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Profiling of skin anti-aging related proteins in human dermal fibroblasts by decursin in Angelica gigas Nakai

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Abstract

The extract of Angelica gigas Nakai by supercritical CO2 increased the expression of collagen synthesis-related proteins in human dermal fibroblast, including type 1(α-2) collagen chain precursor (pI 9.08, MW 129.7), procollagen C-endopeptidase (pI 7.40, MW 47.97), and prolyl 4-hydroxylase (pI 5.49, MW 60.90). It also increased the expression level of interaction-related proteins, α-actinin (pI 5.47, MW 105.5), integrin-β1 (pI 5.27, MW 88.46). The expression levels of these proteins by pure decursin were similar to those by supercritical fluid extract. By the dose concentration experiment, decursin in A. gigas was found to play the major role in expression level increases. Proteome analysis proved that decursin in A. gigas promoted synthesis of proteins related to skin anti-aging in human dermal fibroblasts.

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Authors and Affiliations

  1. Head of Cosmetic Science Major, Applied Biotechnology Program, Graduate School, Ajou University, Wonchon-dong, Youngtong-gu, Suwon, Gyunggi-do, 442-749, Korea

    Mi Ae Yoo, Young Keun Song, Hyein Jang, Dong Myung Kim & Sang Yo Byun

  2. Univera, Sungsu-dong, Sungdong-gu, Seoul, 133-120, Korea

    Hyein Jang

  3. Kolmar Korea, Chonui Myun, Yunki Gun, Chunganm-do, 339-851, Korea

    Dong Myung Kim

Authors
  1. Mi Ae Yoo
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  2. Young Keun Song
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  3. Hyein Jang
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  4. Dong Myung Kim
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  5. Sang Yo Byun
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Correspondence to Sang Yo Byun.

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Yoo, M.A., Song, Y.K., Jang, H. et al. Profiling of skin anti-aging related proteins in human dermal fibroblasts by decursin in Angelica gigas Nakai. Korean J. Chem. Eng. 28, 880–885 (2011). https://doi.org/10.1007/s11814-010-0430-1

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  • DOI: https://doi.org/10.1007/s11814-010-0430-1

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