Hemodynamics analyses of arterial expansions with implications to thrombosis and restenosis. Medical Engineering & Physics, 22, 13–27.
Zhao, S. Z., Xu, X. Y., Hughes, A. D., Thom, S. A., Stanton, A. V., Ariff, B., & Long, Q. (2000). Blood flow and vessel mechanics in a physiologically realistic model of a human carotid arterial bifurcation. Journal of Biomechanics, 33, 975–984.
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Li, G., Hu, R. & Gao, F. Numerical Simulation of Coronary Artery Stenosis Before and After Stenting. J. Med. Biol. Eng. 35, 528–534 (2015). https://doi.org/10.1007/s40846-015-0058-z
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DOI: https://doi.org/10.1007/s40846-015-0058-z