Abstract
We investigated the effects of supplemental chromium (Cr) as Cr (III) picolinate on pigs fed high-fat diets (HFD) in a 56-day experiment. Thirty-two crossbred pigs (9.6 kg) were allotted to four treatments with four blocks and two pigs/pen. Treatments included: (1) low-fat diet (fat < 3.5%; LFD) with no Cr, (2) HFD (fat > 30%) with no Cr, (3) HFD with 1,000 ppb Cr, and (4) HFD with 2,000 ppb Cr. Pigs fed HFD gained weight faster, consumed less, and had lower feed:gain (p < 0.05). Pigs fed HFD had higher respiration rates than pigs fed LFD on d 41 (p < 0.05). Plasma insulin on d 14 linearly decreased with Cr (p = 0.05). Plasma cholesterol concentrations were higher in the pigs fed HFD than those fed LFD, but were largely unaffected by supplemental Cr. Consumption of HFD resulted in greater carcass weight, perirenal fat, and backfat measures (p < 0.01) compared with the LFD group. Cr resulted in linear reductions of hot carcass weight (p = 0.08) and average backfat (p < 0.05). The effects of Cr on carcass fat measures were more pronounced in castrated males than in females. These results indicate that Cr attenuates some effects of a HFD, mainly body fat accretion of pigs, and especially in castrated pigs.
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References
Schwarz K, Mertz W (1959) Chromium(III) and the glucose tolerance factor. Arch Biochem Biophys 85:292–295
Mertz W, Toepfer EW, Roginski EE, Polansky MM (1974) Present knowledge of the role of chromium. Fed Proc 33:2275–2280
Vincent JB (2000) The biochemistry of chromium. J Nutr 130:715–718
Cefalu WT, Wang ZQ, Zhang XH, Baldor LC, Russell JC (2002) Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats. J Nutr 132:1107–1114
Bernao A, Meseguer I, Aguilar MV, Para MC, Munoz MJ (2004) Effect of different doses of chromium picolinate on protein metabolism in infant rats. J Trace Elem Med Biol 18:33–39
Offenbacher EG, Pi-Sunyer FX (1988) Chromium in human nutrition. Annu Rev Nutr 8:543–563
Chang X, Mowat DN (1992) Supplemental chromium for stressed and growing feeder calves. J Anim Sci 70:559–565
Anderson RA (1994) Stress effects on chromium nutrition of humans and farm animals. In: Lyons TP, Jacques KA (eds) Biotechnology in the feed industry - Proc Alltech’s Tenth Annual Symposium. Nottingham University Press, Loughborough, pp 267–274
Sahin K, Ozbey O, Onderci M, Cikim G, Aysondu MH (2002) Chromium supplementation can alleviate negative effects of heat stress on egg production, egg quality and some serum metabolites of laying Japanese quail. J Nutr 132:1265–1268
Kim BG, Lindemann MD, Cromwell GL (2009) The effects of dietary chromium(III) picolinate on growth performance, blood measurements, and respiratory rate in pigs kept in high and low ambient temperature. J Anim Sci 87:1695–1704
Lee DN, Weng CF, Yen HT, Shen TF, Chen BJ (2000) Effects of chromium supplementation and lipopolysaccharide injection on physiological responses of weanling pigs. Asian-Australas J Anim Sci 13:528–534
Striffler JS, Polansky MM, Anderson RA (1998) Dietary chromium decreases insulin resistance in rats fed a high-fat, mineral-imbalanced diet. Metabolism 47:396–400
Bhattacharya A, Rahman MM, McCarter R, O’Shea M, Fernandes G (2006) Conjugated linoleic acid and chromium lower body weight and visceral fat mass in high-fat-diet-fed mice. Lipids 41:437–444
Lissner L, Heitmann BL (1995) Dietary fat and obesity: evidence from epidemiology. Eur J Clin Nutr 49:79–90
Shepard TY, Weil KM, Sharp TA, Grunwald GK, Bell ML, Hill JO, Eckel RH (2001) Occasional physical inactivity combined with a high-fat diet may be important in the development and maintenance of obesity in human subjects. Am J Clin Nutr 73:703–708
Masek J, Fabry P (1959) High-fat diet and the development of obesity in albino rats. Experientia 15:444–445
