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Well-Differentiated Liposarcoma (Atypical Lipomatous Tumor) Presenting as an Esophageal Polyp

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References

  1. Lin Z-C, Chang X-Z, Huang X-F, Zhang C-L, G-S Y, S-Y W, et al. Giant liposarcoma of the esophagus: a case report. World J Gastroenterol. 2015;21(33):9827–32. https://doi.org/10.3748/wjg.v21.i33.9827.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Myung JK, Jeong JB, Han D, Song CS, Moon HJ, Kim YA, et al. Well-differentiated liposarcoma of the oesophagus: clinicopathological, immunohistochemical and array CGH analysis. Pathol Oncol Res. 2011;17(2):415–20. https://doi.org/10.1007/s12253-010-9322-2.

    Article  PubMed  Google Scholar 

  3. Boni A, Lisovsky M, Dal Cin P, Rosenberg AE, Srivastava A. Atypical lipomatous tumor mimicking giant fibrovascular polyp of the esophagus: report of a case and a critical review of literature. Hum Pathol. 2013;44(6):1165–70. https://doi.org/10.1016/j.humpath.2012.10.023.

    Article  PubMed  Google Scholar 

  4. Liakakos TD, Troupis TG, Tzathas C, Spirou K, Nikolaou I, Ladas S, et al. Primary liposarcoma of esophagus: a case report. World J Gastroenterol. 2006;12(7):1149–52. https://doi.org/10.3748/wjg.v12.i7.1149.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Graham RP, Yasir S, Fritchie KJ, Reid MD, Greipp PT, Folpe AL. Polypoid fibroadipose tumors of the esophagus: ‘giant fibrovascular polyp’ or liposarcoma? A clinicopathological and molecular cytogenetic study of 13 cases. Mod Pathol. 2017; https://doi.org/10.1038/modpathol.2017.140.

  6. Park JS, Bang BW, Shin J, Kwon KS, Kim HG, Shin YW, et al. A case of esophageal fibrovascular polyp that induced asphyxia during sleep. Clin Endosc. 2014;47(1):101–3. https://doi.org/10.5946/ce.2014.47.1.101.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Sweeney T. Giant fibrovascular polyp causing complete oesophageal obstruction. ANZ J Surg. 2011;81(11):845–6. https://doi.org/10.1111/j.1445-2197.2011.05877.x.

    Article  PubMed  Google Scholar 

  8. Sargent RL, Hood IC. Asphyxiation caused by giant fibrovascular polyp of the esophagus. Arch Pathol Lab Med. 2006;130(5):725–7.

  9. Yu Z, Bane BL, Lee JY, Pitha JV, Peyton M, Houck J, et al. Cytogenetic and comparative genomic hybridization studies of an esophageal giant fibrovascular polyp: a case report. Hum Pathol. 2012;43(2):293–8. https://doi.org/10.1016/j.humpath.2011.04.022.

    Article  PubMed  Google Scholar 

  10. Jakowski JD, Wakely PE Jr. Rhabdomyomatous well-differentiated liposarcoma arising in giant fibrovascular polyp of the esophagus. Ann Diagn Pathol. 2009;13(4):263–8. https://doi.org/10.1016/j.anndiagpath.2008.04.004.

    Article  PubMed  Google Scholar 

  11. Beylergil V, Simmons MZ, Ulaner G, Jurcic J, Hibshoosh H, Carrasquillo JA. FDG PET/CT findings in a rare case of giant fibrovascular polyp of the esophagus harboring atypical lipomatous tumor/well-differentiated liposarcoma. Clin Nucl Med. 2014;39(3):288–91. https://doi.org/10.1097/RLU.0000000000000358.

    Article  PubMed  Google Scholar 

  12. Nascimento AG. Dedifferentiated liposarcoma. Semin Diagn Pathol. 2001;18(4):263–6.

    CAS  PubMed  Google Scholar 

  13. Laurino L, Furlanetto A, Orvieto E, Dei Tos AP. Well-differentiated liposarcoma (atypical lipomatous tumors). Semin Diagn Pathol. 2001;18(4):258–62.

    CAS  PubMed  Google Scholar 

  14. Fletcher CD. The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology. 2006;48(1):3–12. https://doi.org/10.1111/j.1365-2559.2005.02284.x.

    Article  CAS  PubMed  Google Scholar 

  15. Michal M, Kazakov DV, Hadravsky L, Michalova K, Grossmann P, Steiner P, et al. Lipoblasts in spindle cell and pleomorphic lipomas: a close scrutiny. Hum Pathol. 2017;65:140–6. https://doi.org/10.1016/j.humpath.2017.05.006.

