Skip to main content

Advertisement

Log in

Evidence for Psychosocial Risk Factors and Behavioral Interventions in Cardiovascular Disease

  • Tobacco Use and Lifestyle (HA Tindle, Section Editor)
  • Published:
Current Cardiovascular Risk Reports Aims and scope Submit manuscript

Abstract

Over nearly a half century, epidemiologic studies have shown a strong relationship between several psychosocial variables and the risk of coronary heart disease. Key factors include negative thought patterns and emotions, specifically depressive syndromes, anxiety syndromes, hostility and anger, worry and pessimism. Chronic stress factors include work stress, social isolation, and low socioeconomic status. Positive psychological factors include optimism, social support and sense of purpose. Clinical trials involving behavioral interventions such as those focusing on type A behavior or depression, have had mixed results. Simple psychosocial evaluation recommended includes an inventory for assessing depression given its predominance as a psychosocial factor consistently associated with cardiovascular disease risk. Screening for other factors of psychosocial stress as well as carefully planned multidisciplinary management is also recommended to maximize the likelihood of adherence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Friedman M, Rosenman RH. Association of specific overt behavior with blood and cardiovascular findings. JAMA. 1959;169:1286.

    Article  CAS  Google Scholar 

  2. •• Rozanski A. Chapter 34: Psychological risk factors and coronary artery disease: epidemiology, pathyphysiology, and management. In: Blumenthal R, Foody J, Wong ND, editors. Preventive Cardiology. New York: Elsevier; 2011. This comprehensive book chapter reviews the major psychosocial factors and their relation to cardiovascular disease as well as clinical trial evidence for reducing cardiovascular risk from psychosocial interventions.

    Google Scholar 

  3. Rozanski A, Blumenthal JA, Davidson KW, et al. The epidemiology, pathophysiology and management of psychological risk factors in cardiac practice: the emerging field of behavioral cardiology. J Am Coll Cardiol. 2005;45:637.

    Article  PubMed  Google Scholar 

  4. Yusuf S, Hawken S, Ounpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case control study. Lancet. 2004;364:937.

    Article  PubMed  Google Scholar 

  5. Frasure-Smith N, Lespérance F, Talajic M. Depression following myocardial infarction. Impact on 6-month survival. JAMA. 1993;270(15):1819–25.

    Article  PubMed  CAS  Google Scholar 

  6. Rugulies R. Depression as a predictor for coronary heart disease. A review and meta-analysis. Am J Prev Med. 2002;23:51.

    Article  PubMed  Google Scholar 

  7. Lesperance F, Frasure-Smith N, Talajiv M, et al. Five-year risk of cardiac mortality in relation to initial severity and one-year change sin depression symptoms after myocardial infarction. Circulation. 2002;105:1049.

    Article  PubMed  Google Scholar 

  8. Broadley AJ, Korszen A, Jones CJ, Frenneaux MP. Arterial endothelial function is impaired in treated depression. Heart. 2002;88:521.

    Article  PubMed  CAS  Google Scholar 

  9. • Whang W, Shimbo D, Kronish IM, et al. Depressive symptoms and all-cause mortality in unstable angina pectoris (from the Coronary Psychosocial Evaluation Studies [COPES]). Am J Cardiol. 2010;106:1104–7. This recent study further documents the prognostic significance of depression in cardiac patients.

    Article  PubMed  Google Scholar 

  10. Frasure-Smith N, Lesperance F. Depression and anxiety as predictors of 2-year cardiac events in patients with stable coronary artery disease. Arch Gen Psychiatry. 2008;65:62.

    Article  PubMed  CAS  Google Scholar 

  11. Kawachi I, Sparrow D, Vokonas PS, Weiss ST. Symptoms of anxiety and risk of coronary heart disease. The Normative Aging Study. Circulation. 1994;90(5):2225–9.

    Article  PubMed  CAS  Google Scholar 

  12. Kubansky LD, Koenen KC, Spiro A, et al. Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study. Arch Gen Psychatry. 2007;64:109.

