Abstract
Parkinson’s disease (PD) is a multisystem disorder, and besides the classical motor symptoms it is now known that patients also suffer from a variety of non-motor symptoms that adversely affect quality of life (QOL). Since data on Hispanic populations on this issue are scarce, our aim was to study the association of non-motor symptoms and QOL in patients with PD. This study is a cross-sectional observational study involving patients with PD using the following instruments: Quality of Life Questionnaire (PDQ-8), Unified Parkinson’s Disease Rating Scale part III (UPDRS part III), and Non-Motor Symptom Scale (NMSS). We included 52 patients, with a median age of 64 years. Sleep/fatigue and mood/cognitive domains were the most common non-motor symptoms. Only sleep/fatigue, mood/cognition and gastrointestinal domains were associated with worse PDQ-8 scores. After adjusting for confounding variables, NMSS scores were significantly associated with a high PDQ-8 score. Higher NMSS scores were associated with and predicted higher PDQ-8 scores. The focus of management in PD should shift to a comprehensive strategy that incorporates care of non-motor symptoms and improves QOL.
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References
Chaudhuri KR, Odin P, Antonini A, Martinez-Martin P (2011) Parkinson’s disease: the non-motor issues. Parkinsonism Relat Disord 17:717–723
Uitti RJ (2012) Treatment of Parkinson’s disease: focus on quality of life issues. Parkinsonism Relat Disord 18(Suppl 1):S34–S36
Martinez-Martin P (2011) The importance of non-motor disturbances to quality of life in Parkinson’s disease. J Neurol Sci 310:12–16
Lee CN, Kim M, Lee HM et al (2013) The interrelationship between non-motor symptoms in Atypical Parkinsonism. J Neurol Sci 327:15–21
Li H, Zhang M, Chen L et al (2010) Nonmotor symptoms are independently associated with impaired health-related quality of life in Chinese patients with Parkinson’s disease. Mov Disord 25:2740–2746
Chaudhuri KR, Martinez-Martin P, Brown RG et al (2007) The metric properties of a novel non-motor symptoms scale for Parkinson’s disease: results from an international pilot study. Mov Disord 22:1901–1911
Martinez-Martin P, Rodriguez-Blazquez C, Abe K et al (2009) International study on the psychometric attributes of the non-motor symptoms scale in Parkinson disease. Neurology 73:1584–1591
Jenkinson C, Fitzpatrick R, Peto V, Greenhall R, Hyman N (1997) The PDQ-8: development and validation of a short-form. Parkinson’s disease questionnaire. Psychol Health. 12:805–814
Movement Disorder Society Task Force on Rating Scales for Parkinson’s Disease (2003) The Unified Parkinson’s Disease Rating Scale (UPDRS): status and recommendations. Mov Disord 18:738–750
Breen KC, Drutyte G (2013) Non-motor symptoms of Parkinson’s disease: the patient’s perspective. J Neural Transm 120:531–535
Barone P, Antonini A, Colosimo C et al (2009) The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord 24:1641–1649
Khoo TK, Yarnall AJ, Duncan GW et al (2013) The spectrum of nonmotor symptoms in early Parkinson disease. Neurology 80:276–281
Weerkamp NJ, Tissingh G, Poels PJ et al (2013) Nonmotor symptoms in nursing home residents with Parkinson’s disease: prevalence and effect on quality of life. J Am Geriatr Soc 61:1714–1721
Song Y, Gu Z, An J, Chan P, Chinese Parkinson Study Group (2014) Gender differences on motor and non-motor symptoms of de novo patients with early Parkinson’s disease. Neurol Sci 35:1991–1996
Rodríguez-Violante M, Cervantes-Arriaga A, Villar-Velarde A, Corona T (2010) Prevalence of non-motor dysfunction among Parkinson’s disease patients from a tertiary referral center in Mexico City. Clin Neurol Neurosurg 112:883–885
Rodríguez-Violante M, Cervantes-Arriaga A, Corona T et al (2013) Clinical determinants of health-related quality of life in Mexican patients with Parkinson’s disease. Arch Med Res 44:110–114
Duncan GW, Khoo TK, Yarnall AJ et al (2013) Health-related quality of life in early Parkinson’s disease: the impact of nonmotor symptoms. Mov Disord 29:195–202
Gallagher DA, Lees AJ, Schrag A (2010) What are the most important nonmotor symptoms in patients with Parkinson’s disease and are we missing them? Mov Disord 25:2493–2500
Weintraub D, Moberg PJ, Duda JE, Katz IR, Stern MB (2004) Effect of psychiatric and other nonmotor symptoms on disability in Parkinson’s disease. J Am Geriatr Soc 52:784–788
Santos-García D, de la Fuente-Fernández R (2013) Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson’s disease. J Neurol Sci 332:136–140
Chen JJ, Marsh L (2013) Depression in Parkinson’s disease: identification and management. Pharmacotherapy 33:972–983
Salat-Foix D, Suchowersky O (2012) The management of gastrointestinal symptoms in Parkinson’s disease. Expert Rev Neurother 12:239–248
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Estrada-Bellmann, I., Camara-Lemarroy, C.R., Calderon-Hernandez, H.J. et al. Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico. Acta Neurol Belg 116, 157–161 (2016). https://doi.org/10.1007/s13760-015-0544-7
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DOI: https://doi.org/10.1007/s13760-015-0544-7