    Article  CAS  PubMed  Google Scholar 

  16. Mertens F, Panagopoulos I, Mandahl N. Genomic characteristics of soft tissue sarcomas. Virchows Arch. 2010;456(2):129–39. https://doi.org/10.1007/s00428-009-0736-8.

    Article  PubMed  Google Scholar 

  17. Sirvent N, Coindre JM, Maire G, Hostein I, Keslair F, Guillou L, et al. Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 2007;31(10):1476–89. https://doi.org/10.1097/PAS.0b013e3180581fff.

    Article  Google Scholar 

  18. Weaver J, Rao P, Goldblum JR, Joyce MJ, Turner SL, Lazar AJ, et al. Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma? Mod Pathol. 2010;23(10):1301–6. https://doi.org/10.1038/modpathol.2010.106.

    Article  CAS  PubMed  Google Scholar 

  19. Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell. 2006;127(2):265–75. https://doi.org/10.1016/j.cell.2006.10.003.

    Article  CAS  PubMed  Google Scholar 

  20. Louis-Brennetot C, Coindre JM, Ferreira C, Pérot G, Terrier P, Aurias A. The CDKN2A/CDKN2B/CDK4/CCND1 pathway is pivotal in well-differentiated and dedifferentiated liposarcoma oncogenesis: an analysis of 104 tumors. Genes Chromosomes Cancer. 2011;50(11):896–907. https://doi.org/10.1002/gcc.20909.

    Article  CAS  PubMed  Google Scholar 

  21. Henricks WH, Chu YC, Goldblum JR, Weiss SW. Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation. Am J Surg Pathol. 1997;21(3):271–81. https://doi.org/10.1097/00000478-199703000-00002.

    Article  CAS  Google Scholar 

  22. Thway K, Jones RL, Noujaim J, Zaidi S, Miah AB, Fisher C. Dedifferentiated Liposarcoma: updates on morphology, genetics, and therapeutic strategies. Adv Anat Pathol. 2016;23(1):30–40. https://doi.org/10.1097/PAP.0000000000000101.

    Article  CAS  Google Scholar 

  23. Weiss SW, Rao VK. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites. A follow-up study of 92 cases with analysis of the incidence of “dedifferentiation”. Am J Surg Pathol. 1992;16(11):1051–8. https://doi.org/10.1097/00000478-199211000-00003.

    Article  CAS  PubMed  Google Scholar 

  24. Lucas DR, Nascimento AG, Sanjay BK, Rock MG. Well-differentiated liposarcoma. The Mayo Clinic experience with 58 cases. Am J Clin Pathol. 1994;102(5):677–83. https://doi.org/10.1093/ajcp/102.5.677.

    Article  CAS  PubMed  Google Scholar 

  25. Hasegawa T, Seki K, Hasegawa F, Matsuno Y, Shimodo T, Hirose T, et al. Dedifferentiated liposarcoma of retroperitoneum and mesentery: varied growth patterns and histological grades—a clinicopathologic study of 32 cases. Hum Pathol. 2000;31(6):717–27. https://doi.org/10.1053/hupa.2000.8222.

    Article  CAS  PubMed  Google Scholar 

  26. McCormick D, Mentzel T, Beham A, Fletcher CD. Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. Am J Surg Pathol. 1994;18(12):1213–23. https://doi.org/10.1097/00000478-199412000-00004.

    Article  CAS  PubMed  Google Scholar 

  27. Nascimento AG, Kurtin PJ, Guillou L, Fletcher CD. Dedifferentiated liposarcoma: a report of nine cases with a peculiar neurallike whorling pattern associated with metaplastic bone formation. Am J Surg Pathol. 1998;22(8):945–55. https://doi.org/10.1097/00000478-199808000-00004.

    Article  CAS  PubMed  Google Scholar 

  28. Fanburg-Smith JC, Miettinen M. Liposarcoma with meningothelial-like whorls: a study of 17 cases of a distinctive histological pattern associated with dedifferentiated liposarcoma. Histopathology. 1998;33(5):414–24. https://doi.org/10.1046/j.1365-2559.1998.00536.x.

    Article  CAS  PubMed  Google Scholar 

  29. Thway K, Robertson D, Thway Y, Fisher C. Dedifferentiated liposarcoma with meningothelial-like whorls, metaplastic bone formation, and CDK4, MDM2, and p16 expression: a morphologic and immunohistochemical study. Am J Surg Pathol. 2011;35(3):356–63. https://doi.org/10.1097/PAS.0b013e31820832c1.

