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Dalitong Granule (达立通颗粒) combined with electroacupuncture in the treatment of functional dyspepsia: A randomized controlled trial

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Abstract

Objective

To explore clinical short and long-term effect of combining Dalitong Granule (达立通颗粒, DG) and electroacupuncture group (EA) in the treatment of functional dyspepsia.

Methods

Totally 640 patients with confirmed functional dyspepsia were randomly divided into 4 groups using a randomized digital table: the DG group, the EA group, the combined group and the control group, 160 cases in each group. The DG group was treated with 6 g DG 3 times daily; the EA group was treated with puncture of points Zusanli (ST36), Zhongwan (CV12), Neiguan (PC6), Taichong (LR3) and Gongsun (SP4) twice daily; the combined group with above-mentioned DG and EA; and the control group with 5 mg mosapride 3 times, 20 mg pantoprazole and 25 mg amitriptylines twice daily. The treatment course was 4 weeks for all groups. The symptom score, quality of life score by Short Form 36 Health Survey Questionnaires (SF-36), plasma motilin by radioimmunoassay, electrogastrographic frequencies by electrogastrogram (EGG) and gastric emptying by B-sonography were examined, and adverse reactions were observed before, at the end of treatment and 60 weeks post-treatment.

Results

In the DG group 1 case dropped out for not taking medicine strictly and 1 case was lost to follow-up, while 1 case in the EA group and 2 cases in the combined therapy group were lost to follow-up. Compared with pre-treatment, quality of life score, plasma motilin, electrogastrographic frequencies and gastric emptying were all increased significantly, while symptom score was decreased significantly at the end of treatment in each group (P<0.01); in the combined group quality of life score, plasma motilin, electrogastrographic frequencies and gastric emptying were all significantly higher than those in the other groups, while symptom score was significantly lower than in the other groups (P<0.05). Compared with at the end of treatment, these indices changed insignificantly in the combined group and the EA group 60 weeks post-treatment (P>0.05), but the 4 increased indices were all decreased significantly, and symptom score was increased significantly in the DG and the control groups (P>0.05). The short and long-term total effective rates in the combined group were all significantly higher than those in the other treatment groups (P<0.05 or P<0.01). No serious adverse reaction occurred in the four groups.

Conclusion

Combined treatment of DG and EA could increase both plasma motilin and electrogastrographic frequencies, promote gastric emptying, alleviate the symptom of dyspepsia so as to increase quality of life, with better safety and long-term effect.

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References

  1. Tan VP, Cheung TK, Wong WM, Pang R, Wong BC. Treatment of functional dyspepsia with sertraline: a doubleblind randomized placebo-controlled pilot study. World J Gastroenterol 2012;18:6127–6133.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Chang FY, Chen PH, Wu TC, Pan WH, Chang HY, Wu SJ, et al. Prevalence of functional gastrointestinal disorders in Taiwan: questionnaire-based survey for adults based on the Rome criteria. Asia Pac J Clin Nutr 2012;21:594–600.

    PubMed  Google Scholar 

  3. Aro P, Talley NJ, Agréus L, Johansson SE, Bolling-Sternevald E, Storskrubb T, et al. Functional dyspepsia impairs quality of life in the adult population. Aliment Pharmacol Ther 2011;33:1215–1224.

    Article  CAS  PubMed  Google Scholar 

  4. Park JM, Choi MG, Cho YK, Lee IS, Kim JI, Kim SW, et al. Functional gastrointestinal disorders diagnosed by Rome questionnaire in Korea. J Neurogastroenterol Motil 2011;17:279–286.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Hu J, Gruber KJ, Hsueh KH. Psychometric properties of the Chinese version of the SF-36 in older adults with diabetes in Beijing, China. Diabetes Res Clin Pract 2010;88:273–281.

    Article  PubMed  Google Scholar 

  6. Yin J, Chen JD. Electrogastrography: methodology, validation and applications. J Neurogastroenterol Motil 2013;19:5–17.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Gilja OH, Lunding J, Hausken T, Gregersen H. Gastric accommodation assessed by ultrasonography. World J Gastroenterol 2006;12:2825–2829.

    PubMed Central  PubMed  Google Scholar 

  8. Tack J, Masaoka T, Janssen P. Functional dyspepsia. Curr Opin Gastroenterol 2011;27:549–557.

    Article  CAS  PubMed  Google Scholar 

  9. Haruma K, Imamura H, Kusunoki H, Manabe N, Hata J. Diagnosis and pathogenesis in functional dyspepsia. Japan J Clin Med 2008;66:1379–1384.

    Google Scholar 

  10. Daisuke K, Noriaki M, Jiro H, Ken H, Shinji T, Kazuaki C. Long-term ultrasonographic follow-up study of gastric motility in patients with functional dyspepsia. J Clin Biochem Nutr 2008;42:144–149.

    Article  Google Scholar 

  11. Suzuki H, Okada S, Hibi T. Proton-pump inhibitors for the treatment of functional dyspepsia. Therap Adv Gastroenterol 2011;4:219–226.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Franks I. Dyspepsia: psychological factors in functional dyspepsia—keeping an open mind. Nat Rev Gastroenterol Hepatol 2012;9:488.

    Article  PubMed  Google Scholar 

  13. Xu S, Hou X, Zha H, Gao Z, Zhang Y, Chen JD. Electroacupuncture accelerates solid gastric emptying and improves dyspeptic symptoms in patients with functional dyspepsia. Dig Dis Sci 2006;51:2154–2159.

    Article  PubMed  Google Scholar 

  14. Li J, Shi XF, Zhou LY, Xue DB. Experimental study on electroacupuncture for strengthening gastrointestinal motility in the rat with acute pancreatitis. Chin Acupunct Moxibust (Chin) 2008;28:365–368.

    Google Scholar 

  15. Han YJ, Dai WW, Peng L, Zhou L, Ma HF. Effect of acupuncture on contents of beta-endorphin in the plasma and hypothalamus in rats with stress-induced gastric mucosal injury. Acupunct Res (Chin) 2011;36:341–346.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterology, the First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, 453100, China

    Chao-xian Zhang  (张超贤)

  2. Department of Stomatology, the First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, 453100, China

    Li-ke Guo  (郭李柯)

Authors
  1. Chao-xian Zhang  (张超贤)
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  2. Li-ke Guo  (郭李柯)
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Correspondence to Chao-xian Zhang  (张超贤).

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Zhang, Cx., Guo, Lk. Dalitong Granule (达立通颗粒) combined with electroacupuncture in the treatment of functional dyspepsia: A randomized controlled trial. Chin. J. Integr. Med. 21, 743–750 (2015). https://doi.org/10.1007/s11655-015-2175-5

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  • DOI: https://doi.org/10.1007/s11655-015-2175-5

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