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Potential use of glioblastoma tumorsphere: clinical credentialing

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Abstract

A decade ago, cancer stem cells (CSCs) were introduced as target cells for an innovative cancer treatment. Particularly, there have been a lot of biological researches on glioblastoma (GBM) CSCs. However, as there is a comprehensive change in the concept of CSCs, it is required to review how the different CSCs for patients can be clinically used, or clinical credentialing, and summarize the possibilities of clinical credentialing. In this regard, this review aims to introduce the tumorsphere obtained from GBM specimen and summarize the clinical dilemma and clinically applicable areas.

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Acknowledgments

This study was supported by the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI14C0042).

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The authors declare no relevant conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea

    Seok-Gu Kang, Eui Hyun Kim, Sun Ho Kim & Jong Hee Chang

  2. Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Jae-Ho Cheong

  3. Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Yong Min Huh

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  1. Seok-Gu Kang
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  2. Jae-Ho Cheong
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  3. Yong Min Huh
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  4. Eui Hyun Kim
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  5. Sun Ho Kim
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Correspondence to Seok-Gu Kang or Jong Hee Chang.

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Kang, SG., Cheong, JH., Huh, Y.M. et al. Potential use of glioblastoma tumorsphere: clinical credentialing. Arch. Pharm. Res. 38, 402–407 (2015). https://doi.org/10.1007/s12272-015-0564-0

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  • DOI: https://doi.org/10.1007/s12272-015-0564-0

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