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The correlation of resistance exercise-induced myostatin with insulin resistance and plasma cytokines in healthy young men

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Abstract

Purpose

This study was designed to examine the correlation of resistance exercise (RE)-induced myostatin (MSTN) with insulin resistance and plasma cytokines in healthy young men.

Methods

Twenty-four healthy men were randomly divided into RE (n = 12) and control (n = 12) group. After a session of familiarization, one repetition maximum (1-RM) was calculated. Circuit RE program involved 3 sets of 15 repetitions at 55 % of 1-RM. Blood samples were collected before and 24 h after the exercise. Paired t test, independent t test, and Pearson’s correlation were used for analyzing data.

Results

A significant decrease in plasma level of MSTN, glucose, insulin, interleukin-6 (IL-6), and homeostasis model assessment of insulin resistance (HOMA-IR) and a significant increase in plasma interleukin-10 (IL-10) were found in RE group 24 h post-exercise versus pre-exercise (p < 0.05). Furthermore, except plasma IL-10, a significant decrease in metabolic variables was found in RE group versus control group (p < 0.05). A significantly positive correlation of plasma MSTN with HOMA-IR and plasma IL-6 and a significantly negative correlation of plasma MSTN with plasma IL-10 were found in RE group versus control group (p < 0.05).

Conclusions

It seems that a circuit RE bout by reducing HOMA-IR and changing plasma cytokines (decreased IL-6 and increased IL-10) can decrease plasma level of MSTN in healthy young men. In other word, the beneficial effect of acute RE may be reflected by changes in MSTN in healthy young individuals.

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Acknowledgments

The author thanks all the subjects for their participation in this study.

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Authors and Affiliations

  1. School of Physical Education and Sport Sciences, Shahid Beheshti University, Tehran, Iran

    F. Kazemi

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  1. F. Kazemi
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Correspondence to F. Kazemi.

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Author has no conflict of interests.

Ethical approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the Ethics Committee of the Shahid Beheshti University, Faculty of Physical Education and Sport Sciences.

Informed consent

Informed consent was obtained from all individual participants included in this study.

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Cite this article

Kazemi, F. The correlation of resistance exercise-induced myostatin with insulin resistance and plasma cytokines in healthy young men. J Endocrinol Invest 39, 383–388 (2016). https://doi.org/10.1007/s40618-015-0373-9

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  • DOI: https://doi.org/10.1007/s40618-015-0373-9

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