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Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway

  • Published:
Current Colorectal Cancer Reports

Abstract

It was previously though that adenomas gave rise to colorectal cancers and that other polyps were harmless. Serrated polyps—hyperplastic polyps, serrated adenomas, and sessile serrated adenomas—show distinct patterns of genetic and epigentic mutation that suggest their role in an alternative pathway of colorectal cancer development. In parallel with these findings are improved demographic and histologic data that also indicate that a subset of serrated polyps are precursors of cancer.

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Authors and Affiliations

  1. Histopathology Unit, Cancer Research UK, 44, Lincoln’s Inn Fields, London, WC2A 3PX, UK

    Alan R. Watson MA, MD, MRCP

Authors
  1. Alan R. Watson MA, MD, MRCP
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  2. Janusz Jankowski MD, PhD, FRCP
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Correspondence to Alan R. Watson MA, MD, MRCP.

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Watson, A.R., Jankowski, J. Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway. Curr colorectal cancer rep 3, 3–9 (2007). https://doi.org/10.1007/s11888-007-0009-3

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  • DOI: https://doi.org/10.1007/s11888-007-0009-3

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