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Comparative analysis of basaloid and conventional squamous cell carcinomas of the esophagus: prognostic relevance of clinicopathological features and protein expression

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Tumor Biology

Abstract

Basaloid squamous cell carcinoma (BSCC), a variant of squamous cell carcinoma (SCC), is a rare and aggressive epithelial malignancy which has been reported in only 0.1–11 % of primary esophageal carcinomas. In this study, a comparison of clinicopathological features and protein expression between esophageal BSCC (EBSCC) and conventional esophageal SCC (ESCC) cases from Brazil was performed in order to find factors that can be relevant to better characterize EBSCC. The expression of HER2, epidermal growth factor receptor (EGFR), Ki-67, and cyclins (A, B1, and D1) in 111 cases (95 ESCC and 16 EBSCC) was evaluated by immunohistochemistry using tissue microarray. When the clinicopathological data were compared, no significant difference was found between the two histological types. Although the difference is not significant (p = 0.055), the EGFR expression was more frequent in the conventional ESCC than in the EBSCC group. Our results indicate that the clinicopathological profiles of conventional ESCC and EBSCC are similar and provide no indicators for differences in prognosis between these two groups.

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Acknowledgments

The authors thank Carlos Ferreira Nascimento and Severino Ferreira da Silva for providing technical assistance. This study was supported by grants from the Fundação de Apoio a Pesquisa do Estado de São Paulo (FAPESP).

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Authors and Affiliations

  1. International Research Center, A.C. Camargo Cancer Center, Rua Taguá, 440 Liberdade, São Paulo, SP, 01508-010, Brazil

    Yukie Sato-Kuwabara & Juliano Jampietro

  2. Gynecologic Oncology Department, Fundação Pio XII, Hospital do Câncer de Barretos, Rua Antenor Duarte Villela, 1331, Barretos, SP, 14784-400, Brazil

    José Humberto T. G. Fregnani

  3. Obstetrics and Gynecology Department, Faculty of Medicine, University of São Paulo, Av. Dr. Arnaldo, 455, São Paulo, SP, 01246-903, Brazil

    Katia Cândido Carvalho

  4. Department of Abdominal Surgery, A.C. Camargo Cancer Center, Rua Antônio Prudente, 211, 1o. andar, São Paulo, SP, 01509-010, Brazil

    Carolina Parucce Franco, Wilson Luís da Costa Jr. & Felipe J. F. Coimbra

  5. Department of Anatomic Pathology, A.C. Camargo Cancer Center, Rua Antônio Prudente, 211, 1o. andar, São Paulo, SP, 01509-010, Brazil

    Fernando Augusto Soares

  6. Department of Stomatology, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil

    Fernando Augusto Soares

Authors
  1. Yukie Sato-Kuwabara
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  2. José Humberto T. G. Fregnani
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  3. Juliano Jampietro
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  4. Katia Cândido Carvalho
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  5. Carolina Parucce Franco
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  6. Wilson Luís da Costa Jr.
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  7. Felipe J. F. Coimbra
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  8. Fernando Augusto Soares
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Corresponding author

Correspondence to Yukie Sato-Kuwabara.

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Funding

This study was supported by grants from the Fundação de Apoio a Pesquisa do Estado de São Paulo (FAPESP 2010/19572-6).

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Sato-Kuwabara, Y., Fregnani, J.H.T.G., Jampietro, J. et al. Comparative analysis of basaloid and conventional squamous cell carcinomas of the esophagus: prognostic relevance of clinicopathological features and protein expression. Tumor Biol. 37, 6691–6699 (2016). https://doi.org/10.1007/s13277-015-4551-3

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  • DOI: https://doi.org/10.1007/s13277-015-4551-3

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