Skip to main content

Advertisement

SpringerLink
Log in

Lipomas of the Oral Cavity: Clinicopathological and Immunohistochemical Study of 24 Cases and Review of the Literature

  • Original Article
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Although lipomas are common soft tissue tumors, few cases of lipoma or its variants have been reported in the oral cavity. We here described the clinical, histological, and immunohistochemical features of 24 cases of oral lipoma obtained from medical records at Nagasaki University Hospital between 1977 and 2010, and also retrospectively reviewed 603 cases of oral lipoma reported in the English literatures. The patients examined comprised 11 men and 13 women with a mean age of 59 years, ranging from 31 to 90 years. The main sites involved were the buccal mucosa (n = 9), followed by the tongue (n = 4), lip and retromolar area (n = 3), floor of the mouth (n = 2), and gingiva (n = 1). The mean tumor size was 2.0 cm, ranging from 0.2 to 5 cm. Histological analysis revealed 20 cases of lipoma, 2 cases of fibrolipoma, and one case each of intramuscular lipoma and spindle cell lipoma. Twenty-three cases were treated surgically while one case underwent biopsy and follow-up. Recurrence was not observed in any case. We reviewed the English literatures, and similar results were obtained. In immunohistochemical analysis, PCNA and ki-67 expression indices were higher in intramuscular lipoma cases than in its variants. Especially, it showed that a long time follow-up may be necessary in ki-67 positive cases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

Abbreviations

F:

Female

M:

Male

cm:

Centimeters

NA:

Not available

References

  1. Neville BW, Damm DD, Allen CM, Bouquot JE (2009) Oral and maxillofacial pathology, 3rd edn. Saunders, Elsevier, pp 523–524

    Google Scholar 

  2. Bertelli AP (1965) Uncommon tumors of the tongue (lipoma and leiomyofibroma); report of two cases. Oral Surg Oral Med Oral Pathol 19:771–775

    Article  Google Scholar 

  3. Lombardi T, Odell EW (1994) Spindle cell lipoma of the oral cavity: report of a case. J Oral Pathol Med 23:237–239

    Article  CAS  PubMed  Google Scholar 

  4. Fregnami ER, Pires FR, Falzoni R, Lopes MA, Vargas PA (2002) Lipomas of the oral cavity: clinical findings, histological classification and proliferative activity of 46 cases. Int J Oral Maxillofac Surg 32:49–53

    Article  Google Scholar 

  5. Epivatianos A, Markopoulos AK, Papanayotou P (2000) Benign tumors of adipose tissue of the oral cavity: a clinicopathologic study of 13 cases. J Oral Macillofac Surg 58:1113–1117

    Article  CAS  Google Scholar 

  6. De Freitas MA, Freitas VS, de lima AA, Pereira FB Jr, dos Santos JN (2009) Intraoral lipomas; a study of 26 cases in a Brazilian population. Quintessence Int 40:79–85

  7. Studart-Soares EC, Costa FW, Sousa FB, Alves AP, Osterne RL (2010) Oral lipomas in a Brazilian population: a 10-year study and analysis of 450 cases reported in the literature. Med Oral Patol Oral Cir Bucal 15(5):e691–e696

    Article  PubMed  Google Scholar 

  8. Juliasse LE, Nonaka CF, Pinto LP, Freitas Rde A, Miguel MC (2010) Lipomas of the oral cavity: clinical and histopathologic study of 41 cases in a Brazilian population. Eur Arch Otorhinolaryngol 267(3):459–465

    Article  PubMed  Google Scholar 

  9. Seldin HM, Seldin SD, Rakower W, Jarrett WJ (1967) Lipomas of oral cavity: report of 26 cases. J Oral Surg 25(3):270–274

    CAS  PubMed  Google Scholar 

  10. MacGregor AJ, Dyson DP (1966) Oral lipoma. A review of the literature and report of twelve new cases. Oral Surg Oral Med Oral Pathol 21(6):770–777

    Article  CAS  PubMed  Google Scholar 

  11. Hatziotis JC (1971) Lipoma of the oral cavity. Oral Surg Oral Med Oral Pathol 31(4):511–524

    Article  CAS  PubMed  Google Scholar 

  12. Greer RO, Richardson JF (1973) The nature of lipomas and their significance in the oral cavity. Oral Surg Oral Med Oral Pathol 36(4):551–557

    Article  CAS  PubMed  Google Scholar 

  13. de Visscher JG (1982) Lipomas and fibrolipomas of the oral cavity. J Maxillofac Surg 10(3):177–181

