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Pediatric Drug Hypersensitivity

  • Anaphylaxis and Drug Allergy (David A. Khan & Mariana Castells, Section Editors)
  • Published:
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Abstract

Purpose of Review

Pediatric drug hypersensitivity is a rapidly evolving field. The purpose of this paper is to review the current state of pediatric drug hypersensitivity and highlight new developments in diagnosis and management.

Recent Findings

This paper will discuss the safety and use of risk stratification to proceed directly to oral challenge without prior skin testing for β-lactam reactions. We review unique aspects of pediatric drug challenges and desensitizations.

Summary

It is important to accurately diagnose pediatric drug hypersensitivity reactions through a detailed history, physical examination, and available diagnostic testing. Understanding of the underlying mechanism leads to appropriate classification which is necessary to direct management. The decision to perform drug challenge, desensitization, or recommend avoidance of a medication can have a significant impact on a patient’s treatment. Utilization of weight-based dose and infusion rate adjustments for current drug challenge and desensitization protocols optimize success.

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Authors and Affiliations

  1. Division of Allergy, Pulmonary and Critical Care, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

    Christine R. F. Rukasin

  2. Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN, 37232, USA

    Allison E. Norton

  3. Division of Allergy and Immunology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA

    Ana Dioun Broyles

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  1. Christine R. F. Rukasin
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Rukasin, C.R.F., Norton, A.E. & Broyles, A.D. Pediatric Drug Hypersensitivity. Curr Allergy Asthma Rep 19, 11 (2019). https://doi.org/10.1007/s11882-019-0841-y

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