Skip to main content
SpringerLink
Log in

Serum Ischemia-Modified Albumin in Preterm Babies with Respiratory Distress Syndrome

  • Original Article
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Infants with respiratory distress syndrome (RDS) may suffer from severe hypoxia, asphyxia. In this study, we aimed to evaluate serum ischemia-modified albumin (IMA) level as a diagnostic marker for hypoxia in preterm infants with RDS. Thirty-seven premature newborns with RDS were allocated as the study group and 42 healthy preterm neonates were selected as the control group. IMA was measured as absorbance unit (ABSU) in human serum with colorimetric assay method which is based on reduction in albumin cobalt binding. IMA levels were significantly higher in neonates with RDS as compared to the control group (P < 0.001). Cut-off value of IMA (ABSU) was 0.72, the sensitivity level was 91.9 %, the specificity was 78.6 %, positive predictive value was 79.1 % and negative predictive value was 91.7 % at RDS. Area under curve values was 0.93 (P < 0.001; 95 % CI, 0.88–0.98) in the receiver operating characteristic curve. We concluded that elevated blood IMA levels might be accepted as a useful marker for hypoxia in newborn with RDS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Rodrigez RJ, Martin RJ, Fanroff AA. Respiratory dystress syndrome and its manangement. In: Martin RJ, Fanaroff AA, Walsh MC, editors. Fanaroff and Matin’s neonatal perinatal disease of the fetus and infant. 8th ed. Philadelphia: Elsevier-Mosby; 2006. p. 1097–122.

    Google Scholar 

  2. Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, et al. European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants–2013 update. Neonatology. 2013;103:353–68.

    Article  PubMed  Google Scholar 

  3. Dani C, Reali MF, Bertini G, Wiechmann L, Spagnolo A, Tangucci M, et al. Risk factors for the development of respiratory distress syndrome and transient tachypnoea in newborn infants. Italian group of Neonatal Pneumology. Eur Respir J. 1999;14:155–9.

    Article  CAS  PubMed  Google Scholar 

  4. Gitto E, Reiter RJ, Karbownik M, Xian-Tan D, Barberi I. Respiratory distress syndrome in the newborn: role of oxidative stress. Intensive Care Med. 2001;27:1116–23.

    Article  CAS  PubMed  Google Scholar 

  5. Thornberg E, Thiringer K, Odeback A, Milsom I. Birth asphyxia: incidence, clinical course and outcome in a Swedish population. Acta Paediatr. 1995;84:927–32.

    Article  CAS  PubMed  Google Scholar 

  6. Nordstrom L, Arulkumaran S. Intrapartum fetal hypoxia and biochemical markers: a review. Obstet Gynecol Surv. 1998;53:645–57.

    Article  CAS  PubMed  Google Scholar 

  7. Gaze DC. Ischemia modified albumin: a novel biomarker for the detection of cardiac ischemia. Drug Metab Pharmacokinet. 2009;24:333–41.

    Article  CAS  PubMed  Google Scholar 

  8. Shen XL, Lin CJ, Han LL, Lin L, Pan L, Pu XD. Assessment of ischemia-modified albumin levels for emergency room diagnosis of acute coronary syndrome. Int J Cardiol. 2011;149:296–8.

    Article  PubMed  Google Scholar 

  9. Sadler PJ, Tucker A, Viles JH. Involvement of a lysine residue in the N-terminal Ni2+ and Cu2+ binding site of serum albumins. Comparison with Co2+, Cd2 + and Al3+. Eur J Biochem. 1994;220:193–200.

    Article  CAS  PubMed  Google Scholar 

  10. Caglar GS, Tasci Y, Goktolga U, Oztas E, Pabuccu R, Ozdemir ED, et al. Maternal and umbilical cord ischemia-modified albumin levels in nonreassuring fetal heart rate tracings regarding the mode of delivery. J Matern Fetal Neonatal Med. 2013;26:528–31.

    Article  CAS  PubMed  Google Scholar 

  11. Dursun A, Okumus N, Zenciroglu A. Ischemia-modified albumin (IMA): could it be useful to predict perinatal asphyxia? J Matern Fetal Neonatal Med. 2012;25:2401–5.

