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Multiple Malignant Salivary Gland Neoplasms: Mucoepidermoid Carcinoma of Palate and Adenoid Cystic Carcinoma of Floor of Mouth

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Abstract

Salivary gland tumors usually occur as single lesions. To have more than one tumor is unusual. We report a case of an adult male who presented with a mucoepidermoid carcinoma involving the minor salivary glands of the palate at age 57 years, followed by an adenoid cystic carcinoma of the floor of mouth at age 63 years. The patient later succumbed to non-Hodgkin lymphoma at age 72 years. There are 31 acceptable cases of multiple malignant salivary gland neoplasms reported in the world literature. Multiple malignant tumors of the same histologic type are more common than those of different histologic type. Bilateral acinic cell adenocarcinoma was the most frequent combination of multiple salivary gland malignancy, accounting for 14 cases (10 synchronous and four metachronous). All involved the parotid glands bilaterally with the exception of one case that involved parotid and submandibular gland. Polymorphous low-grade adenocarcinoma accounted for three of the four cases of multiple malignant tumors involving minor salivary glands. Individuals with a history of malignancy are at risk for the development of additional malignant tumors and should receive appropriate clinical follow-up.

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Notes

  1. Simultaneous or autochronous

  2. Asynchronous

  3. We were unable to locate the source of the report of unilateral synchronous adenoid cystic carcinoma and sebaceous adenocarcinoma of parotid gland in Table 3 of Gnepp et al. [2] due to a typographic error in the published citation.

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Acknowledgements

The authors would like to express their appreciation to Mr. Harry W. Mueller for his outstanding bibliographic support services.

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Authors and Affiliations

  1. Oral and Maxillofacial Pathology, School of Dentistry, University of Missouri, 650 E. 25th Street, Kansas City, MO, 64108-6489, USA

    Joseph C. Whitt

  2. Department of Oral and Maxillofacial Pathology, Armed Forces Institute of Pathology, Washington, DC, USA

    Duane R. Schafer

  3. Retired, Woodbine, GA, USA

    Michael D. Callihan

Authors
  1. Joseph C. Whitt
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  2. Duane R. Schafer
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  3. Michael D. Callihan
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Correspondence to Joseph C. Whitt.

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This paper was presented at the 59th Annual Meeting of the American Academy of Oral and Maxillofacial Pathology, Charleston, SC, May 11, 2004.

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Whitt, J.C., Schafer, D.R. & Callihan, M.D. Multiple Malignant Salivary Gland Neoplasms: Mucoepidermoid Carcinoma of Palate and Adenoid Cystic Carcinoma of Floor of Mouth. Head and Neck Pathol 2, 41–48 (2008). https://doi.org/10.1007/s12105-007-0026-1

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