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Treatment Considerations in the Radiologically Isolated Syndrome

  • Multiple Sclerosis and Related Disorders (J Graves, Section Editor)
  • Published:
Current Treatment Options in Neurology Aims and scope Submit manuscript

Abstract

Purpose of review

This review provides the reader with updated information needed to make an accurate diagnosis of radiologically isolated syndrome (RIS), discusses controversies and considerations related to therapeutic intervention in RIS, and summarizes ongoing clinical intervention trials.

Recent findings

Individuals with RIS lack clinical neurological symptoms but are at risk for the subsequent development of a first clinical neurological event consistent with a diagnosis of multiple sclerosis. There are two ongoing clinical intervention trials to determine whether disease-modifying treatments for multiple sclerosis can delay or prevent a first clinical event in individuals with RIS.

Summary

If clinical trials demonstrate a beneficial effect of disease-modifying therapy, such interventions should be considered in individuals with RIS.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. New Haven, CT, USA

    Naila Makhani MD, MPH

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  1. Naila Makhani MD, MPH
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Conflict of Interest

Dr. Makhani is supported, in part, by grant number K23NS101099 from the National Institute of Neurological Diseases and Stroke at the National Institutes of Health.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Multiple Sclerosis and Related Disorders

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Makhani, N. Treatment Considerations in the Radiologically Isolated Syndrome. Curr Treat Options Neurol 22, 3 (2020). https://doi.org/10.1007/s11940-020-0608-8

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  • DOI: https://doi.org/10.1007/s11940-020-0608-8

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