    Article  PubMed  Google Scholar 

  30. Marino-Enriquez A, Fletcher CD, Dal Cin P, Hornick JL. Dedifferentiated liposarcoma with “homologous” lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. Am J Surg Pathol. 2010;34(8):1122–31. https://doi.org/10.1097/PAS.0b013e3181e5dc49.

    Article  PubMed  Google Scholar 

  31. Binh MB, Guillou L, Hostein I, Chateau MC, Collin F, Aurias A, et al. Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas. Am J Surg Pathol. 2007;31(10):1557–66. https://doi.org/10.1097/PAS.0b013e31804b4109.

    Article  PubMed  Google Scholar 

  32. Evans HL, Khurana KK, Kemp BL, Ayala AG. Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma. Am J Surg Pathol. 1994;18(11):1150–7. https://doi.org/10.1097/00000478-199411000-00009.

    Article  CAS  PubMed  Google Scholar 

  33. Fukunaga M. Histologically low-grade dedifferentiated liposarcoma of the retroperitoneum. Pathol Int. 2001;51(5):392–5. https://doi.org/10.1046/j.1440-1827.2001.01208.x.

    Article  CAS  PubMed  Google Scholar 

  34. Azumi N, Curtis J, Kempson RL, Hendrickson MR. Atypical and malignant neoplasms showing lipomatous differentiation. A study of 111 cases. Am J Surg Pathol. 1987;11(3):161–83. https://doi.org/10.1097/00000478-198703000-00001.

    Article  CAS  PubMed  Google Scholar 

  35. Cancer Genome Atlas Research Network, Abeshouse A, Adebamowo C, Adebamowo SN, Akbani R, Akeredolu T, et al. Comprehensive and integrated genomic characterization of adult soft tissue sarcomas. Cell. 2017;171(4):950–65.e28.

    Article  Google Scholar 

  36. Binh MB, Sastre-Garau X, Guillou L, de Pinieux G, Terrier P, Lagacé R, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol. 2005;29(10):1340–7. https://doi.org/10.1097/01.pas.0000170343.09562.39.

    Article  PubMed  Google Scholar 

  37. Weaver J, Downs-Kelly E, Goldblum JR, Turner S, Kulkarni S, Tubbs RR, et al. Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol. 2008;21(8):943–9. https://doi.org/10.1038/modpathol.2008.84.

    Article  CAS  PubMed  Google Scholar 

  38. Thway K, Flora R, Shah C, Olmos D, Fisher C. Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors. Am J Surg Pathol. 2012;36(3):462–9. https://doi.org/10.1097/PAS.0b013e3182417330.

    Article  PubMed  Google Scholar 

  39. Clay MR, Martinez AP, Weiss SW, Edgar MA. MDM2 Amplification in Problematic Lipomatous Tumors: analysis of FISH testing criteria. Am J Surg Pathol. 2015;39(10):1433–9. https://doi.org/10.1097/PAS.0000000000000468.

    Article  PubMed  Google Scholar 

  40. Neuhaus SJ, Barry P, Clark MA, Hayes AJ, Fisher C, Thomas JM. Surgical management of primary and recurrent retroperitoneal liposarcoma. Br J Surg. 2005;92(2):246–52. https://doi.org/10.1002/bjs.4802.

    Article  CAS  PubMed  Google Scholar 

  41. Elgar F, Goldblum JR. Well-differentiated liposarcoma of the retroperitoneum: a clinicopathologic analysis of 20 cases, with particular attention to the extent of low-grade dedifferentiation. Mod Pathol. 1997;10(2):113–20.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, Ontario, M5G 2C4, Canada

    Aoife J. McCarthy, Rajkumar Vajpeyi & Runjan Chetty

  2. University of Toronto, Toronto, Canada

    Aoife J. McCarthy, Paul Carroll, Rajkumar Vajpeyi, Gail Darling & Runjan Chetty

  3. Surgery and Critical Care Program, Departments of Thoracic Surgery and Surgical Oncology, University Health Network and University of Toronto, Toronto, Canada

    Paul Carroll & Gail Darling

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McCarthy, A.J., Carroll, P., Vajpeyi, R. et al. Well-Differentiated Liposarcoma (Atypical Lipomatous Tumor) Presenting as an Esophageal Polyp. J Gastrointest Canc 50, 589–595 (2019). https://doi.org/10.1007/s12029-018-0052-0

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