    Article  Google Scholar 

  13. Kubansky LD, Koenen KC, Jones C, et al. A prospective study of posttraumatic stress disorder symptoms and coronary heart disease in women. Health Psychol. 2009;28:125.

    Article  Google Scholar 

  14. Boscarino JA. A prospective study of PTSD and early-age heart disease mortality among Vietnam veterans: implications for surveillance and prevention. Psychosom Med. 2008;70:668.

    Article  PubMed  Google Scholar 

  15. Grodbardt BR, Bower JH, Geda YE, et al. Pessimistic, anxious, and depressive personality traits predict all-cause mortality: the Mayo Clinic Cohort Study of Personality and Aging. Psychosom Med. 2009;71:491. This large study further documents the importance of pessimism as a predictor of all-cause mortality.

    Article  Google Scholar 

  16. •• Tindle HA, Chang YF, Kuller LH, et al. Optimism, cynical hostility, and incident coronary heart disease and mortality in the Women’s Health Initiative. Circulation. 2009;120:656. This very large study from the well-known Women’s Health Initiative documents the importance of optimism being related to reduced cardiovascular disease risk.

    Article  PubMed  Google Scholar 

  17. Niaura R, Todaro JF, Stroud L, Spiro 3rd A, Ward KD, Weiss S. Hostility, the metabolic syndrome, and incident coronary heart disease. Health Psychol. 2002;21:588.

    Article  PubMed  Google Scholar 

  18. Rozanski A, Blumenthal JA, Kaplan J. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation. 1999;99:2192.

    Article  PubMed  CAS  Google Scholar 

  19. Haukkala A, Konttinen H, Laatikainen T, Kawachi I, Uutela A. Hostility, anger control, and anger expression as predictors of cardiovascular disease. Psychosom Med. 2010;72:556–62.

    Article  PubMed  Google Scholar 

  20. Davidson KW, Mostofsky E. Anger expression and risk of coronary heart disease: evidence from the Nova Scotia Health Survey. Am Heart J. 2010;159:199–206.

    Article  PubMed  Google Scholar 

  21. Berkman LF, Syme SL. Social networks, host resistance, and mortality: a none-year follow-up study of Alameda county residents. Am J Epidemiol. 1979;109:186.

    PubMed  CAS  Google Scholar 

  22. House JS, Robbins C, Metzner HL. The association of social relationships and activities with mortality: prospective evidence from the Tecumseh Community Health Study. Am J Epidemiol. 1982;116:123–40.

    PubMed  CAS  Google Scholar 

  23. Gallo LC, Troxel WM, Kuller LH, Sutton-Tyrrell K, Edmundowicz D, Matthews KA. Marital status, marital quality, and atherosclerotic burden in postmenopausal women. Psychosom Med. 2003;65:952.

    Article  PubMed  Google Scholar 

  24. Chida Y, Steptoe A. Positive psycholocial well-being and mortality: a quantative review of prospective observational studies. Psychosom Med. 2008;70:741.

    Article  PubMed  Google Scholar 

  25. Boyle PA, Barnes LL, Buchman AS, et al. Purpose in life is associated with mortality amog community-dwelling older persons. Psychosom Med. 2009;71:575.

    Article  Google Scholar 

  26. Falk A, Hanson BS, Isacsson SO, Ostergren PO. Job strain and mortality in elderly men: social network, support, and influence as buffers. Am J Public Health. 1992;82:1136–9.

    Article  PubMed  CAS  Google Scholar 

  27. Bosma A, Marmot MG, Hemingway H, et al. Low job control and riskof coronary heart disease in Whitehall II (prospective cohort) study. BMJ. 1997;314:558.

    Article  PubMed  CAS  Google Scholar 

  28. Kuper H, Marmot M, Hemingway H. Systematic review of prospective cohort studies of psychosocial factors in the etiology and prognosis of coronary heart disease. Semin Vasc Med. 2002;2:267.

    Article  PubMed  Google Scholar 

  29. Peter R, Siegrist H, Hallqvist J, et al. Psychosocial work environment and myocardial infarction: improving risk estimating by combining two complementary job stress models in the SHEEP study. J Epidemiol Community Health. 2002;56:294.

