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Associated factors of different combined albuminuria and estimated glomerular filtration rate stages among patients with type 2 diabetes mellitus

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Abstract

Albuminuria and reduced glomerular filtration rate have a great impact on the progression of end-stage renal disease and cardiovascular events. The purpose of the study was to determine the clinical factors associated with different combined albuminuria and glomerular filtration rate among patients with type 2 diabetes. A total of 361 consecutive outpatients who attended the department of endocrinology and metabolism were retrospectively recruited in this cross-sectional study. Urinary albuminuria-creatinine ratio and estimated glomerular filtration rate were applied to designate different renal stages. Polytomous logistic regression was then performed to assess the associated clinical factors among these different renal stages. The proportion of subjects with normoalbuminuria with low glomerular filtration rate was 8.3 % in all study patients. We demonstrated that associated factors of different combined albuminuria and estimated glomerular filtration rate stages were quite distinct, and correlate factors for normoalbuminuria with low glomerular filtration rate were older age (p < 0.001), longer duration of diabetes (p = 0.009), and more statin/fibrate use (odd ratio [95 % confidence interval]: 4.37 [1.45–13.18]; p = 0.009). The associated factors among different combined albuminuria and estimated glomerular filtration rate stages were distinct. Whether early modification of these related factors can prevent or delay the progression of kidney disease warrants further investigations.

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Authors and Affiliations

  1. Division of Nephrology, Department of Internal Medicine, Yuan’s General Hospital, Kaohsiung, Taiwan, Republic of China

    Yit-Sheung Yap

  2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Yuan’s General Hospital, No. 162, Chenggong 1st Rd., LingYa District, Kaohsiung City, 802, Taiwan, Republic of China

    Chih-Ming Chien & Yen-Kuang Tai

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  1. Yit-Sheung Yap
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  2. Chih-Ming Chien
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Correspondence to Yen-Kuang Tai.

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Yap, YS., Chien, CM. & Tai, YK. Associated factors of different combined albuminuria and estimated glomerular filtration rate stages among patients with type 2 diabetes mellitus. Int J Diabetes Dev Ctries 35 (Suppl 3), 362–368 (2015). https://doi.org/10.1007/s13410-015-0324-1

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  • DOI: https://doi.org/10.1007/s13410-015-0324-1

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