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Garlic (Allium sativum L.) as a Potential Antidote for Cadmium and Lead Intoxication: Cadmium and Lead Distribution and Analysis in Different Mice Organs

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Abstract

Analysis and distribution of Pb and Cd in different mice organs including liver, kidney, spleen, heart and blood were evaluated after treatment with different aqueous concentrations of garlic (12.5–100 mg/l). Atomic absorption spectrometry (AAS) was used for analysis of Pb and Cd in these organs. Treatment of Cd–Pb exposed mice with garlic (12.5–100 mg/l) reduced Pb concentrations by 44.65, 42.61, 38.4, 47.56, and 66.62% in liver, kidney, heart, spleen and blood respectively. Moreover, garlic reduced Cd levels by 72.5, 87.7, 92.6, 95.6, and 71.7% in liver, kidney, heart, spleen and blood respectively. The suppressed immune responses in mice pretreated with Cd–Pb mixture were reversed by 48.85, 55.82, 81.4 and 90.7 in the presence of 100, 50, 25, and 12.5 mg/ml of garlic extract.

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Acknowledgment

We thank the Faculty of Scientific Research at Jordan University of Science and Technology for financial support. Thanks to Mr. M. Damrah (Animal House, Faculty of Medicine, JUST). Many thanks to Asma Ayoub for her technical assistance in preparation of the samples. Furthermore, we acknowledge Yarmouk University Department of Chemistry for analysis the samples by AAS.

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Authors and Affiliations

  1. Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P. O. Box 3030, Irbid, 22110, Jordan

    A. M. Massadeh & A. S. AlKofahi

  2. Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan

    S. A. Al-Safi

  3. Department of Chemistry, Faculty of Science, Yarmouk University, Irbid, Jordan

    I. F. Momani & A. A. Alomary

  4. Department of Chemistry, Mutah University, Al-Karak, Jordan

    Q. M. Jaradat

Authors
  1. A. M. Massadeh
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  2. S. A. Al-Safi
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  3. I. F. Momani
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  4. A. A. Alomary
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  5. Q. M. Jaradat
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  6. A. S. AlKofahi
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Correspondence to A. M. Massadeh.

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Massadeh, A.M., Al-Safi, S.A., Momani, I.F. et al. Garlic (Allium sativum L.) as a Potential Antidote for Cadmium and Lead Intoxication: Cadmium and Lead Distribution and Analysis in Different Mice Organs . Biol Trace Elem Res 120, 227–234 (2007). https://doi.org/10.1007/s12011-007-8017-3

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  • DOI: https://doi.org/10.1007/s12011-007-8017-3

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