Lemonnier D, Suquet JP, Aubert R, Degasquet P, Pequignot E (1975) Metabolism of mouse made obese by a high-fat diet. Diabetes & Metabolism 1:77–85
Han LK, Xu BJ, Kimura Y, Zheng Y, Okuda H (2000) Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity. J Nutr 130:2760–2764
Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA (2005) Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci USA 102:6207–6212
Kishino E, Ito T, Fujita K, Kiuchi Y (2006) A mixture of the Salacia reticulata (Kotala himbutu) aqueous extract and cyclodextrin reduces the accumulation of visceral fat mass in mice and rats with high-fat diet-induced obesity. J Nutr 136:433–439
Lavau M, Fried SK, Susini C, Freychet P (1979) Mechanism of insulin resistance in adipocytes of rats fed a high-fat diet. J Lipid Res 20:8–16
Davis P, Valacchi G, Pagnin E, Shao Q, Gross HB, Calo L, Yokoyama W (2006) Walnuts reduce aortic ET-1 mRNA levels in hamsters fed a high-fat, atherogenic diet. J Nutr 136:428–432
Miller ER, Ullrey DE (1987) The pig as a model for human nutrition. Annu Rev Nutr 7:361–382
Nafikov RA, Beitz DC (2007) Carbohydrate and lipid metabolism in farm animals. J Nutr 137:702–705
Page TG, Southern LL, Ward TL, Thompson DL Jr (1993) Effect of chromium picolinate on growth and serum and carcass traits of growing-finishing pigs. J Anim Sci 71:656–662
Lindemann MD, Wood CM, Harper AF, Kornegay ET, Anderson RA (1995) Dietary chromium picolinate additions improve gain:feed and carcass characteristics in growing-finishing pigs and increase litter size in reproducing sows. J Anim Sci 73:457–465
Mooney KW, Cromwell GL (1995) Effects of dietary chromium picolinate supplementation on growth, carcass characteristics, and accretion rates of carcass tissues in growing-finishing swine. J Anim Sci 73:3351–3357
Lien TF, Wu CP, Wang BJ, Shiao MS, Shiao TY, Lin BH, Lu JJ, Hu CY (2001) Effect of supplemental levels of chromium picolinate on the growth performance, serum traits, carcass characteristics and lipid metabolism of growing-finishing pigs. Anim Sci 72:289–296
Evock-Clover CM, Polansky MM, Anderson RA, Steele NC (1993) Dietary chromium supplementation with or without somatotropin treatment alters serum hormones and metabolites in growing pigs without affecting growth performance. J Nutr 123:1504–1512
Mooney KW, Cromwell GL (1999) Efficacy of chromium picolinate on performance and tissue accretion in pigs with different lean gain potential. J Anim Sci 77:1188–1198
Matthews JO, Southern LL, Fernandez JM, Pontif JE, Bidner TD, Odgaard RL (2001) Effect of chromium picolinate and chromium propionate on glucose and insulin kinetics of growing barrows and on growth and carcass traits of growing-finishing barrows. J Anim Sci 79:2172–2178
Lindemann MD, Purser KW (1997) Evaluation of dietary chromium picolinate supplementation for growing-finishing pigs in a commercial setting. J Anim Sci 75(Suppl. 1):67
Kim BG, Lindemann MD (2007) A new spreadsheet method for the experimental animal allotment. J Anim Sci 85(Suppl. 2):112
National Research Council (1998) Nutrient requirements of swine, 10th edn. National Academy Press, Washington, DC
National Pork Producers Council (2000) Pork composition and quality assessment procedures. National Pork Producers Council, Des Moines, IA
Association of Official Analytical Chemists (1995) Official methods of analysis, 15th edn. AOAC, Washington, DC
Littell RC, Henry PR, Ammerman CB (1998) Statistical analysis of repeated measures data using SAS procedures. J Anim Sci 76:1216–1231
Anderson RA, Cheng N, Bryden NA, Polansky MM, Chi J, Feng J (1997) Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes 46:1786–1791
Martin J, Wang ZQ, Zhang XH, Wachtel D, Volaufova J, Matthews DE, Cefalu WT (2006) Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 29:1826–1832
