Skip to main content
SpringerLink
Log in

Cytokine dynamics in a 14-year-old girl with tubulointerstitial nephritis and uveitis syndrome

  • Case Report
  • Published:
CEN Case Reports Aims and scope Submit manuscript

Abstract

Tubulointerstitial nephritis and uveitis (TINU) syndrome, which was first described in 1975, has been reported in more than 130 patients, mostly in adolescent or young women. Although data concerning the etiologic background of this inflammatory disease are limited, several humoral factors, including cytokines, have been reported in association with the disease. Here, we report a case of TINU in a 14-year-old girl, whose renal and ophthalmological improvement was associated with the decrease of serum levels of tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), and interleukin-8 (IL-8). This suggests the presence of T-cell-mediated immunity in this unique syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Dobrin RS, Vernier RL, Fish AL. Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome. Am J Med. 1975;59:325–33.

    Article  CAS  PubMed  Google Scholar 

  2. Vohra S, Eddy A, Levin AV, Taylor G, Laxer RM. Tubulointerstitial nephritis and uveitis in children and adolescents. Four new cases and a review of the literature. Pediatr Nephrol. 1999;13:426–32.

    Article  CAS  PubMed  Google Scholar 

  3. Van Acker KJ, Buyssens N, Neetens A, Lequesne M, Desmet N. Acute tubulo-interstitial nephritis with uveitis. Acta Paediatr Belg. 1980;33:171–7.

    PubMed  Google Scholar 

  4. Birnbacher R, Balzar E, Aufricht C, Schmaldienst S, Woloszczuk W, Förster E. Tubulointerstitial nephritis and uveitis: an immunological disorder? Pediatr Nephrol. 1995;9:193–5.

    Article  CAS  PubMed  Google Scholar 

  5. Kase S, Kitaichi N, Namba K, Miyazaki A, Yoshida K, Ishikura K, Ikeda M, Nakashima T, Ohno S. Elevation of serum Krebs von den Lunge-6 levels in patients with tubulointerstitial nephritis and uveitis syndrome. Am J Kidney Dis. 2006;48:935–41.

    Article  CAS  PubMed  Google Scholar 

  6. Tanaka H, Suzuki K, Nakahata T, Tateyama T, Waga S, Ito E. Repeat renal biopsy in a girl with tubulointerstitial nephritis and uveitis syndrome. Pediatr Nephrol. 2001;16:885–7.

    Article  CAS  PubMed  Google Scholar 

  7. Ozdemir C, Akdis M, Akdis CA. T-cell response to allergens. Chem Immunol Allergy. 2010;95:22–44.

    Article  CAS  PubMed  Google Scholar 

  8. Schmouder RL, Strieter RM, Wiggins RC, Chensue SW, Kunkel SL. In vitro and in vivo interleukin-8 production in human renal cortical epithelia. Kidney Int. 1992;41:191–8.

    Article  CAS  PubMed  Google Scholar 

  9. Strieter RM, Koch AE, Antony VB, Fick RB Jr, Standiford TJ, Kunkel SL. The immunopathology of chemotactic cytokines: the role of interleukin-8 and monocyte chemoattractant protein-1. J Lab Clin Med. 1994;123:183–97.

    CAS  PubMed  Google Scholar 

  10. Kuroiwa T, Schlimgen R, Illei GG, McInnes IB, Boumpas DT. Distinct T cell/renal tubular epithelial cell interactions define differential chemokine production: implications for tubulointerstitial injury in chronic glomerulonephritides. J Immunol. 2000;164:3323–9.

    Article  CAS  PubMed  Google Scholar 

  11. Takase H, Futagami Y, Yoshida T, Kamoi K, Sugita S, Imai Y, Mochizuki M. Cytokine profile in aqueous humor and sera of patients with infectious or noninfectious uveitis. Invest Ophthalmol Vis Sci. 2006;47:1557–61.

    Article  PubMed  Google Scholar 

  12. Torii K, Kimura H, Li X, Okada T, Imura T, Furusaki F, Ono T, Yoshida H. Effects of hypoxia and tumor necrosis factor-α on production of plasminogen activator inhibitor-1 in human proximal renal tubular cells. Rinsho Byori. 2005;53:207–12.

    CAS  PubMed  Google Scholar 

  13. Eddy AA. Plasminogen activator inhibitor-1 and the kidney. Am J Physiol Renal Physiol. 2002;283:F209–20.

    CAS  PubMed  Google Scholar 

  14. Rerolle JP, Hertig A, Nguyen G, Sraer JD, Rondeau EP. Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis. Kidney Int. 2000;58:1841–50.

    Article  CAS  PubMed  Google Scholar 

  15. Kodner CM, Kudrimoti A. Diagnosis and management of acute interstitial nephritis. Am Fam Physician. 2003;67:2527–34.

    PubMed  Google Scholar 

  16. Gerritsma JS, Hiemstra PS, Gerritsen AF, Prodjosudjadi W, Verweij CL, Van Es LA, Daha MR. Regulation and production of IL-8 by human proximal tubular epithelial cells in vitro. Clin Exp Immunol. 1996;103:289–94.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Garin EH, West L, Zheng W. Effect of interleukin-8 on glomerular sulfated compounds and albuminuria. Pediatr Nephrol. 1997;11:274–9.

    Article  CAS  PubMed  Google Scholar 

  18. Kanai T, Yamagata T, Momoi MY. Macrophage inflammatory protein-1β and interleukin-8 associated with idiopathic steroid-sensitive nephrotic syndrome. Pediatr Int. 2009;51:443–7.

    Article  CAS  PubMed  Google Scholar 

  19. Tang S, Leung JC, Tsang AW, Lan HY, Chan TM, Lai KN. Transferrin up-regulates chemokine synthesis by human proximal tubular epithelial cells: implication on mechanism of tubuloglomerular communication in glomerulopathic proteinura. Kidney Int. 2002;61:1655–65.

    Article  CAS  PubMed  Google Scholar 

  20. Takemura T, Okada M, Hino S, Fukushima K, Yamamoto S, Miyazato H, Maruyama K, Yoshioka K. Course and outcome of tubulointerstitial nephritis and uveitis syndrome. Am J Kidney Dis. 1999;34:1016–21.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

The authors have declared no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan

    Jun Aoyagi, Takahiro Kanai, Takane Ito, Jun Odaka, Takashi Saito & Mariko Y. Momoi

Authors
  1. Jun Aoyagi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takahiro Kanai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takane Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jun Odaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takashi Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mariko Y. Momoi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Jun Aoyagi or Takahiro Kanai.

About this article

Cite this article

Aoyagi, J., Kanai, T., Ito, T. et al. Cytokine dynamics in a 14-year-old girl with tubulointerstitial nephritis and uveitis syndrome. CEN Case Rep 3, 49–52 (2014). https://doi.org/10.1007/s13730-013-0084-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13730-013-0084-z

Keywords

Search

Navigation