Abstract
The increase in obesity and cardiovascular disease (CVD) is a major problem in developed countries. As a consequence, metabolic syndrome, a disorder that links obesity and CVD, is becoming an important health concern. The underlying mechanisms of metabolic syndrome are considered to be excess visceral fat accumulation and insulin resistance. Visceral adipose tissue essentially takes up and stores excess energy and buffers against hyperglycemia and hyperlipidemia. However, excess visceral fat accumulation causes dysregulation of various adipocyte-derived bioactive molecules (adipocytokines), which leads to chronic systemic low-grade inflammation and CVD. The reduction of visceral fat through lifestyle modification is a potentially useful strategy for the prevention of CVD. Waist circumference is a good surrogate marker of visceral fat accumulation and is useful for monitoring the results of lifestyle changes. Moreover, adipocytokines are useful biomarkers and therapeutic targets for obesity-induced CVD.
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Shinji Kihara and Yuji Matsuzawa declare that they have no conflict of interest.
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Kihara, S., Matsuzawa, Y. Fat Distribution and Cardiovascular Disease Risk. Curr Cardiovasc Risk Rep 9, 8 (2015). https://doi.org/10.1007/s12170-015-0439-4
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DOI: https://doi.org/10.1007/s12170-015-0439-4