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Prognostic and Predictive Value of Tumor-Infiltrating Lymphocytes in Breast Cancer

  • Translational Research (T King and E Mittendorf, Section Editors)
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Abstract

Recent attention has focused on the antitumor immune response in breast cancer, in particular, the role of tumor-infiltrating lymphocytes (TILs). In certain breast cancer subtypes, the presence of TILs has prognostic value and is associated with clinical outcome and improved survival. The potential predictive value of TILs has also been investigated in regard to cytotoxic and antihuman epidermal growth factor receptor 2 (HER-2) therapies, but could also serve as a selection marker for novel immunotherapies. In this article, we review the current literature on TILs in breast cancer and discuss how TILs are emerging as a promising biomarker in mediating antitumor immunity.

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  1. New York University Langone Medical Center, New York, NY, USA

    Maryann Kwa & Sylvia Adams

  2. Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, 160 East 34th Street, New York, NY, 10016, USA

    Sylvia Adams

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  1. Maryann Kwa
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Maryann Kwa and Sylvia Adams declare that they have no conflict of interest.

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Kwa, M., Adams, S. Prognostic and Predictive Value of Tumor-Infiltrating Lymphocytes in Breast Cancer. Curr Breast Cancer Rep 8, 1–13 (2016). https://doi.org/10.1007/s12609-016-0198-3

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