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Differential diagnosis between fibroadenoma, giant fibroadenoma and phyllodes tumour: sonographic features and core needle biopsy

Diagnosi differenziale tra fibroadenoma, fibroadenoma gigante e tumore filloide: caratteristiche ultrasonografiche e core needle biopsy

  • Breast Radiology / Senologia
  • Published:
La radiologia medica Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to analyse mammographic and ultrasound (US) features of fibroadenoma and phyllodes tumour and assess the diagnostic accuracy of mammography, US and US-guided core needle biopsy (CNB) in the differential diagnosis of these two lesions.

Materials and methods

The results of the pathological analysis of excision biopsy of 83 lesions (67 fibroadenomas and 16 phyllodes tumours) were correlated with the findings of mammography, US and US-guided CNB performed on 83 women with a mean age of 45.4 years (range 18–75 years).

Results

Sensitivity, specificity and positive predictive values compared with histology were 45%, 50% and 79% for mammography, 34%, 69% and 82% for US and 81%, 97% and 87% for US-guided CNB (p=0.001).

Conclusions

The almost complete overlap between mammographic and US parameters of fibroadenomas and phyllodes tumours and the absence of pathognomonic features preclude the differential diagnosis between the two histological types. US-guided CNB is a valuable tool in the differential diagnosis between fibroadenoma and phyllodes tumour.

Riassunto

Obiettivo

Scopo del nostro lavoro è stato analizzare le caratteristiche mammografiche e ultrasonografiche di fibroadenoma e tumore filloide e calcolare láccuratezza diagnostica della mammografia, dellécografia e della core needle biosy (CNB) ecoguidata nella diagnosi differenziale tra fibroadenoma e tumore filloide.

Materiali e metodi

I risultati anatomopatologici della biopsia escissionale (BE) di 83 lesioni (67 fibroadenomi e 16 tumori filloidi) sono stati confrontati con i risultati dellésame mammografico, ecografico e della CNB ecoguidata, eseguita in 83 donne di età media di 45,4 anni (range 18–75 anni).

Risultati

I valori di sensibilità, specificità, valore predittivo positivo erano del 45%, 50%, 79% per la mammografia, del 34%, 69%, 82% per lécografia e dell’81%, 97% e 87% per la CNB ecoguidata, confrontate con lístologia definitiva (p=0,001).

Conclusioni

La sostanziale sovrapposizione tra i parametri mammografici e ultrasonografici dei fibroadenomi e dei tumori filloidi e lássenza di caratteristiche patognomoniche non consentono di fare diagnosi differenziale tra i due istotipi. La CNB ecoguidata rappresenta un valido strumento nella diagnosi differenziale tra fibroadenoma e tumore filloide.

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Authors and Affiliations

  1. Dipartimento di Internistica Clinica e Sperimentale “Magrassi-Lanzara”, Sezione di Radiodiagnostica e Radioterapia, Seconda Università degli Studi di Napoli, P.zza Miraglia 2, 80138, Napoli, Italy

    G. Gatta, F. Iaselli, V. Parlato, G. Di Grezia, R. Grassi & A. Rotondo

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  1. G. Gatta
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  2. F. Iaselli
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  3. V. Parlato
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  4. G. Di Grezia
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  5. R. Grassi
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  6. A. Rotondo
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Correspondence to G. Gatta.

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Gatta, G., Iaselli, F., Parlato, V. et al. Differential diagnosis between fibroadenoma, giant fibroadenoma and phyllodes tumour: sonographic features and core needle biopsy. Radiol med 116, 905–918 (2011). https://doi.org/10.1007/s11547-011-0672-y

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  • DOI: https://doi.org/10.1007/s11547-011-0672-y

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