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Invasive mucinous adenocarcinoma with lepidic-predominant pattern coexisted with tuberculosis: a case report

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Abstract

We observed a rare case of invasive mucinous adenocarcinoma (IMA) with a lepidic-predominant pattern accompanied by pulmonary tuberculosis. An 85-year-old man with repeated cough and sputum was admitted to Xinhua Hospital. T-SPOT test result was 212 pg/ml (reference value of negative is < 14 pg/ml), Mycobacterium tuberculosis culture was positive, and tuberculin skin test (PPD) was negative (skin induration < 5 mm). The patient was treated with several courses of antibiotics and anti-tuberculosis treatments. Repeated chest CT scans showed disease progression. Bronchoscopy yielded negative results. PET-CT scans showed negative results. A percutaneous lung biopsy revealed mucin-secreting cells lining the alveolar walls. IMA with a lepidic-predominant pattern was diagnosed after invasiveness was found after experimental treatments. Simultaneous occurrence of pulmonary tuberculosis and lung cancer are common; however, the present case of IMA having a lepidic-predominant pattern and coexisting with active tuberculosis has not been reported yet.

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Acknowledgements

The support from National Natural Science Foundation of China (No. 81200017) is gratefully acknowledged.

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China

    Xinxin Xu, Ling Yang & Jianqiang Kang

  2. Allergy Department, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200001, China

    Yinshi Guo

  3. Department of Interventional Radiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China

    Qiuying Li

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  1. Xinxin Xu
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  2. Yinshi Guo
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  3. Qiuying Li
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  4. Ling Yang
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  5. Jianqiang Kang
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Corresponding author

Correspondence to Ling Yang.

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Xu, X., Guo, Y., Li, Q. et al. Invasive mucinous adenocarcinoma with lepidic-predominant pattern coexisted with tuberculosis: a case report. Front. Med. 12, 330–333 (2018). https://doi.org/10.1007/s11684-017-0545-4

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  • DOI: https://doi.org/10.1007/s11684-017-0545-4

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