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Evaluation of the Effectiveness of Sugammadex for Digoxin Intoxication: An Experimental Study

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Abstract

Previous studies have shown that cyclodextrin group medicines bind to various drugs. The hypothesis of our study is to determine whether sugammadex could bind to digoxin and delay the cardiovascular toxicity of that drug. Twenty-eight sedated Wistar rats were infused with digoxin at 3 mg/h (0.25 mg/ml). Five minutes after the start of infusion, animals were treated with a bolus of either 16 mg/kg (Sgdx16), 100 mg/kg (Sgdx100), or 1000 mg/kg (Sgdx1000) sugammadex. The control group infusion did not contain sugammadex. Heart rate, electrocardiography, and respiratory rate were monitored. The primary endpoint was time to asystole. Digoxin infusion continued until the animals arrested. The time to asystole for the Sgdx1000 group was significantly longer compared to that for the control group (p < 0.05). The mean lethal dose of digoxin was 5.35 ± 2.06 mg/kg in the saline-treated rats. On the other hand, the mean lethal dose of digoxin was 8.54 ± 1.51 mg/kg in the sugammadex 1000 group (p < 0.05). The mean lethal dose of digoxin was significantly higher than control group (p < 0.05). We found that the 1000 mg/kg dose of sugammadex delayed digoxin cardiotoxicity in a rat model of digoxin toxicity. We conclude that further research must be conducted on the interaction between digoxin and sugammadex.

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Authors and Affiliations

  1. Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylül University, İzmir, Turkey

    Sule Ozbilgin, Beyza Küçükoztaş, Bülent Serhan Yurtlu, Volkan Hancı & Ali Günerli

  2. Department of Anesthesiology and Reanimation, School of Medicine, Katip Celebi University, İzmir, Turkey

    Derya Aslan Yurtlu

  3. Department of Experimental Laboratory Animal Science, School of Medicine, Dokuz Eylül University, İzmir, Turkey

    Gonca Kamacı & M. Ensari Güneli

  4. Department of Biology, School of Medicine, Dokuz Eylül University, İzmir, Turkey

    Sezen Korkut

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  1. Sule Ozbilgin
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  2. Derya Aslan Yurtlu
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Correspondence to Bülent Serhan Yurtlu.

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Ozbilgin, S., Yurtlu, D.A., Küçükoztaş, B. et al. Evaluation of the Effectiveness of Sugammadex for Digoxin Intoxication: An Experimental Study. Cardiovasc Toxicol 18, 400–406 (2018). https://doi.org/10.1007/s12012-018-9450-6

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  • DOI: https://doi.org/10.1007/s12012-018-9450-6

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