Azain MJ, Seerley RW, Reagan JO, Anderson MK (1991) Effect of a high-fat diet on the performance response to porcine somatotropin (PST) in finishing pigs. J Anim Sci 69:153–161
Azain MJ (2001) Fat in swine nutrition. In: Lewis AJ, Southern LL (eds) Swine nutrition, 2nd edn. CRC, Boca Raton, pp 95–105
Boleman SL, Boleman SJ, Bidner TD, Southern LL, Ward TL, Pontif JE, Pike MM (1995) Effect of chromium picolinate on growth, body composition, and tissue accretion in pigs. J Anim Sci 73:2033–2042
Lindemann MD (1999) Chromium and swine nutrition. J Trace Elem Exp Med 12:149–161
Schoenherr WD, Stahly TS, Cromwell GL (1989) The effects of dietary fat or fiber addition on yield and composition of milk from sows housed in a warm or hot environment. J Anim Sci 67:482–495
Renaudeau D, Quiniou N, Noblet J (2001) Effects of exposure to high ambient temperature and dietary protein level on performance of multiparous lactating sows. J Anim Sci 79:1240–1249
Brindley DN, Cooling J, Glenny HP, Burditt SL, McKechnie IS (1981) Effects of chronic modification of dietary fat and carbohydrate on the insulin, corticosterone and metabolic responses of rats fed acutely with glucose, fructose or ethanol. Biochem J 200:275–283
Tannenbaum BM, Brindley DN, Tannenbaum GS, Dallman MF, McArthur MD, Meaney MJ (1997) High-fat feeding alters both basal and stress-induced hypothalamic–pituitary–adrenal activity in the rat. Am J Physiol 273:E1168–E1177
Reaven GM, Lerner RL, Stern MP, Farquhar JW (1967) Role of insulin in endogenous hypertriglyceridemia. J Clin Invest 46:1756–1767
Muurling M, Jong MC, Mensink RP, Hornstra G, Dahlmans VE, Pijl H, Voshol PJ, Havekes LM (2002) A low-fat diet has a higher potential than energy restriction to improve high-fat diet-induced insulin resistance in mice. Metabolism 51:695–701
Amato P, Morales AJ, Yen SS (2000) Effects of chromium picolinate supplementation on insulin sensitivity, serum lipids, and body composition in healthy, nonobese, older men and women. J Gerontol A Biol Sci Med Sci 55:M260–M263
Shelton JL, Payne RL, Johnston SL, Bidner TD, Southern LL, Odgaard RL, Page TG (2003) Effect of chromium propionate on growth, carcass traits, pork quality, and plasma metabolites in growing-finishing pigs. J Anim Sci 81:2515–2524
van de Ligt CP, Lindemann MD, Cromwell GL (2002) Assessment of chromium tripicolinate supplementation and dietary energy level and source on growth, carcass, and blood criteria in growing pigs. J Anim Sci 80:483–493
van de Ligt CP, Lindemann MD, Cromwell GL (2002) Assessment of chromium tripicolinate supplementation and dietary protein level on growth, carcass, and blood criteria in growing pigs. J Anim Sci 80:2412–2419
Rink C, Roy S, Khanna S, Rink T, Bagchi D, Sen CK (2006) Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Leprdb obese diabetic mice with niacin-bound chromium. Physiol Genomics 27:370–379
Acknowledgements
Special appreciation is expressed to Merrick Animal Nutrition, Inc., Middleton, WI, for the donation of SOWEENA Dry Fat 4-80, a dried fat product, to Prince Agri Products, Inc., Quincy, IL, for providing Chromax, to Nutrition 21, Purchase, NY, for partial support for the plasma lipid analysis, and to Akey Inc., Lewisburg, Ohio, for ingredients used in the experiments. Appreciation is also expressed to David Higginbotham, Anthony Quant, Yulin Ma, Susan Hayes, and Alma Dani True for assistance with diet preparation, data and sample collection, and laboratory assays.
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Kim, B.G., Lindemann, M.D. & Cromwell, G.L. Effects of Dietary Chromium (III) Picolinate on Growth Performance, Respiratory Rate, Plasma Variables, and Carcass Traits of Pigs Fed High-Fat Diets. Biol Trace Elem Res 133, 181–196 (2010). https://doi.org/10.1007/s12011-009-8417-7
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DOI: https://doi.org/10.1007/s12011-009-8417-7