    Article  CAS  PubMed  Google Scholar 

  12. Kumral A, Okyay E, Guclu S, Gencpinar P, Islekel GH, Oguz SS, et al. Cord blood ischemia-modified albumin: is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia? J Obstet Gynaecol Res. 2013;39:663–71.

    Article  PubMed  Google Scholar 

  13. Yakut I, Tayman C, Oztekin O, Namuslu M, Karaca F, Kosus A. Ischemia-modified albumin may be a novel marker for the diagnosis and follow-up of necrotizing enterocolitis. J Clin Lab Anal. 2014;28:170–7.

    Article  CAS  PubMed  Google Scholar 

  14. Agrawal V, David RJ, Harris VJ. Classification of acute respiratory disorders of all newborns in a tertiary care center. J Natl Med Assoc. 2003;95:585–95.

    PubMed Central  PubMed  Google Scholar 

  15. Sbarouni E, Georgiadou P, Kremastinos DT, Voudris V. Ischemia modified albumin: is this marker of ischemia ready for prime time use? Hellenic J Cardiol. 2008;49:260–6.

    PubMed  Google Scholar 

  16. Gunduz A, Turkmen S, Turedi S, Mentese A, Yulug E, Ulusoy H, et al. Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia. Acad Emerg Med. 2009;16:539–43.

    Article  PubMed  Google Scholar 

  17. Ustün Y, Engin-Ustün Y, Oztürk O, Alanbay I, Yaman H. Ischemia-modified albumin as an oxidative stress marker in preeclampsia. J Matern Fetal Neonatal Med. 2011;24:418–21.

    Article  PubMed  Google Scholar 

  18. van Rijn BB, Franx A, Sikkema JM, van Rijn HJ, Bruinse HW, Voorbij HA, et al. Ischemia modified albumin in normal pregnancy and preeclampsia. Hypertens Pregnancy. 2008;27:159–67.

    Article  PubMed  Google Scholar 

  19. Gugliucci A, Hermo R, Monroy C, Numaguchi M, Kimura S. Ischemia-modified albumin levels in cord blood: a case-control study in uncomplicated and complicated deliveries. Clin Chim Acta. 2005;362:155–60.

    Article  CAS  PubMed  Google Scholar 

  20. Ukinc K, Eminagaoglu S, Ersoz HO, Erem C, Karahan C, Hacihasanoglu AB, et al. A novel indicator of widespread endothelial damage and ischemia in diabetic patients: ischemia-modified albumin. Endocrine. 2009;36:425–32.

    Article  CAS  PubMed  Google Scholar 

  21. Davis JM, Auten RL. Maturation of the antioxidant system and the effects on preterm birth. Semin Fetal Neonatal Med. 2010;15:191–5.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Neonatal Intencive Care Unit, Erzurum District Training and Research Hospital, Erzurum, Turkey

    Hasan Kahveci & Nazan Kavas

  2. Department of Neonatology, Denizli T.C. Public Health Hospital, 2010, Denizli, Turkey

    Cuneyt Tayman

  3. Division of Neonatal Intensive Care Unit, Nenehatun Obstetrics Hospital, Erzurum, Turkey

    Fuat Laoğlu

  4. Department of Biochemistry, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey

    Hüseyin Tugrul Celik

  5. Division of Pediatric Infectious Diseases, Erzurum District Training and Research Hospital, Erzurum, Turkey

    Ömer Kılıç

  6. Department of Pediatrics, Dr. Sami Ulus Children Research and Training Hospital, Ankara, Turkey

    Salih Aydemir

Authors
  1. Hasan Kahveci
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cuneyt Tayman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fuat Laoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hüseyin Tugrul Celik
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nazan Kavas
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ömer Kılıç
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Salih Aydemir
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cuneyt Tayman.

Additional information

Hasan Kahveci and Cuneyt Tayman are the first author.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kahveci, H., Tayman, C., Laoğlu, F. et al. Serum Ischemia-Modified Albumin in Preterm Babies with Respiratory Distress Syndrome. Ind J Clin Biochem 31, 38–42 (2016). https://doi.org/10.1007/s12291-015-0494-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12291-015-0494-0

Keywords

Search

Navigation