    Article  PubMed  Google Scholar 

  14. Said-Al-Naief N, Zahurullah FR, Sciubba JJ (2001) Oral spindle cell lipoma. Ann Diagn Pathol 5(4):207–215

    Article  CAS  PubMed  Google Scholar 

  15. Manor E, Sion-Vardy N, Joshua BZ, Bodner L (2011) Oral lipoma: analysis of 58 new cases and review of the literature. Ann Diagn Pathol 15(4):257–261

    Article  PubMed  Google Scholar 

  16. Furlong MA, Fanburg-Smith JC, Childers EL (2004) Lipomas of the oral and maxillofacial region: site and subclassification of 125 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:441–450

    Article  PubMed  Google Scholar 

  17. Kim JW, Kang SJ (2012) Pediatric lipoma of the buccal fat pad. J Craniofac Surg 23(6):1934–1935

    Article  PubMed  Google Scholar 

  18. Sato H, Gotoh C, Uchida H, Kawashima H, Yoshida M, Kitano Y, Kishimoto H (2011) Sialolipoma of the submandibular gland in a child. J Pediatr Surg 46(2):408–410

    Article  PubMed  Google Scholar 

  19. Gokul S, Ranjini KV, Kirankumar K, Hallikeri K (2009) Congenital osteolipoma associated with cleft palate: a case report. Int J Oral Maxillofac Surg 38(1):91–93

    Article  CAS  PubMed  Google Scholar 

  20. Lerosey Y, Choussy O, Gruyer X, Francois A, Marie JP, Dehesdin D et al (1999) Infiltrating lipoma of the head and neck: a report of one pediatric case. Int J Pediatr Otorhinolaryngol 47(1):91–95

    Article  CAS  PubMed  Google Scholar 

  21. Dattilo DJ, Iqe JT, Nwana EJ (1996) Intraoral lipoma of the tongue and submandibular space: report of a case. J Oral Maxillofac Surg 54(7):915–917

    Article  CAS  PubMed  Google Scholar 

  22. Naruse T, Yanamoto S, Kawano T, Yoshitomi I, Yamada S, Kawasaki G et al (2012) Intramuscular lipoma of the tongue: report of a case complicated with diffuse lipomatosis. J Oral Maxillofac Surg Med Pathol 24:237–240

    Article  Google Scholar 

  23. Scherl MP, Som PM, Biller HF, Shah K (1986) Recurrent infiltrating lipoma of the head and neck: case report and literature review. Arch Otolaryngol Head Neck Surg 112:1210–1212

    Article  CAS  PubMed  Google Scholar 

  24. Lacey MS, Craig I (1995) Infiltrating lipoma of the face. Ann Plast Surg 35:307–309

    Article  CAS  PubMed  Google Scholar 

  25. Hatano H, Morita T, Ogose A, Hotta T, Kobayashi H, Honma K (2004) Well-differentiated liposarcoma associated with benign lipoma. Anticancer Res 24(2C):1039–1044

    PubMed  Google Scholar 

  26. Kindblom LG, Meis-Kindblom JM (1995) Chondroid lipoma: an ultrastructural and immunohistochemical analysis with further observations regarding its differentiation. Hum Pathol 26(7):706–715

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

None declared.

Author information

Authors and Affiliations

  1. Unit of Translational Medicines, Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan

    Tomofumi Naruse, Souichi Yanamoto, Shin-ichi Yamada, Satoshi Rokutanda, Akiko Kawakita, Hidenori Takahashi, Yuki Matsushita, Saki Hayashida, Naomi Imayama, Kota Morishita, Kentaro Yamashita, Goro Kawasaki & Masahiro Umeda

Authors
  1. Tomofumi Naruse
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Souichi Yanamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shin-ichi Yamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Satoshi Rokutanda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Akiko Kawakita
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hidenori Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yuki Matsushita
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Saki Hayashida
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Naomi Imayama
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Kota Morishita
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Kentaro Yamashita
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Goro Kawasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Masahiro Umeda
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tomofumi Naruse.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Naruse, T., Yanamoto, S., Yamada, Si. et al. Lipomas of the Oral Cavity: Clinicopathological and Immunohistochemical Study of 24 Cases and Review of the Literature. Indian J Otolaryngol Head Neck Surg 67 (Suppl 1), 67–73 (2015). https://doi.org/10.1007/s12070-014-0765-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12070-014-0765-8

Keywords

Search

Navigation