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The prognostic value of HER-2/neu overexpression in colorectal cancer: evidence from 16 studies

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Tumor Biology

Abstract

Human epidermal growth factor receptor (HER-2/neu) plays an important role in the progression of several types of cancer. Numerous studies examining the relationship between HER-2 overexpression and prognostic impact in patients with colorectal cancer have yielded inconclusive results. We therefore conducted a meta-analysis to provide a comprehensive evaluation of the prognostic value of HER-2 expression on the survival, which compared the positive and negative expressions of HER-2 in patients of the available studies. Hazard ratios (HRs) and their corresponding 95 % confidence intervals (95 % CIs) were pooled in terms of disease-specific or overall survival. A detailed search was made in PubMed for relevant original articles published in English. Finally, a total of 18 studies with 16 colorectal cancer patients were involved. Overexpression of HER-2 was negatively related to survival in colorectal cancer patients with the pooled HR of 1.05 (95 % CI 0.78–1.31, P = 0.000). In conclusion, the finding from this present meta-analysis suggested that HER-2 overexpression was not related to poor prognostic of colorectal cancer.

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Authors and Affiliations

  1. Department of General surgery, The Affiliated Jianhu Hospital of Nantong University, Jianhu People’s Hospital, Jianhu, 224700, Jiangsu Province, China

    Sheng-wen Wu, Cong-chao Ma & Yu Yang

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  1. Sheng-wen Wu
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  2. Cong-chao Ma
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  3. Yu Yang
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Correspondence to Cong-chao Ma.

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Wu, Sw., Ma, Cc. & Yang, Y. The prognostic value of HER-2/neu overexpression in colorectal cancer: evidence from 16 studies. Tumor Biol. 35, 10799–10804 (2014). https://doi.org/10.1007/s13277-014-2376-0

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  • DOI: https://doi.org/10.1007/s13277-014-2376-0

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