    Article  PubMed  CAS  Google Scholar 

  30. • Fujishiro K, Diez Rouz AV, Landsbergis P, et al. Associations of occupation, job control and job demands with intima-media thickness: the Multiethnic Study of Atherosclerosis (MESA). Occup Enciron Med. 2011;68:319–26. This interesting study documents the relation of lack of job control with subclinical atherosclerosis measured by carotid intima-media thickness in the well-characterized MESA cohort.

    Article  Google Scholar 

  31. Friedman M, Thoresen CE, Gill JJ, Ulmer D, Powell LH, Price VA, Brown B, Thompson L, Rabin DD, Breall WS, et al. Alteration of type A behavior and its effect on cardiac recurrences in post myocardial infarction patients: summary results of the recurrent coronary prevention project. Am Heart J. 1986;112:653.

    Article  PubMed  CAS  Google Scholar 

  32. ••Rees K, Bennett P, West R, et al. Psychosocial interventions for coronary heart disease. Cochane Database Syst Rev. 2009;3:1. This large meta-analysis raises question about the efficacy of psychosocial interventions in reducing coronary heart disease risk.

    Google Scholar 

  33. Linden W, Phillips MJ, Leclerc J. Psychological treatment of cardiac patients: a meta-analysis. Eur Heart J. 2007;28:2972.

    Article  PubMed  Google Scholar 

  34. The ENRICHD. Investigators: Effects on treating depression and low perceived social support on clinical events after a myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) randomized trial. JAMA. 2003;289:3106.

    Article  Google Scholar 

  35. Carney RM, Blumenthal JA, Freedland KE, et al. Depression and late mortality after myocardial infarction in the Enhancing Recovery in Coronary Heart Disease (ENCICHD) Study. Psychosom Med. 2004;66:466.

    Article  PubMed  Google Scholar 

  36. Frasure-Smith N, Lespérance F, Prince RH, Verrier P, Garber RA, Juneau M, Wolfson C, Bourassa MG. Randomised trial of home-based psychosocial nursing intervention for patients recovering from myocardial infarction. Lancet. 1997;350:473.

    Article  PubMed  CAS  Google Scholar 

  37. Frasure-Smith N, Lespérance F, Gravel G, Masson A, Juneau M, Bourassa MG. Long-term survival differences among low-anxious, high-anxious and repressive copers enrolled in the Montreal heart attack readjustment trial. Psychosom Med. 2002;64:571.

    Article  PubMed  Google Scholar 

  38. Gulliksson M, Burell G, Vessby B, Lundin L, Toss H, Svardsudd K. Randomized controlled trial of cognitive behavioral therapy vs standard treatment to prevent recurrent cardiovascular events in patients with coronary heart disease: Secondary Prevention in Uppsala Primary Health Care project (SUPRIM). Arch Intern Med. 2011;171:134–40.

    Article  PubMed  Google Scholar 

  39. Lichtman JH, Bigger JT, Blumenthal JA, et al. Depression and coronary heart disease recommendations for screening, referral and treatment. Circulation. 2008;118:1768.

    Article  PubMed  Google Scholar 

  40. Smoller JW, Allison M, Cochrane BB, et al. Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women’s Health Initiative study. Arch Intern Med. 2010;169:2128.

    Article  Google Scholar 

  41. Whang W, Kubzansky LD, Kawachi I, et al. Depression and risk of sudden cardiac death and coronary heart disease in women. J Am Coll Cardiol. 2009;53:950.

    Article  PubMed  Google Scholar 

Download references

Disclosure

No potential conflicts of interest relevant to this article were reported.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nathan D. Wong.

Additional information

Presented and adapted from the proceedings of the conference “Psychosocial Factor and Cardiovascular Disease,” sponsored by the Academy of Sciences and Arts, Republic of Srpska, Bosnia and Herzegovina, September 2011.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wong, N.D. Evidence for Psychosocial Risk Factors and Behavioral Interventions in Cardiovascular Disease. Curr Cardiovasc Risk Rep 6, 528–533 (2012). https://doi.org/10.1007/s12170-012-0270-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12170-012-0270-0

Keywords

Navigation