Conclusions
The pathophysiology of essential hypertension is not homogeneous; it is thought to consist of multifactorial disorders. Therefore, an appropriate first-line antihypertensive drug should be selected according to the pathophysiologic state of this disease in each patient. In this article, preferable first-line antihypertensive drugs were discussed from a clinical, general practice viewpoint on the basis of the pathophysiologic characteristics of patients with benign essential hypertension. The usefulness of some low-dose combination therapies was also discussed from the same viewpoint.
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Iimura, O. Recommendations for first-line antihypertensive drugs and combination therapies. Current Science Inc 2, 421–422 (2000). https://doi.org/10.1007/s11906-000-0019-x
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DOI: https://doi.org/10.1007/s11906-000-0019-x